Title of the Presentation Anna Karpi ska 1, *, Aiva Simaite 1 , and - PowerPoint PPT Presentation

Jun 22, 2023 •314 likes •402 views

Title of the Presentation Anna Karpi ska 1, , Aiva Simaite 1 , and Matej Buzgo 1 1 InoCure s.r.o.; Prmyslov 1960, 250 88 elkovice , Czech Republic Corresponding author: anna@inocure.cz 1 Graphical abstract drug nanofibers mat HV

Title of the Presentation Anna Karpi ńska 1, *, Aiva Simaite 1 , and Matej Buzgo 1 1 InoCure s.r.o.; Průmyslová 1960, 250 88 Čelákovice , Czech Republic * Corresponding author: anna@inocure.cz 1
Graphical abstract drug nanofibers mat HV NEEDLE electrospinning = LOW productivity NEEDLELESS HIGH Electric Field as a key in electrospinning development? DRUG DELIVERY APPLICATION Keywords: needleless electrospinning; electric field; drug delivery; COMSOL Multiphysics; high-throughput 2
Introduction How to increase multineedle system needle the electrospinning productivity? HV cone jet fibers formation collector spinning surface needleless configuration + + + + surface tension + + viscous force + E 3
D d Where are my fibers? Electric Field strength 𝐅 𝐅 How to determine the most efficient systems for drug delivery applications? d d d Electric Field uniformity 𝐯𝐨𝐣𝐠𝐩𝐬𝐧 𝐅 = 𝐯𝐨𝐣𝐠𝐩𝐬𝐧 𝐠𝐣𝐜𝐟𝐬𝐭 𝐞𝐣𝐭𝐮𝐬𝐣𝐜𝐯𝐮𝐣𝐩𝐨 4
Results and discussion Cylinder electrode Wire electrode Slit electrode higher E strength but lower E uniformity higher E uniformity lower E strength but higher E uniformity
Results and discussion Spiral coil electrode Ring coil electrode
Conclusions How to develop the electrospinning system for drug delivery applications? Electric field uniformity Electric field strength Further development ? 7
Acknowledgments 8

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