ADAPTABLE: Whats the right dose of aspirin if you have heart - PowerPoint PPT Presentation

ADAPTABLE: What’s the right dose of aspirin if you have heart disease? Adrian F. Hernandez, MD, MHS Vice Dean for Clinical Research, Duke University @texhern September 19, 2019

Presenter Name [Note to presenter: Please use only this slide OR the Disclosures next slide depending on your disclosure information.] Rela latio ionship ip Company ny(ies es) Speakers Bureau Advisory Committee Board Membership NEST Consultancy AstraZeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Merck, Novartis Review Panel Honorarium Ownership Interests 2

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ADAPTABLE Study Design 4

http://adaptablepatient.com 5 5

Adapting to a Computable Phenotype 6

Testing out Best Recruitment Methods 7

The ADAPTORS 8

Engaging a Potential Participant 9 9

Health Care Systems Participating in ADAPTABLE 10 ClinicalTrials.gov: NCT02697916

Adaptable by the Numbers • 657,215 identified as eligible • 450,577 approached • 32,087 Golden Tickets Entered • 15,076 Participants Randomized Across 40 sites in PCORnet Recruiting 5-10X faster 11

Learn More • www.pcori.org • info@pcori.org • #PCORI2019 • adaptablepatient.com 12

Questions? 13

Thank You! Adrian Hernandez Vice Dean for Clinical Research, Duke University @texhern September 19, 2019 14