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The NIH Human Microbiome Project: An Update Eric Green, M.D., Ph.D. - PowerPoint PPT Presentation

Aug 09, 2023 •192 likes •319 views

The NIH Human Microbiome Project: An Update Eric Green, M.D., Ph.D. Director, NHGRI The NIH Human Microbiome Project (HMP) (HMPI: 2008-2012) (Canada) Sequencing Centers Demonstration Projects Data Analysis & Coordination Center

  1. The NIH Human Microbiome Project: An Update Eric Green, M.D., Ph.D. Director, NHGRI

  2. The NIH Human Microbiome Project (HMP) (HMPI: 2008-2012) (Canada) Sequencing Centers Demonstration Projects Data Analysis & Coordination Center Technology Development Computational Tools ELSI Clinical labs

  3. 1 st Phase of the Human Microbiome Project (HMP1) 6 Initiatives in HMP Community resources Interact through DACC Repositories: HMP1: Survey of the microbiome in humans and 400+ member • sequence data consortium • microbiome  Taxonomic analysis of microbial communities living in/on human body • HMP Consortium human IHMC founding member • strains  Analysis of collective genetic potential in these microbial genomes • www.hmpdacc.org clinical/phenotype data (metagenomics) • nucleic acid extracts • cell lines Healthy cohort study Demonstration Projects Skin: eczema, psoriasis Clinically healthy GI: Crohn’s disease, 300 male/female esophageal 18-40 y.o. adenocarcinoma, necrotizing enterocolitis, pediatric IBS, 18 body sites ulcerative colitis Up to 3 visits in 2 yrs Urogenital: bacterial 16S rDNA, WGS vaginosis, circumcision, metagenomes sexual histories

  4. In adults, each part of the body supports a distinct microbial community All taxon levels PCoA2 (4.4%) PCoA1 (13%) No apparent relationship with gender, age, weight, ethnicity, or race

  5. HMP1 suggests that microbiomes in healthy U.S. adults reflect a global pool of: ~ 10,000 microbial species ~ 8 million unique microbial genes Gevers et al., PLoS (2012)

  6. Key HMP1 Publications (open access) doi:10.1038/nature11234 doi:10.1038/nature11209 doi:10.1038/nature 1209 doi/10.1371/issue.pcol.v01.i13 doi/10.1371/issue.pcol.v01.i13 20+ companion papers

  7. HMP1 Publications and Their Impact 70 160 HMP-Supported Publications 140 60 Citations per Publication 120 50 100 40 80 Median Citations per Publication 30 Number of Publications 60 20 40 10 20 0 0 2009 2010 2011 2012

  8. HMP1-Related Media Inquiries: 2007-2013

  9. What are the 8 million microbial genes doing? DNA RNA Proteins Metabolism

  10. HMP2 (2013-2015): 1) Dataset of microbiome & host genomic and biological properties 2) Community resource 3) Up to $5M/yr, up to 2 awards

  11. Where to go for more information about HMP? http://commonfund.nih.gov/hmp Also – visit NIH Common Fund site for current list of 320+ HMP papers: http://commonfund.nih.gov/hmp/publications.aspx

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