WP5-6 2 ESR positions at GSI Part 1: Physics Part 2: Biology - - PowerPoint PPT Presentation

wp5 6 2 esr positions at gsi part 1 physics part 2
SMART_READER_LITE
LIVE PREVIEW

WP5-6 2 ESR positions at GSI Part 1: Physics Part 2: Biology - - PowerPoint PPT Presentation

Radiobiophysical Measurements for the Extension to other Ions WP5-6 2 ESR positions at GSI Part 1: Physics Part 2: Biology PARTNER Kick-Off-Meeting . p.1/7 Motivation 1 - Carbon or Lighter . p.2/7 Motivation 2 - Something Heavier?


slide-1
SLIDE 1

Radiobiophysical Measurements for the Extension to other Ions

WP5-6 2 ESR positions at GSI Part 1: Physics Part 2: Biology PARTNER Kick-Off-Meeting

. – p.1/7

slide-2
SLIDE 2

Motivation 1 - Carbon or Lighter

. – p.2/7

slide-3
SLIDE 3

Motivation 2 - Something Heavier?

(Michael Scholz)

. – p.3/7

slide-4
SLIDE 4

Choice of the Right Ion

Protons

  • no advantage for radioresistant tumors,
  • large lateral scattering

Question: Do other light ions have advantages for special tumors? Carbon + RBE: low in the entrance, enhanced in the tumor + - reduced OER but only on the last mm Heavier Ions

  • enhanced RBE in the entrance, more fragmentation

+ reduced OER Question: Is there a heavier ion with reduced OER but tolerable RBE in the entrance?

. – p.4/7

slide-5
SLIDE 5

WP5 - Physics

T1: Training on experimental techniques for fragmentation experiments D1: Design of exp. setup for new measurements (m6) T2: Measurement of depth dose curves and fragmentation data D2: Report on physical data base (m24) T3: Implementation of the new physical data base into TRiP . D3: Demonstration of a test version of TRiP for the new ions (m36) Collaboration partner: HIT

. – p.5/7

slide-6
SLIDE 6

WP6 - Biology

T1: Training on radiobiological work with hypoxic cells D1: Report on first OER measurements (m12) T2: Measurement of the RBE-LET and OER-LET dependence D2: Comparison of the gained biological data to model calculations (m24) T3: Extension of the measurements to extended volumes D3: 3:-dimensional biological verification of a treatment plan with the test version of TRiP for the new ions (m36) Collaboration partner: Innsbruck

. – p.6/7

slide-7
SLIDE 7

Milestones

Physics

  • 1. Experimental setup ready (m6)
  • 2. Experimental data analyzed (m24)
  • 3. Treatment planning for light ion beams (m36)

Biology

  • 1. Experimental method established (m12)
  • 2. Experimental data analyzed (m24)
  • 3. Treatment planning for light ion beams verified (m36)

. – p.7/7