April 30, 2020 Limited published reports No clear evidence at this - - PowerPoint PPT Presentation

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April 30, 2020 Limited published reports No clear evidence at this - - PowerPoint PPT Presentation

Oct 30, 2022 576 likes •663 views

Pediatric COVID 19 April 30, 2020 Limited published reports No clear evidence at this time of vertical transmission from COVID infected mothers Children less affected than adults Symptoms in children are similar with fever and

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Pediatric COVID 19 April 30, 2020

  • Limited published reports
  • No clear evidence at this time of vertical

transmission from COVID infected mothers

  • Children less affected than adults
  • Symptoms in children are similar with fever

and cough most reported

  • May have leukopenia and lymphopenia
  • Variable chest imaging from normal to

ground glass, consolidations, interstitial dis

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Epidemiological Characteristics of 2143 Pediatric Patients with 2019 Coronavirus Disease in China

Methods:

  • Retrospective review of 2143 children reported to

CCDC from 1/16-2/8/2020

  • Series included suspected as well as laboratory

confirmed cases Results

  • 731(34.1%) were lab confirmed; 1412 (65.9%)

were suspected cases

  • Median age 7yrs, similar number of males/females

Dong Y et al Pediatrics, April 2020

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Epidemiological Characteristics of 2143 Pediatric Patients with 2019 Coronavirus Disease in China

Results

  • 94.1% classified as asymptomatic, mild or moderate
  • Severe cases

<1 10.6% 1-5yrs 7.3% 6-10yrs 4.2% 11-15yrs 4.1% death in 14yo >16yrs 3% More severe disease in suspected than confirmed so were some of infants sick with other viruses?

Dong Y et al Pediatrics, April 2020

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Coronavirus Disease in Children- United States, February 12-April 2, 2020

  • 2572/149,760 (1.7%) lab confirmed COVID 19

cases in US were children <18yrs (22% of popul)

  • Mostly from NY and NJ
  • Very limited data reported
  • Median age 11yrs
  • Fewer hospitalizations but there were some
  • 3 deaths (ongoing review to confirm if COVID 19

was likely cause of death) MMWR April 6, 2020

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SLIDE 5

Pediatric COVID 19 April 30, 2020

  • Overall much less severe disease,

hospitalizations and death in children

  • Multiple reports of febrile infants with

COVID 19

  • As US outbreak continues, more

unpublished reports of sick adolescents with some of the risk factors that have been associated with severe disease in adults, particularly obesity

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Pediatric COVID 19 April 30, 2020

  • Maine CDC Pediatric Data (<20yrs)

– 25 confirmed cases 2.3%

Therapy in Children

  • Supportive care; Clinical trials for very ill

– Chiotos et al J Pediatric ID Society

MMC enrolled in studies of 2 drugs

  • Remdesivir

>12yrs;>40kg – iv therapy for up to 10 days

  • Hydroxycholoroquine

>18yrs – placebo controlled oral therapy for 5days

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Pediatric COVID 19 April 30, 2020

  • Dermatologic manifestations

– COVID toes; acute self healing acroischemic lesions reported in fingers/toes of some children during this outbreak (some with +COVID tests)

  • European reports of multisystem

inflammatory state requiring intensive care

– Some features of TSS or Kawasaki disease – Not all COVID +

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Pediatric COVID 19 April 30, 2020