Breakthroughs in Medical Isotope Technology 2019 Mo-99 Topical - - PowerPoint PPT Presentation

breakthroughs in medical isotope technology
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Breakthroughs in Medical Isotope Technology 2019 Mo-99 Topical - - PowerPoint PPT Presentation

Breakthroughs in Medical Isotope Technology 2019 Mo-99 Topical Meeting Heather Murphy, Commercial Operations Manager BWXT ITG Canada, Inc. BWXT Company Overview 1) As of June 30, 2019 2 Nordion Medical Isotopes Business Acquisition


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SLIDE 1

Breakthroughs in Medical Isotope Technology

2019 Mo-99 Topical Meeting

Heather Murphy, Commercial Operations Manager BWXT ITG Canada, Inc.

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SLIDE 2

BWXT Company Overview

1) As of June 30, 2019

2

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SLIDE 3

Nordion Medical Isotopes Business Acquisition

  • Reputation as a pioneer in reactor and cyclotron

isotope and radiopharmaceutical production

  • Extensive infrastructure – cyclotrons, hotcells,

manufacturing suites, labs

  • 40 year relationship with TRIUMF (Vancouver)
  • Highly trained, experienced, professional staff
  • CNSC-licensed facilities in Kanata, Ontario and

Vancouver, BC

  • World class nuclear transport container fleet
  • Acquisition Closed: July 30, 2018
  • Current Products Include:
  • Iodine-123/Oral Iodine-123
  • Strontium-82
  • Indium-111
  • Palladium-103
  • In-111 oxyquinoline (Q3, 2019)
  • Contract Manufacturing
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SLIDE 4

Tc-99m – A Powerful Diagnostic Tool

Why Tc-99m is so critical?

  • Physiological diagnostic technique
  • Used in 80% of all nuclear medicine imaging

scans, 30-40M patients per year globally

  • Applications in cardiology, GI, oncology,

neurology, pulmonary

  • Considered the gold standard diagnostic test

for many conditions

Over 5,000 lives will be directly impacted by Tc-99m in the next 90 min

How is it made (historically)?

  • Supplied in a Tc-99m generator
  • Decay product of Mo-99
  • Mo-99 produced from the fission of U-

235 targets

  • Targets irradiated primarily in research

and test reactors outside of North America

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SLIDE 5

Mo-99/Tc-99m Market Issues

  • Security of Supply
  • Desire for long term, reliable and locally

manufactured supply

  • Reduction in use of uranium in targets
  • Proliferation risk, inefficient, highly active liquid

waste

  • Sustainable economics along supply chain
  • Nuclear Energy Agency’s High-level Group on

Security of Supply of Medical Radioisotopes (HLG-MR) full cost recovery principle

  • Healthcare System Cost Containment
  • Diagnostic reimbursement pressure
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SLIDE 6
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SLIDE 7

Tc-99m Generator Development

  • Designed to be user friendly
  • Comparable to currently available

generators

  • Sizes (Activity level)
  • Eluent volume and activity

concentration

  • Elution time
  • Dimensions/weight

Tc-99m Generator Prototype

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SLIDE 8

Darlington Nuclear Irradiation Site

  • A world leader in reliable operation of multiple CANDU reactors
  • Proven nuclear safety track record
  • Multiple reactors on one site
  • Longtime producer of radioisotopes – Co-60, Tritium
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SLIDE 9

Progress Update

  • Target Design and Manufacturing
  • Targets designed
  • Manufacturing facility constructed and initial

targets manufactured for testing

  • Target Delivery System
  • Full scale mock-up facility constructed
  • Testing underway
  • Target Processing
  • Processing equipment designed and configured
  • Full scale pilot plant constructed
  • Test runs underway
  • Processing/Manufacturing Facility
  • Hot cell modifications underway
  • New hot cells designed and ordered
  • Tc-99m Generator
  • Finalizing design elements
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SLIDE 10

BWXT Isotope Technologies: Solving the Key Industry Issues Local irradiation, processing and manufacturing

  • Returning North America to a leadership role in

nuclear medicine

  • Leveraging BWXT innovation and former Nordion

assets to de-risk commercialization

  • Securing local supply for North American patients

Uranium-free targets

  • Completely eliminate proliferation risk
  • No long-lived isotopic fission waste

Reliable, redundant irradiation in multiple reactors

  • Utilize highly reliable reactors
  • Predictable, high operating schedule