BL Nanobiomed Printed Biosensors For Healthcare And IoT Applications - - PowerPoint PPT Presentation

BL Nanobiomed Printed Biosensors For Healthcare And IoT Applications

January 2019

• Dr. Varvara Karagkiozaki, MD, MSc

CEO Medical Doctor, Cardiologist Expert in Nanomedicine MSc in Nanotechnologies PhD in Nanomedicine

1. BL NanoBiomed - The Nanomedicine Solution – Products Overview 2. Organic Biosensors & IoT Sensors 3. Strategic Partners: LTFN, OET

Contents

BL Nanobiomed

• The Company established 01/2014, after 14year R&D in Nanomedicine and Bioelectronics to treat chronic

diseases like Cardiovascular Diseases, Cancer, Arthritis, Neurodegenerative ones, Cataract, etc We focus on the:

• Development of novel Nanotechnologies for Health
• Manufacturing processes for innovative Drug Eluting Nano-systems for site-specific targeted treatment &

Biosensors

• IPs, Technology licensing and Technology Transfer

• IPs generation, Technology Consulting and Licensing to 3rd parties
• Technology transfer providing integrated solutions for the production of
• high added value HealthCare products

Overview of BL NanoBiomed

It is a high tech company that applies Nanomedicine and Organic Electronic Technologies and strategies to deal with unmet clinical needs

• We know what is needed in clinical practice
• We design, develop and validate the Nano-Biosensors into clinical reality

NanoProducts Biosensors

• Design
• Development
• Prototyping
• Production
• Commercialization

Core Activities

….such as Cancer, Diabetes, Cardiovascular, Neurodegenerative & Inflammatory/Infectious diseases, Diseases of blood & lungs, Orthopaedic problems, etc Can be applied by using: Various NANOPARTICLES Biomedical Nanotechnology presents revolutionary opportunities in the fight against many Diseases…

Nanoparticles in Nanomedicine

100 to 10,000 times smaller than human cells & similar in size to large biological molecules e.g. enzymes, cell receptors

NANO-BARRIERS NANO-CARRIERS

Renal (kidney, blood-urine) ~ 8-12 nm Alveolo-capillary (blood-gas) ~10-24 nm Haemato-encephalic (blood-brain) ~35 nm Mucosal (GI) <500 nm Skin (dermal) ~ 20-30 nm (flexible)

Nanoparticles- Drug Eluting Nanoplatform-Scaffolds-Biosensors Products Overview

Nanoparticles Drug Delivery Nanoplatform 3D Tissue constructs for Regeneration Biosensors

200 nm

3D Tissue Engineered Nose Nanotech-enabled implant for Cartilage Regenaration Nano Stent

CONFIDENTIAL

3D BIOPRINTING for Tissue Engineering Grafts

APPLICATIONS

• Transplantation
• In vitro Disease Study
• Drug Screening and Discovery

Products Overview

In Strong Collaboration With

CONFIDENTIAL

Antimicrobial surface onto Catheters by Silver NPs

• Contamination after implantation of catheters
• Solution: Catheters coated with silver using AgNO3

Hospitals

• 1 of 20 Hospital patients develops a Hospital-

acquired, Antibiotic-resistant infection

Coatings for Biomedical Applications

• Bacterial adhesion on material surfaces represent a serious

problem

• Effective Antimicrobial surface coatings that prevents

bacteria to adhere, or on bactericidal strategies, killing

• rganisms before contact with the surface

Products Overview: Antimicrobial surfaces for Health Applications

Silver Nanoparticles Average Roughness = 42nm Average diameter = 120nm

• Silver and ZnO nanoparticles with unique Antimicrobial

properties

• NPs onto printable, flexible thin films and nanosurfaces

with controlled hydrophobicity and nanotopography  enhance of Antimicrobial & Antibacterial behavior

ZnO Nanoparticles Average Roughness = 18nm Average diameter = 30nm

In collaboration with OET Products Overview

Antimicrobial Nanoparticles & Nanosurfaces for Health Applications

CONFIDENTIAL Antimicrobial Nanoparticles

• nto foley Catheter to

avoid urinary tract infection

1. BL NanoBiomed - The Nanomedicine Solution – Products Overview 2. Organic Biosensors & IoT Sensors 3. Strategic Partners: LTFN, OET

Contents

CONFIDENTIAL

The Internet of Things

• Over 6.5 billion devices are connectable to the Internet
• By 2020 there will be 20 billion up to 50 billion devices

CONFIDENTIAL

Clinical Needs

• There is a demand for disposable, simple, cost-efficient, and user-friendly PoC devices with fast

response time

• The recent growth of IoT and wearables has created the need for electronics and sensors

systems that are small, lightweight, mechanically flexible and low-power

• These systems must also be able to conform to the shape and survive in the environment
• They are typically fabricated on flexible plastic substrates or are printed/woven into fabrics

NanoBiosensors

CONFIDENTIAL

OE Sensors and smart sensing systems with unique characteristics: Flexibility, Conformability, Transparency, Biocompatibility, Disposability, Wearability and possibility of Fabrication Over a Large Area

Futuristic Biosensor

CONFIDENTIAL

Trends in Sensor Applications

Source: IDTechEx

Cardiovascular Disease Diabetes Cancer

Printed electronic tattoo

Sensors

• Temperature
• Humidity
• Heart rate
• Pressure
• Acceleration

Communication

• RFID

Power Supply

• Printed Bat.

Activation with substrate detachment Local Monitoring & Storage Remote Server Operator Wearables

CONFIDENTIAL

Nanoparticles- Biosensors

Products Overview

BL focus on the development of Biofunctionalized NPs to detect the biomarkers

• f a disease for accurate and precise diagnosis

Inorganic NPs are valuable tools for a wide range of Biomedical Applications:

• Bio-detection
• Bio imaging
• Drug and Gene Transfer
• Disease diagnosis

NPs with Biomolecules are used in Detecting Molecular Interactions between Antigens & Antibodies by Biosensors

Biofunctionalized AuNPs

CONFIDENTIAL

Clinical Need to solve Early detection of heart attack at home with

• nly a drop of blood and send the data to the

nearest hospital

Development of Printable Biosensors

• Accurate & Early Detection of heart attack
• Use of novel Biomarkers
• Integration of NanoMed Technologies with Organic Electronics
• Specific Configuration and Biofunctionalization of the Biosensor
• Highly Specificity, Linearity in Signal response
• Low cost, Mass Production

Printed Electrodes

In collaboration with OET

Courtesy: LTFN

Printable Biosensors for heart attack early diagnosis

CONFIDENTIAL

Acute Diagnosis & Management of Heart Attack

Directed Therapies are Time Sensitive!

CONFIDENTIAL

Advantages of the BL PRINTABLE BIOSENSORs

• Accurate & Early Detection
• f diseases biomarkers
• At home

Highly Specificity Linearity in Signal response Low cost Mass Production Smart Biofunctionalization

• Integration of NanoMed Technologies with Organic Electronics

Telemedicine Digital Transferring of data to the hospital

1. BL NanoBiomed - The Nanomedicine Solution – Products Overview 2. Organic Biosensors & IoT Sensors 3. Strategic Partners: LTFN, OET

Contents

Team & Partners

• Personnel with high qualified scientific & technical background (medical doctors, engineers,

physicists, biochemists)

• Strategic Partner: LTFN Nanotechnology Lab of AUTh (http://www.ltfn.gr) & EKNOH
• Core member of the Greek Nanomedicine Platform & NanoNet with >600 members worldwide
• Core member of HOPE-A
• Strategic Collaborations with key players in Nanomedicine field (http://www.etp-

nanomedicine.eu/public), hospitals, pharma, implant biomedical companies worldwide

• OET: World Leader in Organic Electronics

NanoArthoxondros

Part of the European Innovative Nanotech Ecosystem

THANK YOU FOR YOUR ATTENTION!!

• Dr. Varvara Karagkiozaki

vkaragkiozaki@bl-nanobiomed.com