WP5-6 2 ESR positions at GSI Part 1: Physics Part 2: Biology - - PowerPoint PPT Presentation

Radiobiophysical Measurements for the Extension to other Ions

WP5-6 2 ESR positions at GSI Part 1: Physics Part 2: Biology PARTNER Kick-Off-Meeting

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Motivation 1 - Carbon or Lighter

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Motivation 2 - Something Heavier?

(Michael Scholz)

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Choice of the Right Ion

Protons

• no advantage for radioresistant tumors,
• large lateral scattering

Question: Do other light ions have advantages for special tumors? Carbon + RBE: low in the entrance, enhanced in the tumor + - reduced OER but only on the last mm Heavier Ions

• enhanced RBE in the entrance, more fragmentation

+ reduced OER Question: Is there a heavier ion with reduced OER but tolerable RBE in the entrance?

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WP5 - Physics

T1: Training on experimental techniques for fragmentation experiments D1: Design of exp. setup for new measurements (m6) T2: Measurement of depth dose curves and fragmentation data D2: Report on physical data base (m24) T3: Implementation of the new physical data base into TRiP . D3: Demonstration of a test version of TRiP for the new ions (m36) Collaboration partner: HIT

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WP6 - Biology

T1: Training on radiobiological work with hypoxic cells D1: Report on first OER measurements (m12) T2: Measurement of the RBE-LET and OER-LET dependence D2: Comparison of the gained biological data to model calculations (m24) T3: Extension of the measurements to extended volumes D3: 3:-dimensional biological verification of a treatment plan with the test version of TRiP for the new ions (m36) Collaboration partner: Innsbruck

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Milestones

Physics

• 1. Experimental setup ready (m6)
• 2. Experimental data analyzed (m24)
• 3. Treatment planning for light ion beams (m36)

Biology

• 1. Experimental method established (m12)
• 2. Experimental data analyzed (m24)
• 3. Treatment planning for light ion beams verified (m36)

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