SLIDE 1 Antoine Andremont
University Paris-Diderot Medical School (France) antoine.andremont@bch.aphp.fr DOI : DaVolterra (French Law Innovation and Research)
SLIDE 2 In a 1945 interview with The New York Times, he warned that misuse of penicillin could lead to the propagation of mutant forms of bacteria that would resist the new miracle drug.
- Prof. Alexander Fleming :
the Nobel Price winner father of the miracle drug
Antibiotics are « miracle, but… » drugs !
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fears resistance
see it
« visible » mortality is still very low…
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The reason is simple: Usually we still do have at least one antibiotic active for each patient
Experts say we can fall anytime !
But no new antiotics + resistance on the rise
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March 11, 2013, G8 Submit UK
SLIDE 6 Mes deux topos de ce jours
1. Où en sommes nous en partique : « matin chagrin » !
- 2. Qu’est-ce qui s’est passé
et comment s’en sortir : « espoir du soir ! »
SLIDE 8 December 6th, 2013
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Last EU economic figures
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Last EU economic figures
Extra- helathcare cost/year due to AMR infections
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In the US too the flag is down…
SLIDE 14 In the US too the flag is down…
Everywhere
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SLIDE 16 38% of blood infections in young cancer patients are ARB Health-care costs of ARB are US $ 21- 34 bn/y
SLIDE 17 CDC has categorized the risks
Gono R-C3G MRSA, ESBL-E,… VRSA, Ere- R Strep A,…
SLIDE 18
While viruses capture more headlines, the greatest risk of hubris to human health comes in the form of antibiotic-resistant bacteria.
SLIDE 19 Portrait imaginaire d’un monde sans antibiotique…
In the hospitals
- Severe Health Care associated infections affecting
- Grafts
- Chemotherapy
- Intensive care
- Neonatal care
In the community
- Resurgence of treatment failure for common infections
- Urinary tract infections
- Staphylococci skin infections
- Enteric diseases
In food producing animals
- Difficulties in intensive production
- Less meat
SLIDE 20 La pan -résistance commence à émerger du « calme antibiotique »
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La balle est entre nos mains !!
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Paraphrasant André Malraux : « …en terme d’antibiothérapie, le XXIème siècle sera écologique ou ne sera pas…. »
