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Biostatistics Hypothesis testing Burkhardt Seifert & Alois Tschopp Biostatistics Unit University of Zurich Master of Science in Medical Biology 1 Testing of hypotheses What does a test do? Due to sample never certainty about

  1. Biostatistics Hypothesis testing Burkhardt Seifert & Alois Tschopp Biostatistics Unit University of Zurich Master of Science in Medical Biology 1

  2. Testing of hypotheses What does a test do? Due to sample − → never certainty about facts: by chance or not? Statistical tests − → decision rules with specified probabilities Introducing examples : Confirmation that therapy A is better than therapy B (difference is not by chance). Aetiologic confirmation for diseases (asbestos, smoking as risk factors for diseases). Evidence for theories, e.g. “emotionally disturbed childhood may lead to mental illness” Master of Science in Medical Biology 2

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