Collaborations Advancing Research January 30, 2020 - - PowerPoint PPT Presentation

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Collaborations Advancing Research January 30, 2020 - - PowerPoint PPT Presentation

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Twitter: @BostonUResearch | #researchontap INDUSTRY ON TAP Collaborations Advancing Research January 30, 2020 bu.edu/research/events @BostonUResearch | #researchontap The Art of Industry: Two Strategies for Working with Boston University

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bu.edu/research/events INDUSTRY ON TAP

Collaborations Advancing Research

January 30, 2020

Twitter: @BostonUResearch | #researchontap

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Mark W. Grinstaff Boston University Departments of Biomedical Engineering, Chemistry, and Medicine Division of Material Science and Engineering

The Art of Industry: Two Strategies for Working with Industry

mgrin@bu.edu; http://people.bu.edu/mgrin

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Strategy 1

 Solution or partial solution to a

societal problem identified

 Start-up formed  Stop further research in the lab  Challenges

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Strategy 2

 Partial solution to a societal

problem identified

 Unified goals  Continue research in the lab  Joint meetings and

publications

 Contracts and stipulations  Rights to technology

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Azer Bestavros

Warren Distinguished Professor of Computer Science (Founding Director of the Hariri Institute for Computing) Associate Provost for Computing & Data Sciences

The Red Hat and Honda Research Institute Collaboratories at Boston University

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

Maria A. Kukuruzinska, PhD

Professor and Interim Chair, Department of Translational Dental Medicine Associate Dean for Research, School of Dental Medicine Director, Head and Neck Cancer Program

Collaboration with Eisai, Inc.

Targeting the β-catenin/CBP Axis for the Treatment of Head and Neck Cancer

Collaborative Multidisciplinary Team Science: epithelial and stromal cancer biology, animal models, genomics/epigenomics, molecular biochemistry, in silico analyses

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  • I. Interest to Eisai, Inc.:
  • Collaborative team science, Mechanism of Action, computational expertise, preclinical models;
  • Extensive accumulated basic science and preclinical data (~ 8 published studies from our team:

Sengupta et al., (2010) J Biol Chem; Sengupta, et al, (2013) J Cell Sci;Bais, et al., (2015) Oral Oncology; Hiemer, et al. (2015) Mol Can Res; Vargas, et al., (2016) PLoS Comp Biol; Kartha, et al., (2018) Genome Medicine; Alamoud and Kukuruzinska, (2018) Molecular Determinants of Head and Neck Cancer;)

  • Established collaboration with a medical head and neck cancer oncologist at MGH with a strong

clinical collaboration with Eisai, Inc. on Anaplastic Thyroid Cancer;

  • Routine meetings with Eisai, Inc. leadership scientific and business oncology team at

AACR, ASCO, and local meetings; CDA, 2016; SRA, June, 2019.

  • II. Current Eisai-sponsored Program - the arrangement with Eisai, Inc.:
  • SRA budget: supports partial PI and co-Inv salaries, supplies, animal studies, PhD student research;
  • Collaborative, monthly WebEx conferences with Japan, UK and US;
  • Problems addressed in an expedient and productive manner;
  • Eisai leadership/investigators highly supportive of publication initiatives, very quick turn around

with reviews:

  • 5 abstracts submitted to AACR Annual Meeting 2020
  • 1 manuscript submitted (Mol Omics), 2 in preparation
  • III. Benefits:
  • To Eisai, Inc.: Program addresses need to know (tumor heterogeneity, characterization of

subpopulations of metastatic cells, MOA of E7386 including epigenetics, posttranslational modifications, changes in network connectivities; supports moving E7386 to clinical trials with human patients;

  • To PI and team: Discovery science, generation of extensive data on basic and translational levels

for generation of new hypotheses, future research grant submissions, publications and new program developments.

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

Targeting the β-catenin/CBP Axis for the Treatment of Head and Neck Cancer

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Robert Davey

Professor NEIDL, Microbiology, BUMC

High Throughput Therapeutics at High Containment

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap Infection % Drug concentration

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Doctors without borders

High density anti-viral screening, fast, at BSL4

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

human V mouse C

immunize evaluate mAbs animal testing

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Lessons learnt:

  • 1) Lawyering, 2) confidentiality, 3) need strong admin

support, 4) long time with potentially few publications

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Thomas Bifano

Director BU Photonics Center

Industry Engagement through the Photonics Center

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

Business innovation and industry engagement at BUPC

Core element of BUPC Mission: Translate enabling research discoveries into useful prototypes.

  • ~70 Companies
  • Raised > $650MM
  • Multiple exits, 1 IPO
  • Created > 1000 jobs

New theme: Include big companies with strategic alignment to BUPC (AD, Thor). Continue to support BU and photonic startups.

The Center manages a 6000sf Business Innovation Center, and supports activities related to entrepreneurship and commercialization.

NxTec

The Center regularly leads industry-university collaborations for R&D (I/ UCRC, ERC, GOALI, etc). Recruit fee paying members to ERC innovation ecosystem. Support translational activities and development projects with industry funds ~$250k/yr.

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

CELL-MET Engineering Heart Tissue: $40MM 10Yrs Example: CELL-MET ERC Value chain

Nanostructures Bio-materials Cells Tissue Engr.

  • Engr. Systems

Support Organ-on-Chip Tox/Efficacy Therapeutic Tissue Patches Patient Monitor & Diagnostics

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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David J. Salant

Professor Department of Medicine, BUSM

Commercializing an Immunoassay for an Autoimmune Kidney Disease

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

The Discovery

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Membranous Nephropathy

  • A relatively common autoimmune

kidney disease

  • Autoantibodies damage the filtering unit
  • Proteins leak into the urine
  • Total body swelling
  • May cause kidney failure
  • Kidney biopsy required for diagnosis
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Commercialization

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Intellectual property application filed prior to MS submission – Priority 2008-07-18 • Filed 2009-07-20 • Published 2010-01-21

Soon after publication approach by major healthcare diagnostic company

  • Several months unsatisfactory negotiation - expectations
  • We would have to produce and provide reagents for assay
  • Uncertain experience with developing immunoassays
  • Know-how from our program for 3-5 years
  • Unfavorable milestones

EuroImmun approached us Well-established in developing and marketing diagnostic immunoassays Had developed IFA (BioChip) using rhPLA2R and tested MN patient samples Licensed from BMC and Le Centre National De La Recherche Scientifique

MN serum

rPLA2R+ rPLA2R- rhPLA2R MN Ab

FDA approval July 2014

84% 79% 68% Summary of data submitted to FDA Negative Positive Primary MN Secondary MN Other GN

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Orran Krieger

Professor Electrical and Computer Engineering

The Mass Open Cloud

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

1+ PB

2500 cores, ~40TB RAM Elastic Secure Infrastructure

Cisco Dell Red Hat Intel Two Sigma Lenovo USAF MIT LL IBM Harvard IQSS

  • Block and S3 Object storage
  • Bare Metal Physical machines
  • IaaS – VM, Volume
  • Spark, Hadoop
  • OpenShift: enterprise deployment of Kubernetes container platform:
  • Built in CI, Monitoring, Load Balancing,

400 Power9 Cores, 40 GPUs, 5TB RAM

POWER9 AC922 servers

  • 5.6x CPU to GPU BW vs standard Intel via NVLink 2.0
  • 40 NVIDIA Tesla V100 GPUs delivering up to 5,000 Teraflops for Deep Learning
  • All major open source Deep Learning Frameworks
  • PowerAI Distributed Deep Learning enables AI across multiple servers

It’s real

20+ PB

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

MOC Cloud Research Users OIL OCT Core Partners NERC

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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  • Dr. Kevin “Kip” Thomas

Assistant Professor Anatomy and Neurobiology, School of Medicine

Industry and Academia Partnership Process

Laboratory for Human Neurobiology

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Ongoing Studies Supported by Industry Funding

”MOSAIC” – Monitoring of Scratch via Accelerometry in Children

  • How is sleep impacted by night-time

itch and scratching in Atopic Dermatitis?

”SOC” – Standard of Care

  • Can we detect changes in scratch

behavior and sleep quality in patients with Atopic Dermatitis receiving standards of care treatment?

“Wearable PSG”

  • How accurate is a wearable PSG for

detecting and staging sleep?

“NearFalls”

  • Is there a relationship between sleep

quality and fall risk?

Benefits of Collaboration Academia

  • Funding and support
  • Access to talent and resources
  • Facilitates translation of science to

practical applications

Industry

  • Access to specialized researchers

and scientific knowledge

  • Reduced costs (personnel,

equipment)

  • Increased stability of academic

research

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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HUB/Industry Study Process

 HUB and a Industry company agree on a new study concept  Preliminary study protocol is produced by HUB and delivered to Industry. An IRB is submitted for each study  Working group formed (HUB/Industry team members) to execute and monitor study.  Upon completion of subject assessments a report is written and publications are pursued jointly.

HUB/Industry History

 Ongoing collaborations since 2013  Collaboration began small in scope and expanded  Collaborations developed across various Clinical Departments and Research Laboratories  Studies to date have involved various pathological groups including persons with:  Alzheimer’s Disease  Mild Cognitive Impairment,  Schizophrenia,  Parkinson’s Disease,  Opioid Dependency, Atopic Dermatitis,

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Kate Saenko

Director of the AI Research Initiative Associate Professor Computer Science, CAS

Opportunities in Collaborating with Industry to Advance Artificial Intelligence Research

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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My research:

  • Computer Vision, Machine Learning,

Artificial Intelligence

Why is it interesting to industry?

  • Autonomous cars need to “see”

pedestrians, other cars, etc. (Honda)

  • Digital media creation tools need to

analyze text, images and video (Adobe)

  • HUGE interest from companies!

How did I connect with companies?

  • Hariri Institute
  • PhD student internships

Computer: “vase” Explanation

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Sponsored research:

  • 3 year collaboration with Honda
  • Funds two PhD students
  • Deliverables, joint IP

PhD student internship:

  • Adobe, Google, IBM, NVIDIA
  • So far only Adobe also funded RF (gift)
  • No formal deliverables or contract

HUGE Opportunity! Companies want our AI PhDs!

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Wilson Wong

Associate Professor Biomedical Engineering/College of Engineering

Medical Synthetic Biology

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Senti Biosciences Novartis

CAR T cell therapy High-through Drug Screening Drug inducible cell therapy

Senti Biosciences

(collaboration w/ Mo Khalil)

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Ed Damiano

Professor of Biomedical Engineering College of Engineering

Focusing the Resources of Academia, Industry, Government Agencies, and Non-Profits Through the Lens of Beta Bionics

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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% of people meeting — and not meeting — A1c target

Imagine this possibility:

____ ____ ______ __ ___ _______ ___ _________ ___ _____ ____ __ ____________

Imagine this possibility:

____ ____ ______ __ ___ _______ ___ _________ ___ _____ ____ __ ____________

______ __ _ __ __ __ _______________ ______ _______ __ _______ ___ __ _______________ ___ _______ __ _______ ________ __ ____ _____

6–17 (N = 51) ≥ 18 (N = 165)

__ ____ ____

98% 98% 98% 87% 87% 87%

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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Congratulations

  • Dr. Weining Lu!

Innovator of the Year 2019

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Boston University Slideshow Title Goes Here

@BostonUResearch | #researchontap

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UPCOMING EVENTS

RESEARCH ON TAP

Innovations in Brain Research

February 20, 2020 | 4-6 pm

Initiative on Forced Displacement

March 3, 2020 | 4-6 pm

RESEARCH HOW-TO

Opportunities for Career Training & Development

February 11, 2020 | 3:30-5:30 pm

Strategic Communications: Podcasting 101

February 19, 2020 | 3-5 pm

Learn more & RSVP: bu.edu/research/events Topic ideas & feedback: bu.edu/research/topic-ideas