SLIDE 1 Not Final Agenda. Schedule Subject to Change.
AOPT 10th Scientific Meeting February 17 – 20, 2011 • Fort Worth, Texas AGENDA THURSDAY, FEBRUARY 17th
5:00 – 7:00 PM Registration & Welcome Reception
FRIDAY, FEBRUARY 18th
7:00 – 9:00 AM Shuttle Available from the Courtyard Marriott Downtown to UNTHSC 7:30 – 8:00 AM Registration, Exhibits, & Continental Breakfast 8:00 – 8:15 AM Welcome & Opening Remarks 8:15 – 9:00 AM Keynote Address
William Hauswirth, PhD University of Florida College of Medicine “Cone Targeted Gene Therapy”
9:00 – 10:30 AM New Approaches to Drug Delivery Including Nanotechnology
Peter Kador, PhD, Session Co-Chair University of Nebraska Medical Center Hank Edelhauser, PhD, Session Co-Chair Emory University “Transscleral Drug Delivery” Susan Lee, MS University of Southern California “Understanding the Dynamics of Ocular Drug Distribution with 3D MRI” Samirkumar Patel, PhD Georgia Institute of Technology “Targeting to the Surprachoroidal Space of the Eye Using a Hollow Microneedle” Uday Kompella, PhD University of Colorado Denver “Topical Nanosystems for Drug Delivery” James Hill, PhD Louisiana State University Health Science Center “Human Apolipoprotein E (APOE) Mimetic Peptide Inhibits Corneal Neovascularization”
10:30 – 10:45 AM Break & Exhibits 10:45 – 12:15 PM Ocular Inflammation Including Dry Eye & Anti-Infectives
Jerry Niederkorn, PhD, Session Chair University of Texas Southwestern Medical Center “Role of Regulatory T-cells in Promoting Corneal Allograft Survival and Ocular Immune Privilege” Hassan Alizadeh, PhD University of North Texas Health Science Center “The Role of Antimicrobial Peptides at the Ocular Surface” Michelle Callegan, PhD University of Oklahoma Health Science Center “Beneficial Antimicrobial Treatment of Spore-induced Bacillus Cereus Endophthalmitis” Daniel Gamache, PhD Alcon Research Ltd. “Therapeutic Effects of PDE4 Inhibition in Dry Eye”
- L. David Waterbury, MD, PhD
Raven Biosolutions, LLC “Cycloxygenase (COX-1) Versus COX-2 Inhibition to Alleviate Lipopolysaccharide (LPS)-Induced Ocular Inflammation in a Rabbit Model”
12:15 – 1:00 PM Lunch & Exhibits 1:00 – 2:45 PM Animal Models of Ocular Disease
Richard Libby, PhD, Session Chair University of Rochester “Using Mouse Models to Identify Critical Signaling Pathways in Glaucmatous Neurodegeneration” Dennis Rice, PhD Lexicon Pharmaceuticals “Mouse Models of Retinal Vascular Disease” Cathrine Bowes Rickman, PhD Duke University “Anti-amyloid Immunotherapy Blocks RPE Damage and Visual Function Defects in an AMD-like Mouse” Michael Anderson, PhD University of Iowa Health Care “Central Corneal Thickness as an Endophenotype of Glaucoma” Colleen McDowell, PhD University of North Texas Health Science Center “A New Mouse Model of Human Primary Open-angle Glaucoma”
2:45 – 3:00 PM Break & Exhibits
SLIDE 2
Not Final Agenda. Schedule Subject to Change.
3:00 – 4:45 PM Ocular Blood Flow
Jeff Kiel, PhD, Session Chair University of Texas HSC San Antonio “Effect of Phentolamine on Ocular Hydrodynamic Response to Tilt in the Rabbit” Malinda Fitzgerald, PhD, Moderator University of Tennessee Health Science Center Norman Harris, PhD Louisiana State University Health Science Center “Inhibition of 20-HETE Attenuates Streptozotocin-induced Decreases in Retinal Blood Flow” Herbert Reitsamer, PhD Paracelsus University Salzburg “Choroidal Vasodilation in Response to Facial Nerve Stimulation is Frequency Dependent and can be Modulated by L-NAME” Anton Reiner, PhD University of Tennessee Health Science Center “Facial Parasympathetic Circuitry Regulating Choroidal Blood Flow” Oliver Zeitz, MD, PhD Bayer HealthCare “Altered Ocular Perfusion in Glaucoma Patients: The Importance of Methods to Challenge Autoregulation for Clinical Trials” Travis Hein, PhD Texas A&M University “RHO Kinase-Mediated Constriction of Porcine and Human Retinal Arterioles to Endothelin-1”
4:00 – 6:30 PM Shuttle Available from UNTHSC to the Courtyard Marriott Downtown 4:45 – 5:15 PM AOPT Member Business Meeting 4:45 – 6:15 PM Poster Session & Hors D’oeuvres
SATURDAY, FEBRUARY 19th
7:00 – 9:00 AM Shuttle Available from the Courtyard Marriott Downtown to UNTHSC 7:30 – 8:15 AM Registration, Exhibits, & Continental Breakfast 8:15 – 10:00 AM Diabetic Retinopathy
Timothy Kern, PhD, Session Chair Case Western Reserve University “Beneficial Effects of Rate-IG Fusion Protein on Early Diabetic Retinopathy and Tactile Allodynia” Jena Steinle, PhD University of Tennessee Health Science Center “Compound 49B Prevents Neuronal and Vascular Cell Damage in Diabetic Rat” Rose Gubitosi-Klug, MD, PhD Case Western Reserve University “Role of Prostenoids in Diabetic Retinopathy” Jian-Xing Ma, MD, PhD University of Oklahoma Health Science Center “Therapeutic Effect of an Antibody Blocking a WNT Receptor on Diabetic Retinopathy” Yun-Zheng Le, PhD University of Oklahoma Health Science Center “Visulizing and Quantifying Outer Blood-retina Barrier Breakdown: Implications in Finding a Cure for Macular Edema”
10:00 – 10:15 AM Break & Exhibits 10:15 – 12:00 PM Biomarkers for Ocular Diseases & Therapies
John Crabb, PhD, Session Chair and Moderator Cleveland Clinic “Biomarkers for Age-Related Macular Degeneration” Kevin Schey, PhD Vanderbilt University “Maldi Imaging Mass Spectrometry: A New Approach to Biomarker Detection in Ocular Tissues” Yogen Saunthararajah, MD Cleveland Clinic “A Pathway Based Approach to Biomarker Identification in Uveal Melanoma” Kathryn Bollinger, MD Medical College Georgia “Glaucoma Biomarker Discovery using Quantitative Proteomics Analysis of TGF- Beta and Dexamethasone Treated Trabecular Meshwork Cells”
12:00 – 1:00 PM Lunch & Exhibits 1:00 – 2:45 PM Ocular Gene & Stem Cell Therapy
Paul Kaufman, MD, Session Co-Chair University of Wisconsin Abe Clark, PhD, Session Co-Chair University of North Texas Health Science Center Marina Gorbatyuk, PhD University of North Texas Health Science Center “Endoplasmic Reticulum Stress in Retinal Degeneration of P23H Rhodopsin Transgenic Rats” Terete Borras, PhD University of North Carolina “Gene Therapy and Glaucoma”
SLIDE 3
Not Final Agenda. Schedule Subject to Change.
David Gamm, MD, PhD University of Wisconsin “The Prospect of Customized Stem Cell Therapy for Retinal Degenerative Diseases” Gou-Tong Xu, PhD Tongji Eye Institute “Intervention of Retinal Degeneration in Rats with Erythropoietin Gene-modified Mesenchymal Stem Cells”
2:45 – 3:00 PM Break & Exhibits 3:00 – 4:45 PM Macular Degeneration
Joe Hollyfield, PhD, Session Chair Cleveland Clinic Karl Csaky, MD, PhD Retina Foundation of the Southwest “The Role of Retinal Pigment Epithelial Injury in the Development of Geographic Atrophy” Albert Edwards, MD, PhD University of Oregon “Genetic Insights into the Pathogenesis of AMD” Bela Anand-Apte, PhD, MBBS Cleveland Clinic “Regulation of Choroidal Neovascularization by Tissue Inhibitor of Metalloproteinases-3” Robert Mullins, PhD University of Iowa Health Care “The Choriocapillaris in Macular Disease”
4:00 – 5:30 PM Shuttle Available from UNTHSC to the Courtyard Marriott Downtown 6:00 PM Load Bus at the Courtyard Marriott Downtown for Billy Bob’s Texas 6:30 – 12:00 AM
(Buses available to take guests back to the hotel after the dinner at 8:00, 9:00, and 10:00 PM)
Dinner & Entertainment at Billy Bob’s Texas Including a Live Bull Riding Show & Concert by Miranda Lambert
SUNDAY, FEBRUARY 20th
7:00 AM – 12:30 PM Shuttle Between the Courtyard Marriott Downtown & UNTHSC 7:30 – 8:15 AM Registration, Exhibits, & Full Breakfast 8:15 – 10:00 AM New Developments in Glaucoma Therapy
Daniel Stamer, PhD, Session Chair & Moderator University of Arizona Tomi Luan University of North Texas Health Science Center “TGF-BETA 2 Increases Extracellular Matrix Associated Proteins in Cultured Bovine Trabecular Meshwork Cells” David Woodward, PhD Allergan Pharmaceuticals “Rapid Characterization of Functional Prostanoid Receptor Pharmacology in Human Ocular Anterior Segment Cells by Cellular Dielectric Spectroscopy” Carol Toris, PhD University of Nebraska Medical Center “Day and Night Changes in IOP and Aqueous Humor Dynamics of Patients with Ocular Hypertension Treated with Three Glaucoma Drugs” Ganesh Prasanna, PhD Alcon Research, Ltd. “Effect of PF-04217329 a Pro-drug of a Selective Prostaglandin EP2 Agonist on Intraocular Pressure in Preclinical Models of Glaucoma” Craig Crosson, PhD University of South Carolina Medical College “Adenosine Analogs as Ocular Hypotensive Agents”
10:00 – 10:15 AM Break & Exhibits 10:15 – 12:00 PM Neuroprotection
Robert Nickells, PhD, Session Chair University of Wisconsin “Epigenetic Targets for Preventing Neuronal Cell Loss” Adriana Di Polo, PhD University of Montreal “Neuronal and Vascular Protection in Glaucoma: Does Galantamine do the Trick?” Arthur Weber, PhD Michigan State University “Looking Beyond the Eye for Retinal Neuroprotection” Bikash Pattnaik, PhD University of Wisconsin “Potassium Channels, The Apoptotic Volume Decrease, and Neuroprotection” James Randazzo University of Nebraska Medical Center “Evaluation of Orally Active Multi-functional Antioxidants in a Rat Model of Light- Induced Retinal Damage”
12:00 – 12:15 PM Closing Remarks, Evaluations, & Adjourn
SLIDE 4 Not Final List. Accepting Abstracts for Poster Presentations thru Monday, January 17
th.
AOPT 10th Scientific Meeting February 17 – 20, 2011 • Fort Worth, Texas POSTER PRESENTATIONS
Dedicated Poster Viewing Session & Reception Friday, February 18th 4:45 – 6:15 PM New Approaches to Drug Delivery Including Nanotechnology
Mallika Palamoor, PhD University of Tennessee Health Science Center “Biodegradable Polymeric Nanoparticles for Controlled Drug Delivery to the Eye” Damian Berezovsky, MD Emory University Eye Center “In-Vivo Fluorophotometry in Rabbits: Transscleral Delivery of Fluoresceinated Dextrans” Hiroyoshi Kawada, MS University of Nebraska Medical Center “Molecular Parameters Associated with Uptake of Multi-Functional Antioxidants for the Lens, Retina, and Brain”
Ocular Inflammation Including Dry Eye & Anti-Infectives
Bernadette Ibitokun, MBChB, PhD Oklahoma State University Center for Health Sciences “NMDA Mediated Noxious Responses from Rat Cornea” Shawkat Michel, MD, FRCS Ed
“Monoclonal Antibodies in Treatment of Ocular Inflammations and Macular Neovascularization” James Hill, PhD Louisiana State University Health Science Center “Very High Oral Doses of Valacyclovir Significantly Inhibit HSV-1 DNA Shedding into Tears and Saliva of Herpes Simplex Virus Type-1 Latent Rabbits” Angela Herro, MD University of Texas HSC San Antonio “Autologous Serum Tears in Bexar County, TX: Improving Availability and Access”
Animal Models of Ocular Disease
Stephanie Joachim, MD Ruhr University Eye Hospital “Immunoreactivity in Animals with Glaucomatous Retinal Ganglion Cell Loss After Immunization with Retinal Antigens” Weiming Mao, PhD University of North Texas Health Science Center “Perfusion Cultured Bovine Anterior Eye Segments as an Ex Vivo Model for Glaucoma Research” Kim Paes Lexicon Pharmaceuticals, Inc. “Frizzled-4 is Required for Retinal Angiogenesis and Maintenance of the Blood- Retina Barrier” Ankur Jain University of North Texas Health Science Center “Discovery of a Functional Glucocorticoid Receptor Beta-Isoform in the Bovine Trabecular Meshwork” Hai-Ying Ma, MS University of North Texas Health Science Center “Easy and Reliable Genotyping Method for Transgenic Rats”
Devers Eye Institute “IOP Telemetry in Non-Human Primates: Initial Characterization of Continuous IOP at Multiple Time Scales” Peter Kador, PhD University of Nebraska Medical Center “New Mouse Models for Investigating Diabetic Retinopathy”
Ocular Blood Flow
William Lavery University of Texas HSC San Antonio “Effect of Posture on Ocularhydrodynamics in a Rabbit Model”
Diabetic Retinopathy
Claudio Bucolo, PhD University of Catania “Role of Pituitary Adenylate Cyclase-Activating Peptide in Diabetic Retinopathy”
Biomarkers for Ocular Diseases & Therapies Ocular Gene & Stem Cell Therapy
Nitasha Phatak, MBBS, DO University of North Texas Health Science Center “Overexpression of Transcription Factor BRN3B Causes Neurite Outgrowth and Axon Elongation in 661W Cells” Lyn Libertine, MD RXI Pharmaceutical Corp. “Novel Self-Delivering RNAI Compounds (SD-RXRNA) Demonstrate Robust Efficacy in Vitro and in Vivo”
SLIDE 5 Not Final List. Accepting Abstracts for Poster Presentations thru Monday, January 17
th.
Macular Degeneration
Emily Li Brown Alpert Medical School
“In Vitro Coagulation Effects of Ophthalmic Doses of Bevacizumab” New Developments in Glaucoma Therapy
Adnan Dibas, PhD University of North Texas Health Science Center “Production of Human Trabecular Meshwork Cell-Lines Expressing Gralpha and EGFP-GRSS” Anirudh Sethi University of North Texas Health Science Center “TGF Induces Lysyloxidase (LOX) Expression via Smad and Non Smad Signaling in Human Trabecular Meshwork Cells” Naj Sharif, PhD Alcon Research Ltd. “Signal Transduction in Human Iris Cells” Tara Tovar-Vidales, PhD University of North Texas Health Science Center “Human Trabecular Meshwork Cells Express BMP Anatagonist Proteins” Ashley Taylor University of North Texas Health Science Center “Differential Expression of Follistatin and Activin in Normal and Glaucomatous Human Trabecular Meshwork Cells and Tissue” Wanda Medina-Ortiz, MS University of North Texas Health Science Center “Differential Modulation of Cellular Fibronectin Splice Forms Expression by Transforming Growth Factor-Beta 2 in Human Trabecular Meshwork Cells: Possible Mechanism on Extracellular Matrix Remodeling in Glaucoma”
Neuroprotection
Shahid Husain, PhD Medical University of South Carolina “Role of Delta-Opioid Receptor in Retinal Ischemic Preconditioning” Alena Minton University of North Texas Health Science Center “Increased Expression of Endothelin B Receptor and Retinal Ganglion Cell Death in a Rat Model of Ocular Hypertension” Brett Mueller University of North Texas Health Science Center “Sigma-1 Receptor Activation and Mitochondrail Fusion During Hypoxia in Primary Retinal Ganglion Cells” Donald Duadt University of North Texas Health Science Center “Methylene Blue Mediated Protection in Primary Retinal Ganglion Cells” Tim Lam Covance Laboratories “Effect of Morning versus Evening Dosing of 2% Dozolamide on Intraocular Pressure Using Telemetry in New Zealand White Rabbits”
