Coatings for Non-Polymeric Drug Delivery Brent C. Bell David A. - - PowerPoint PPT Presentation

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Sputtered Porous Columnar Coatings for Non-Polymeric Drug Delivery Brent C. Bell David A. Glocker Isoflux Biomed BioInterface 2010 Atlanta, GA October 19, 2010 Isoflux Incorporated Isoflux has unique technology and skills for applying

SLIDE 1

Sputtered Porous Columnar Coatings for Non-Polymeric Drug Delivery

Brent C. Bell David A. Glocker Isoflux Biomed

BioInterface 2010

Atlanta, GA October 19, 2010

SLIDE 2

Isoflux has unique technology and skills for applying inorganic coatings to non-planar shapes using the physical vapor deposition process of sputtering.

Isoflux Incorporated

This includes:

Proprietary coatings
Contract process development
Equipment sales
Coating services
Biomedical coatings

SLIDE 3

Sputtered Nanoporous Coatings for Drug Delivery

Cylindrical Magnetron Cathode

Thornton, High Rate Thick Film Growth, Ann. Rev. Mater. Sci, 1977

Zone 1 Porous Columnar Structure on Complex 3D Shapes

Isoflux ICM10

Equipment Process

SLIDE 4

Porous Columnar Features

Side View

9 mm 12 mm

Top View

7.5 mm Thick Ta SPC Coating

SLIDE 5

SPC Coating Advantages

Excellent adhesion to device
Non-connected columns do not

develop tensile stress

Open and fully connected pore

space allows for easy drug loading

Protective reservoir prevents drug

delamination and high drug load

High surface area of coating

enables long term release

Radiopacity is enhanced (3D)
Biocompatible and low corrosion

materials