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The IARC Studies and next .. Ib Frandsen Association of Danish - - PowerPoint PPT Presentation
The IARC Studies and next .. Ib Frandsen Association of Danish - - PowerPoint PPT Presentation
The IARC Studies and next .. Ib Frandsen Association of Danish Asphalt Industries 1 In 1994 an unresolved issue Is there a link between exposure to bitumen fume and lung cancer? 2 IARC cohort study 30,000 European asphalt workers Overall
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IARC cohort study
30,000 European asphalt workers Overall mortality below expectation SMR 0,96
No conclusive evidence
Smoking and coal tar major confounders Slightly increased lung cancer mortality SMR 1,17
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Other industries
Asphalt companies
1,000 [1253] controls Inhalation Dermal
IARC NCC study
Does exposure to bitumen fumes cause lung cancer?
350 [433] lung cancer cases
Assessment
- f past exposure
Smoking habits Occupational job history
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It is a global issue
As we saw that the result of a coming IARC Monograph would have an im- mediate Global effect, EAPA contacted NAPA for support to the NCC Study. We got NAPA’s immediate support and subsequently other associations in US have joined as well.
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Result of NCC Study 2009
- The Nested Case Control Study was initiated in 2004 with
the purpose to disentangle the contribution of bitumen, oth- er agents occurring in the asphalt industry, other occupati-
- nal exposures, and tobacco smoking.
- Analyzed 433 lung cancer cases and 1253 controls, mainly
paving workers, from 6 European countries plus Israel.
- Found no evidence of an association between lung
cancer risk and exposure to bitumen fume.
- Two factors which contributed to the slightly elevated inci-
dence of lung cancer mortality observed during the study reported in 2001 were tobacco smoking and coal tar expo- sure.
- The study further acknowledged the importance and re-
sults of the continuous trend towards minimizing inhalation and dermal exposures.
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IARC Monograph
Re-evaluation of the evidence for carcinogenicity of bitumen in 2011/12 Available and peer-reviewed studies Group 1, 2A, 2B or 3
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IARC evaluation
Group 1 Carcinogenic to humans Group 2 A Probably carcinogenic to humans Group 2 B Possibly carcinogenic to humans Group 3 Not classifiable as to its carcinogenicity to ... Group 4 Probably not carcinogenic to humans
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A roadmap towards the monograph process was signed in 2005
Bitumen does not represent a cancer hazard or risk – neither in situ nor in liquid form Focus on occupational exposure to bitumen fumes Recognize differences in exposure from different applications
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IARC Monograph
IARC NCC Study
IARC Monograph re-classification
Fraunhofer Study BGFA Study AI studies in US
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Preparation for the Monograph
Health Forum Dresden and Rome Chapter 1 preparation Research gap identification
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