Comprehensive Canada-Kyrgyz Biosecurity, Biocontainment & - - PowerPoint PPT Presentation

Comprehensive Canada-Kyrgyz Biosecurity, Biocontainment & Biosafety Cooperation

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The Global Partnership

Under Canada’s leadership, the G8 launched the Global Partnership Against the Spread of Weapons and Materials of Mass Destruction at the 2002 G8 Summit in Kananaskis

• Kananaskis Statement

We commit ourselves to prevent terrorists, or those that harbour them, from acquiring or developing nuclear, chemical, radiological and biological weapons; missiles; and related materials, equipment and technology.

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The Global Partnership

Kananaskis Summit (2002)

• G8 committed up to US $20 billion
• 23 partner countries today
• Canada committed $1 billion
• Principles: biosafety & biosecurity

Hokkaido Summit (July 2008)

• We also recognize that the GP must

evolve further to address new, emerging risks worldwide if we are to prevent terrorists or those that harbour them from acquiring chemical, biological, radiological, nuclear weapons and/or missiles.

• G8 REPORT ON THE GLOBAL PARTNERSHIP

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Comprehensive Biosecurity and Biosafety Program for the Kyrgyz Republic

• Canada and the Kyrgyz Republic are cooperating to implement a

comprehensive biological security/safety and non-proliferation program in the Kyrgyz Republic

• Objective is to reduce the threat of theft, sabotage and/or terrorist

acquisition of vulnerable pathogen collections

• Important human and animal health benefits
• Canada is prepared to provide up to $40 Million for:

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The Kyrgyz Republic

• Population ~ 5 million
• Size ~ 200,000 km2
• Terrain - 94% mountainous
• Agriculture >1/3 of GDP
• Ratified BTWC in 2004

Deadly diseases in Kyrgyzstan:

• Anthrax
• Plague
• Brucellosis
• FMD
• Rabies
• Avian Influenza

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Kyrgyz Bio Labs

Ministry of Health Ministry of Agriculture Academy of Sciences

• Expertise in working safely with dangerous endemic

diseases (e.g. anthrax, brucella, plague, CCHF, FMD, Sheep pox)

• No lab-acquired infections despite working with these

pathogens on open-bench (no biosafety cabinets, no secondary containment systems)

• Excellent microbiological technique to reduce aerosols at

source

• But there is room for improvement!

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Canada-Kyrgyz Treaty

AGREEMENT BETWEEN THE GOVERNMENT OF CANADA AND THE GOVERNMENT OF THE KYRGYZ REPUBLIC CONCERNING COOPERATION IN THE FIELD OF BIOLOGICAL SECURITY AND BIOLOGICAL SAFETY

• Provides necessary legal framework for implementation of cooperative projects.
• In the Preamble, both Parties affirm their “DESIRE to contribute to the

strengthening of the Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction done at London, Moscow and Washington on 10 April 1972.”

• Other Key provisions include:
• Peaceful Uses
• Taxation
• Indemnification
• To be signed in Bishkek August 2008
• Ratification in Fall 2008
• Administrative application to allow critical physical security upgrades at several facilities

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New Biosafety Level 3 Laboratory

Purpose

• Enhance biosecurity, biosafety

& biocontainment in Kyrgyz Republic

• Central Repository to

consolidate BSL3 Pathogens

• Reduce Threat of release of

dangerous pathogens

Mandate of New Lab

• serve as the central repository,

consolidating all dangerous pathogens and BSL3 activities in the Kyrgyz Republic.

• conduct human and animal

health diagnostics in a secure and safe manner Цель

• Увеличение биологической

безопасности, биологическая безопасность и Биологическое Сдерживание в Киргизской Республике

• Центральный Склад,

чтобы объединить Болезнетворные микроорганизмы BSL3 лаборатории

• Уменьшить Угрозу выпуска

опасных болезнетворных микроорганизмов

Мандат Новой Лаборатории

• Служить центральным складом,

объединяя все опасные болезнетворные микроорганизмы и действия BSL3 лаборатории в Киргизской Республике

• Проведите диагностику здоровья

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General Concept for New Laboratory

• Based on Canadian Science Centre for

Human and Animal Health. Winnipeg, Canada

• Expected construction cost = $30 million

Achieving a successful BSL3 facility in Kyrgyzstan where there are technical and resource limitations depends on careful advance planning during programming phase. Laboratory Programming Design Construction Commissioning & Certification

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Key Considerations

Security for the nation’s collection of dangerous pathogens

Perimeter Security Office & Support

BSL 2 BSL 3

Repository Building Entry

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Balance: safe and secure facility that can be successfully certified & facility that can be sustained in long term

Cost-effective to maintain and operate!

Key Considerations

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Floor 1 – Kyrgyz Laboratory

Shared support Animal Health Human Health Shared entry

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Suite Concept

• Separate virology and bacteriology suites

– Each suite has multiple lab units

Bacteriology Virology

A culture

• f Bacillus

anthracis Cell culture for growing virus

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Program Areas

The new Kyrgyz laboratory requires more BSL3 space to diagnose indigenous agents

BSL 2 Laboratories BSL 3 Laboratories ABSL 3 Holding / Procedure Building & Lab Support Security Admin & Lab Offices

759 SQ.M. 992 SQ.M. 980 SQ.M. 192 SQ.M. 530 SQ.M.

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Laboratory Project Schedule

Commissioning Construction Bid and Negotiate Construction Documents Design Development Schematic Design Program/Feasibility Year 4 Year 3 Year 2 Year 1 Phase Commissioning Construction Bid and Negotiate Construction Documents Design Development Schematic Design Program/Feasibility Year 4 Year 3 Year 2 Year 1 Phase

Completed Dec 2007 Begin July 2009 Begin July 2008

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A Joint Effort

• Canada and the Kyrgyz Republic have established a

very effective working relationship

• Canada-Kyrgyz Biological Laboratory Working Group
• Meets every 2 months in Bishkek
• Participation by all relevant Kyrgyz ministries and agencies
• Stakeholder input and buy-in at all phases of projects
• Support from Senior Leadership
• Shared commitment to identifying “Kyrgyz solutions”
• Twinning Program with Winnipeg Laboratory
• Coordination & Cooperation with Others
• World Bank
• France (INSERM Lab)

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Other Biosafety Cooperation

Training

• KSCQZD Training

Center, Almaty

• Annual Training Plans
• Courses & Conferences
• Resources

Guidelines

Development & modernization

• f guidelines,

standards and regs on biosafety & biosecurity in Kyrgyz Republic

Associations

• International Affiliations
• BACAC

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Scientific Cooperation

• Canadian funded Science Projects (ISTC):

– KR1122: Biotechnological Approaches to the Creation of New Botanical Pesticides and Molecular-Biological Aspects of Their Influence on Harmful Organisms – KR1327: The estimation of Potential Biological Danger from Natural Arbovirus Foci in the Kyrgyz Republic with the help of Modern Molecular-Genetic Methods – KR1325: Enhancement of FMD Control Program in Kyrgyzstan – KR1389: Monitoring Epizootic Conditions and Prevention of the Occurrence of Rabies in People and Animals – KR1429: Epidemiological Monitoring of Avian Flu Virus Circulation in the Nature, an Estimation of Biological Danger of the Pestholes in KR

• Total Canadian funding = $1.7 million

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Conclusion

• Canada-Kyrgyz cooperation to enhance

Biosafety & Biosecurity has many benefits:

– Increased security

• National, regional and international

– Public and animal health

• National and regional implications

– Scientific advancement and exchange (Article X) – Strengthened bilateral relations