Title of the Presentation Anna Karpi ska 1, *, Aiva Simaite 1 , and - - PowerPoint PPT Presentation

Title of the Presentation

Anna Karpińska 1,*, Aiva Simaite 1, and Matej Buzgo 1

1 InoCure s.r.o.; Průmyslová 1960, 250 88 Čelákovice, Czech Republic

* Corresponding author: anna@inocure.cz

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Graphical abstract

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Keywords: needleless electrospinning; electric field; drug delivery; COMSOL Multiphysics; high-throughput

HV

nanofibers mat drug

NEEDLE electrospinning = LOW productivity NEEDLELESS HIGH

Electric Field as a key in electrospinning development?

DRUG DELIVERY APPLICATION

Introduction

3 needle collector fibers formation

HV

cone jet E

viscous force surface tension

+ + + + + + +

How to increase the electrospinning productivity?

multineedle system needleless configuration spinning surface

How to determine the most efficient systems for drug delivery applications?

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Electric Field strength

Where are my fibers?

Electric Field uniformity 𝐅 𝐅 D d d d d 𝐯𝐨𝐣𝐠𝐩𝐬𝐧 𝐅 = 𝐯𝐨𝐣𝐠𝐩𝐬𝐧 𝐠𝐣𝐜𝐟𝐬𝐭 𝐞𝐣𝐭𝐮𝐬𝐣𝐜𝐯𝐮𝐣𝐩𝐨

Results and discussion

Slit electrode Cylinder electrode Wire electrode higher E uniformity higher E strength but lower E uniformity lower E strength but higher E uniformity

Results and discussion

Ring coil electrode Spiral coil electrode

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Conclusions

How to develop the electrospinning system for drug delivery applications? Electric field strength Electric field uniformity

Further development ?

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Acknowledgments