SLIDE 17 Applications: molecular biology
Genomes are presented by a permutations:
Ala Arg Asp Asn 1 2 3 Ala Arg Asp Asn
r3
4 4 3 2 1
The evolutionary distance: Palmer, Herbon, 1986
The prefix–reversal distance of two permutations is the least number d of prefix–reversals needed to transform one permutation into another: X: (1, 5, 2, 3, 4) − → Y : (2, 5, 1, 3, 4)
Sorting permutations by reversal (prefix–reversals): NP–hard
Find, for a given permutation π, a minimal sequence d of reversals (prefix–reversals) that transforms π to the identity permutation I.
Elena Konstantinova Two graphs: problems and results Kunming-2013 17 / 20