Chemspace Fluorine Fragments Description Presence of Fluorine atom - PowerPoint PPT Presentation

Jul 15, 2023 •167 likes •241 views

Chemspace Fluorine Fragments Description Presence of Fluorine atom has been noticed to improve overall ADMET properties, which includes improving metabolic stability and increasing of bioavailability through increasing lipophilicity, decreasing

Chemspace Fluorine Fragments
Description Presence of Fluorine atom has been noticed to improve overall ADMET properties, which includes improving metabolic stability and increasing of bioavailability through increasing lipophilicity, decreasing basic and increasing acidic character of the compound. Fluorinated compounds have different uses: from modulators of the blood pressure and anaesthetics to labeling for the PET screens. But in the Fragment-based drug discovery projects, the major use of fluorinated compounds is 19 F NMR-assisted screening. Fluorine atom shows strong and distinct signal in the NMR spectra. This, and also its sensitivity to local environment changes, allowed usage of the “fragment cocktails” in the NMR studies. Sensitivity of this method allowed screening numerous compounds at the same time without them interfering with each other. Beyond this, with 19 F NMR spectroscopy, structure-activity relationships can be investigated in H2L optimization.
Selection Chemspace Fluorine Fragments library consists of compounds that Comply with Ro3 • Possess single-type fluorine group – enabled usage of the • “fragment cocktails” in NMR studies Library size : 4 942 in-stock compounds 70 574 make-on-demand compounds You can order full set or selected subset based on your criteria; all compounds are supplied as powders, solutions, or dry films. Please contact us at sales@chem-space.com for more information.
Chemspace Compound sets Discover our Fragment Libraries : General Fragments Fluorine and Heavy Fragments • • 3D-Shaped Fragments Selected Fragments • • Acid and Amine Fragments Singleton Fragments • • Covalent Fragments Saturated and Spiro Fragments • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Chemspace Compound sets Discover our Screening compounds : ChEMBL analogs High QED compounds • • CNS-Focused library Phenotypic Screening set • • Covalent Modifiers PPI Modulators • • Drug Impurities Pre-Plated compounds • • Drug Repurposing RNA-Targeted library • • Framework-Derived set Virtual Screening set • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Thank You! The Chemspace Team

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