SLIDE 1
Medicine Mathematics Physics Chemistry Biology
Computer Science
Health and computer science
Systems biology Computational chemistry Computational biology Bioinformatics Health informatics
Computational Health at UNIPI Corrado Priami - - PowerPoint PPT Presentation
Computational Health at UNIPI Corrado Priami - - PowerPoint PPT Presentation
Computational Health at UNIPI Corrado Priami corrado.priami@unipi.it Alina Srbu alina.sirbu@unipi.it Health and computer science Mathematics Health Systems informatics biology Medicine Computer Physics Science Bioinformatics
SLIDE 2
SLIDE 3
CS department UNIPI Stanford University Translational medicine
SLIDE 4
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
- Recently classified disease - children suddenly develop tics, obsessive
behaviour, fears, sleep and eating disorders
Psychological? Bacterial infection? Metabolomics Proteomics Clinical history
Mechanisms of the disease still unknown!
Biomarkers Mechanisms Better therapy
SLIDE 5
Machine learning for disease diagnosis
- Diagnosis - classification problem
PANS data
Machine learning
PANS diagnosis IBS data
Machine learning
IBS diagnosis
Challenge deadline 15th January
RAC RAC
SLIDE 6
Sleeping patterns and health
Activity Hormones: cortisol, melatonin, .. Food Sleep quality Stress, feelings HOW DO THEY ALL WORK TOGETHER? Wrist band data
SLIDE 7
Dynamic models for health
Time series data Pathways Domain knowledge simulations Drug testing Drug design Disease mechanisms Dynamic computational model
SLIDE 8
Corrado Priami corrado.priami@unipi.it Alina Sîrbu alina.sirbu@unipi.it
References 1. https://sparkglobal.io/ 2. http://www.sbvimprover.com/challenge-5 3. https://github.com/alsri/RAC 4. Lauria, M., Persico, M., Dordevic, N., Cominetti, O., Matone, A., Hosking, J., Jeffery, A., Pinkney, J., Da Silva, L., Priami, C. and Montoliu, I., 2018. Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73). Scientific reports, 8(1), p.1393. 5. Simoni, G., Reali, F., Priami, C. and Marchetti, L., 2019. Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 6. Sîrbu, Alina, Martin Crane, and Heather Ruskin. "Data integration for microarrays: Enhanced inference for gene regulatory networks." Microarrays 4, no. 2 (2015): 255-269.