BL Nanobiomed Printed Biosensors For Healthcare And IoT Applications - PowerPoint PPT Presentation

BL Nanobiomed Printed Biosensors For Healthcare And IoT Applications January 2019 Dr. Varvara Karagkiozaki, MD, MSc CEO Medical Doctor, Cardiologist Expert in Nanomedicine MSc in Nanotechnologies PhD in Nanomedicine

Contents 1. BL NanoBiomed - The Nanomedicine Solution – Products Overview 2. Organic Biosensors & IoT Sensors 3. Strategic Partners: LTFN, OET

BL Nanobiomed • The Company established 01/2014, after 14year R&D in Nanomedicine and Bioelectronics to treat chronic diseases like Cardiovascular Diseases, Cancer, Arthritis, Neurodegenerative ones, Cataract, etc We focus on the: • Development of novel Nanotechnologies for Health • Manufacturing processes for innovative Drug Eluting Nano-systems for site-specific targeted treatment & Biosensors • IPs, Technology licensing and Technology Transfer

Overview of BL NanoBiomed It is a high tech company that applies Nanomedicine and Organic Electronic Technologies and strategies to deal with unmet clinical needs • We know what is needed in clinical practice • We design, develop and validate the Nano-Biosensors into clinical reality Core Activities NanoProducts • Design • Development Biosensors • Prototyping • Production • Commercialization • IPs generation, Technology Consulting and Licensing to 3rd parties • Technology transfer providing integrated solutions for the production of • high added value HealthCare products

Nanoparticles in Nanomedicine Biomedical Nanotechnology presents revolutionary opportunities in the fight against many Diseases… …. such as Cancer, Diabetes, Cardiovascular, Neurodegenerative & Inflammatory/Infectious diseases, Diseases of blood & lungs, Orthopaedic problems, etc Can be applied by using: Various NANOPARTICLES 100 to 10,000 times smaller than human cells & similar in size to large biological molecules e.g. enzymes, cell receptors

NANO-BARRIERS NANO-CARRIERS Haemato-encephalic (blood-brain) Alveolo-capillary (blood-gas) ~10-24 nm ~35 nm Mucosal (GI) <500 nm Renal (kidney, blood-urine) ~ 8-12 nm Skin (dermal) ~ 20-30 nm (flexible)

Products Overview Nanoparticles- Drug Eluting Nanoplatform-Scaffolds-Biosensors 3D Tissue Engineered Nose 200 nm Nanotech-enabled implant for Cartilage Regenaration Nano Stent 3D Tissue Drug Delivery Nanoparticles constructs for Biosensors Nanoplatform Regeneration CONFIDENTIAL

Products Overview 3D BIOPRINTING for Tissue Engineering Grafts APPLICATIONS • Transplantation • In vitro Disease Study • Drug Screening and Discovery In Strong Collaboration With CONFIDENTIAL

Products Overview: Antimicrobial surfaces for Health Applications Antimicrobial surface onto Catheters by Silver NPs • Contamination after implantation of catheters • Solution: Catheters coated with silver using AgNO3 Hospitals • 1 of 20 Hospital patients develops a Hospital- acquired, Antibiotic-resistant infection Coatings for Biomedical Applications • Bacterial adhesion on material surfaces represent a serious problem • Effective Antimicrobial surface coatings that prevents bacteria to adhere, or on bactericidal strategies, killing organisms before contact with the surface

Products Overview Antimicrobial Nanoparticles & Nanosurfaces for Health Applications • Silver and ZnO nanoparticles with unique Antimicrobial properties • NPs onto printable, flexible thin films and nanosurfaces with controlled hydrophobicity and nanotopography  enhance of Antimicrobial & Antibacterial behavior Silver Nanoparticles ZnO Nanoparticles Average Roughness = 18nm Average Roughness = 42nm Average diameter = 30nm Average diameter = 120nm Antimicrobial Nanoparticles onto foley Catheter to avoid urinary tract infection In collaboration with OET CONFIDENTIAL

Contents 1. BL NanoBiomed - The Nanomedicine Solution – Products Overview 2. Organic Biosensors & IoT Sensors 3. Strategic Partners: LTFN, OET

The Internet of Things • Over 6.5 billion devices are connectable to the Internet • By 2020 there will be 20 billion up to 50 billion devices CONFIDENTIAL

Clinical Needs  There is a demand for disposable, simple, cost-efficient, and user-friendly PoC devices with fast response time  The recent growth of IoT and wearables has created the need for electronics and sensors systems that are small, lightweight, mechanically flexible and low-power  These systems must also be able to conform to the shape and survive in the environment  They are typically fabricated on flexible plastic substrates or are printed/woven into fabrics NanoBiosensors CONFIDENTIAL

Futuristic Biosensor OE Sensors and smart sensing systems with unique characteristics: Flexibility, Conformability, Transparency, Biocompatibility, Disposability, Wearability and possibility of Fabrication Over a Large Area CONFIDENTIAL

Trends in Sensor Applications Cardiovascular Disease Diabetes Cancer Source: IDTechEx CONFIDENTIAL

Wearables Local Monitoring & Storage Remote Server Operator Printed electronic tattoo Sensors Communication • Temperature • RFID • Humidity Power Supply • Heart rate • Printed Bat. • Pressure Activation • Acceleration with substrate detachment CONFIDENTIAL

Products Overview Nanoparticles- Biosensors BL focus on the development of Biofunctionalized NPs to detect the biomarkers of a disease for accurate and precise diagnosis Inorganic NPs are valuable tools for a wide range of Biomedical Applications:  Bio-detection  Bio imaging NPs with Biomolecules are used in Detecting  Drug and Gene Transfer  Disease diagnosis Molecular Interactions between Antigens & Antibodies by Biosensors Biofunctionalized AuNPs CONFIDENTIAL

Clinical Need to solve Early detection of heart attack at home with only a drop of blood and send the data to the nearest hospital

Printable Biosensors for heart attack early diagnosis Development of Printable Biosensors  Accurate & Early Detection of heart attack  Use of novel Biomarkers  Integration of NanoMed Technologies with Organic Electronics  Specific Configuration and Biofunctionalization of the Biosensor  Highly Specificity, Linearity in Signal response  Low cost, Mass Production In collaboration with OET Courtesy: LTFN Printed Electrodes CONFIDENTIAL

Acute Diagnosis & Management of Heart Attack Directed Therapies are Time Sensitive !

Advantages of the BL PRINTABLE BIOSENSORs  Integration of NanoMed Technologies with Organic Electronics • Accurate & Early Detection Highly Specificity Linearity in Signal of diseases biomarkers response • At home Low cost Smart Biofunctionalization Mass Production Telemedicine Digital Transferring of data to the hospital CONFIDENTIAL

Contents 1. BL NanoBiomed - The Nanomedicine Solution – Products Overview 2. Organic Biosensors & IoT Sensors 3. Strategic Partners: LTFN, OET

Part of the European Innovative Nanotech Ecosystem Team & Partners • Personnel with high qualified scientific & technical background (medical doctors, engineers, physicists, biochemists) • Strategic Partner: LTFN Nanotechnology Lab of AUTh (http://www.ltfn.gr) & EKNOH • Core member of the Greek Nanomedicine Platform & NanoNet with >600 members worldwide • Core member of HOPE-A • Strategic Collaborations with key players in Nanomedicine field (http://www.etp- nanomedicine.eu/public), hospitals, pharma, implant biomedical companies worldwide • OET: World Leader in Organic Electronics NanoArthoxondros

THANK YOU FOR YOUR ATTENTION!! Dr. Varvara Karagkiozaki vkaragkiozaki@bl-nanobiomed.com