The Exploding Market Place of Cannabidiol (CBD) The Incredible - - PowerPoint PPT Presentation

The Exploding Market Place of Cannabidiol (CBD)

The Incredible Future Potential & MJNA’s Leading Role

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Brief History of Cannabis

• Cannabis has been part of human evolution since the

beginning of recorded history.

• In ancient Chinese times, cannabis was used as a medicine,

including its oils, tinctures and cannabis-based preparations.

• Today’s presentation concerns the recent developments in

clinical research regarding the re-establishment of “Cannabis as a Medicine”.

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

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1930’s and Cannabis’ Demise

• Up until the late 1930’s cannabis based medications: oils, tinctures and preparations were routinely

used by American doctors and physicians worldwide. The following pictures depict some of the many types of cannabis-based medicinal products that were available.

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Marihuana Tax Act of 1937

• The unfortunate passage of the Marihuana Tax Act of 1937, ended the role of cannabis as a medicine in the

United States – and with the passage of the United Nations Single Convention Treaties of 1961 and 1971 – Cannabis (including hemp) became prohibited throughout much of the world.

• Formerly a part of the US Pharmacopeia – Cannabis was sadly withdrawn as an “accepted” medicine.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabis Research Continued

• In 1937, under the direction of Harry Anslinger, Prohibition

Commissioner of the newly formed Federal Bureau of Narcotics (FBN), cannabis became a banned substance in the US. In 1938, Anslinger convened a meeting of 23 individuals, each of which had some expertise in ‘marihuana.’

• This was a planning meeting to implement prohibition, and an

information session to learn more about the plant.

• There were experts on psychological efgects, on hemp crops, and
• n ‘marihuana’ chemistry.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• Dr. Roger Adams
• From this group came a Dr. Roger Adams, a Harvard educated, renowned organic chemist with

several published papers. Dr. Adams, from University of Illinois and group from 1940 – 1949 carried out 27 studies on cannabis, published in the American Journal of Chemistry. Dr. Adams isolated:

• Cannabinol (CBN)
• Cannabidiol (CBD)
• and Tetrahydrocannabinol (THC)
• Dr. Adams synthesized these cannabinoids.
• Original wholesale formula for CBD 1940

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• Dr. Mechoulam The Grandfather of Modern Cannabis Medicine
• In 1964, with the assistance of Nuclear Magnetic Resonance spectroscopy, Dr. Raphael Mechoulam

also isolated THC then further determined its chemical composition / chemistry.

• Thus Dr. Mechoulam is credited with the discovery and “isolation” of THC – nonetheless Dr. Roger

Adams “inferred THC’s structure” and basically got it right. Further Dr. Adams applied for a patent on CBD isolation going back to 1940 and it was awarded in 1942.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

1940 – Dr. Adams CBD

• http://cannabisdigest.ca/wp-content/uploads/2014/08/roger-adams-in-lab.jpg
• Dr. Roger Adams in his laboratory
• Historical information re Dr. Adams from:

http://cannabisdigest.ca/discovered-thc-setting-record-straight/

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Awards in Organic Chemistry in Dr. Adam’s Name

• Because of Adams signifjcant contributions, in 1959, the Roger Adams

Award was established as an ACS National Award to recognize outstanding contributions to the fjeld of organic chemistry. The award is given every

• ther year where the award address is provided at the National Organic

Chemistry Symposium, which is organized by the ACS Division of Organic Chemistry.

• Roger Adams was inducted as a Laureate of The Lincoln Academy of

Illinois and awarded the Order of Lincoln (the State’s highest honor) by the Governor of Illinois in 1967 in the area of Science. Source: https://en.wikipedia.org/wiki/Roger_Adams

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• Dr. Adams US Patent on the Isolation of Cannabidiol - # 2,304,669
• Dr. Adams great works included a US Patent on the Isolation of

Cannabidiol, US Patent # 2,304,669

• Applied for August 16 1940 and awarded Dec 8 1942.

Link: http://www.google.com/patents/US2304669 Link: https://thecannabus.fjles.wordpress.com/2011/07/2304669- isolation-of-cannabidiol-1942.pdf

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• Dr. Adams Patent on CBD Part II
• From the Abstract:
• “The isolation of cannabidiol from red oil obtained from hemp is described in detail in J. A. C. S. (Journal
• f the American Chemical Society) 62, 196 (1940). This process which includes the treatment of purifjed

red oil with 3,5-dinitrobenzoyl chloride and the formation of cannabidiol bis-3,5-dinitrobenzoate has been found of particular value for the isolation of the desired product. Ammonolysis of the benzoate, i.

• e. diester, yields cannabidiol in pure form.”

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• Dr. Adams on CBD Part III
• “It has been found that from the extracts of hemp (Cannabis sativa or Cannabis indica) that a red viscous
• il can be obtained, commonly known as red oil, from which a pure crystalline compound, cannabidiol,

can be isolated (Adams, Hunt & Clarke J.A.C.S. 62, 196 1940).

• Through a chemical study (J.A.C.S. 62, 196, etc.) it has been shown to have the chemical formula:
• With the exception of the position of the double bond in the left hand cycle of the above formula, the

structure of cannabidiol is well established. Investigations show this left hand cycle to be a tetrahyrdo benzene ring.” Link: https://thecannabus.fjles.wordpress.com/2011/07/2304669-isolation-of-cannabidiol-1942.pdf

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• Dr. Adams Work on Cannabis Places Him on FBI “Watch List”
• Dr. Adams became suspect in the eyes of the FBI because he was doing studies into the chemical

mechanisms by which the plant Cannabis sativa (marijuana) afgects the brain. The plant had been efgectively banned by the passage of the 1937 Marijuana Tax Act. For the purposes of this research Adams had obtained red oil extract of the plant legally from the United States Department of the Treasury. In 1939, this was the main focus of Adams’ work. For these reasons the Offjce of Naval Intelligence said it would never approve security clearance for Adams until World War II.

• Here it became imperative for Dr. Adams to have this high level security clearance as he was instrumental

in developing synthetic rubber for the US Military. Natural rubber supplies to the US had been cut ofg from the Far East by the Japanese during World War II. Adams continued the work of E.K. Bolton (friend from Harvard days) at DuPont and successfully completed the project.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Systems Within The Human Body

• Integumentary System – Skin, Hair, Nails
• Muscular System
• Skeletal System
• Circulatory System – the circulation of blood via arteries,

capillaries and veins

• Nervous System
• Lymphatic System
• Respiratory System
• Endocrine System – hormones

Recognized “systems” within our bodies: Now – an Electrical Circulatory System and hemp can potentially “feed” this system.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Electrical Circulatory System

• A Dr. Bjorn Nordenstrom of the Karolinska Institute in Stockholm

Sweden (where the Nobel Prizes are awarded) has postulated that there is an additional circulatory system within the human body – an Electrical Circulatory System.

• Although we do not plug ourselves into the wall outlet at night,

we do regenerate electrical activity within our nervous system during sleep.

• Dr. Nordenstrom’s books: Biologically Closed Electrical Systems

and his “clifg’s notes”: Biologically Closed Electrical Circuits describe the unexplored world of humans – and give strength to the healing powers of electro-therapy.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

1991 Two German Scientists Win Nobel Prize

• Did you know that two German Scientists won the Nobel Prize

in Medicine in 1991 for their research showing that nutrients enter and depart through the cell membrane in response to the electrical (not chemical) activity of these nutrients?

• Did you know that the body often brings nutrients to areas in

need because of their electrical capabilities to initiate reactions (like enzymes do), rather than for their chemical characteristics?

• Interestingly the electrical nature of hemp and cannabidiol may

be as signifjcant as all the potential chemical benefjts in terms

• f human health and wellness.

Pictured: Erwin Neher (left) and Bert Sakmann (right)

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

CBD, Hemp and Electrical Nutrition

• We are electro-chemical beings. Everything we eat, drink and touch

afgects us electrically.

• Qi (or Chi) is electric energy associated with living organisms.
• Hemp is quite electric – not only in its inspirational attributes, but actually

has been developed into an incredible energy storage technology.

• Chemical engineer, Dr. David Mitlin and research group, have developed

a hemp battery and storage capacitor that may rival the best of science – and for signifjcantly lower cost.

• This development may well revolutionize the way we think about energy

and its storage for generations to come.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

The Body Electric

We routinely measure numerous electrical activities within the human body: We rarely think to treating the human body with the very same electrical signals that we routinely measure – however there is signifjcant evidence that electro-medicine may be one of the next frontiers in the medicine of the future. Cannabidiol from Hemp may play a signifjcant role here. An endogenous cannabinoid, known as Anandamide has shown signifjcant benefjt as a cell signaling molecule.

• The heart and cardiac activity and EKG’s
• The brain and brainwave activity of the EEG’s
• The electro-activity in the muscles, the EMG and
• The electrical conductivity of the nerves in nerve conduction studies.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

1980s Discovery of ECS – Dr. David Allen Reviews

• The Endogenous Cannabinoid System,

discovered in the mid-1980s is far under- recognized for its far-reaching importance.

• This system which regulates balance or

“homeostasis” within us regulates such functions as mood, sleep, appetite and hormone regulation.

• Dr. David Allen has an excellent three-minute

review here.

• The numerous functions of the ECS can be

summarized as “the body’s ability to maintain itself and function in the proper environment”

• Dr. David Allen.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Our Endogenous Cannabinoid System

• The ECS has receptor sites in the brain and central

nervous system (CB1 receptor) and in the viscera, internal organs and gut (CB2).

• It is interesting to note that the CB1 neurotransmitter

receptor in the brain has more receptor sites than the receptor sites for all other neurotransmitters – COMBINED!

• Thus, many researchers now conclude that we humans

(and all mammalian creatures, including horses, dogs, cats, fjsh) are designed to accept plant-based cannabinoids in order to supplement the functioning of this large broadly encompassing self-regulatory system.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Endogenous Cannabinoids

• Anandamide and 2-AG
• FAAH Degrades Endogenous Cannabinoids
• Cannabinoids are responsible for the “Runner’s High” efgect

A release of endogenous cannabinoids and endorphins Endorphins cannot cross the blood-brain barrier, Anandamide crosses BBB Link: http://blogs.scientifjcamerican.com/scicurious-brain/it-hurts-so-good-the-runners-high/

• Cannabinoids are found in Mother’s Breast Milk

A child’s fjrst food contains signifjcant quantities of natural cannabinoids Link: http://www.naturalnews.com/036526_cannabinoids_breast_milk_THC.html

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabinoids

• Extracts from the Cannabis plant family
• CBD, THC and now 80 – 100+ trace cannabinoids
• Can be found in other plants
• Hops
• Echinacea
• Flax
• Kava
• Common Tea
• Endogenous Cannabinoids
• Anamdamide – cell signaling
• 2-AG

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Entourage Efgect

• The hemp plant that we have developed contains 80 – 100

trace cannabinoids and some versions now contain a signifjcant proportion of non-psychoactive Cannabidiol (CBD).

• There are an additional 400 + / - chemicals found in hemp

including terpenoids, fmavonoids, plant waxes, chlorophyll, etc. It stands to reason that some of these chemicals are also found in hemp seed.

• These chemical components in hemp seed, although expressed

in relatively small quantities – all synergistically combine to produce a magnifjed “Entourage Efgect” upon human health and wellness.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Entourage Efgect Part II

The sum of 80 – 100 cannabinoids, many in trace quantities, combined with 400 other plant compounds: terpenoids, fmavonoids, plant waxes, chlorophyll, etc. – all act synergistically to produce an Entourage Efgect as described by

• Dr. Ethan Russo.

The sum total of all these plant compounds working together produces a far greater efgect than a single or double “active ingredient” extraction – which is why the natural botanical version potentially carries greater efgect than the pharmaceutical versions.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Entourage Efgect Part III

• All 500 chemical compounds native in cannabis act

synergistically to produce a far greater efgect than that of single or double active ingredient extraction.

• Thus, natural, botanical cannabinoids and natural,

botanical products may have signifjcantly greater efgects for patients than synthetic, pharmaceutical versions.

• An excellent explanation by Dr. Sanjay Gupta may be

viewed here.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Clinical EndoCannabinoid Defjciency

• There are interesting applications today, as researchers

including Dr. Ethan Russo, a famous cannabinoid researcher, now postulate there is a Clinical Endocannabinoid Defjciency Syndrome and that conditions such as fjbromyalgia, chronic fatigue, irritable bowel syndrome and migraine headache all arise as a result of an internal cannabinoid defjciency.

• Supplementing with plant-based cannabinoids does seem to

have a positive efgect on people’s health and wellness.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Nutrition Against Disease

• At the 2016 European Industrial Hemp Association Conference in Wesseling, Germany we heard from a Dr. Patrick

Collins of Azabu University in Japan. Dr. Collins mentioned that dementia is a relatively new development within Japan and believes that a contributing factor is that hemp and hemp-based cannabinoids have been removed from the Japanese diet since the end of World War II. Currently there are 4 million individuals diagnosed with dementia in Japan and the total is expected to rise to 7 million in the near future.

• Formerly a staple of the Japanese diet, the removal of hemp food products has created a defjcit in essential fatty acids

and a defjcit in plant-based cannabinoids within the Japanese population. The health of the brain, central nervous system and overall nerve function / communication depends signifjcantly on the intake of these essential nutrients. In this case, the removal of essential nutrients from the human body – we see the unfortunate long term efgects on this elderly population.

• Prior to World War II, hemp was a signifjcant crop within Japan. There once were 85 hemp textile factories located

here and the Japanese used to supply hemp textile and other hemp products to the US markets for nearly 100 years. During World War II, the Japanese cut ofg American access to Japan-produced hemp products – which resulted in the now famous US Army’s Hemp for Victory campaign of World War II.

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

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Patients Prefer Natural Botanical Cannabis

• FDA has approved synthetic THC drugs
• Marinol
• Cesamet
• Dronabinol
• Although these are Schedule II or III Drugs and

available via health insurance coverage

• Patients Pay out-of-pocket to purchase medical

cannabis from Dispensaries

Cannabis Legality for Medical Use Lowers Rx Drug Usage

• University of Georgia Professor W. David Branford conducted a

study from 2010 – 2013 on the efgect of medical cannabis in 17 US States and its use for approved indications, including:

• Anxiety, Depression, Glaucoma, Nausea, Pain, Psychosis,

Seizures, Sleep Disorders and Muscular Spasticity.

• Conclusion: Medicare Aged People switched from prescription

drug coverage to medical

• cannabis, saving Medicare part D (Rx Drug Coverage) $165

million.

• Further: if this was nationalized just for these indications, it

would save Medicare nearly

• ½ Billion dollars annually.
• Link: http://www.livescience.com/55309-marijuana-lowers-

prescription-drug-use.html

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Current Cannabinoid Research

Cannabinoids are currently being researched for potential benefjts for:

• Neurological disorders, including epilepsy
• Metabolic Syndrome (Israel)
• Bone healing and Osteoporosis (Israel)
• Depression (Spain)
• Traumatic Brain Injury

Research in the USA via KannaLife Sciences Inc.

• Cancer

Research in the USA via California Pacifjc Medical Center,

• Dr. Sean McAllister
• Alzheimer’s

Research in the US at the Salk Institute on beta-amyloid plaque

• Dr. David Schubert

Link: http://www.salk.edu/news-release/cannabinoids-remove-plaque- forming-alzheimers-proteins-from-brain-cells/ press

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabinoids as Antioxidants and Neuroprotectants

• Potential benefjts for Metabolic Syndrome due to anti-infmammatory benefjts

Heart Cardiovascular Diabetes Rheumatoid Arthritis

• Potential benefjt for Neurological Conditions

Parkinson’s disease Alzheimer’s Multiple Sclerosis, etc.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Neurological Benefjts - Pharma Meds Target Only The Synapse

• Currently, no medicine exists to efgectively cure any

neurodegenerative disease, according to the Institute for Neurodegenerative Diseases.

• In neurology, pharmaceutical medications target the

synapse, wherein the overall neurological network only 2% of all neuronal communication exists. (Source: Electro- Medical Products International).

• Thus the failure of pharma to adequately address

neurological conditions, such as Alzheimer’s, Parkinson’s, depression, neuropathy, etc.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Neurogenesis

• Natural botanical hemp-based CBD seems to carry properties that potentially target a wider range of neuro

activities than just the synapse.

• Dr. Marie Walbridge and artist Syd Fox share their positive experience with CBD in the short documentary,

“Dancing Neurons”.

• CBD seems to be activating the entire neural network – well beyond just the synapse. As increasing

numbers of anecdotal success stories come in, we aim to understand the process further and then fjnd a true “mechanism of action”.

• Natural, botanical hemp-based CBD is being studied by the UCSD Center for Regenerative Medicine for its

stem-cell-like efgects to regenerate new nerves and neuronal cells.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Neurogenesis – Part II

• HempMeds believes that that botanical CBD can potentially increase both synaptic density as well as neuronal

density within the brain.

• The importance of this: the hallmark of Alzheimer’s disease is the loss of synaptic density.
• Should we be able to reverse this and rebuild synaptic density in elderly patients - especially with a natural botanical

remedy that is non-pharmaceutical, no side efgects – this would be a huge step forward in neurological medicine, as well as tremendous for humanity and the future quality of life for many of our senior citizens.

• As shown in animal studies that when synaptic density increases, so does cognition / cognitive function.
• Our goal would be to reverse upwards of 20 years of cognitive aging…!

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

CBD, Neurogenesis and Mitochondrial Function

• The Mechanism of Action (MOA) we feel is linked to

improved mitochondrial function – which we have already seen with CBD. Cannabidiol (CBD) Targets Mitochondria to Regulate Intercellular Calcium Levels. University of Aberdeen, United Kingdom.

• If we are successful future patients may be able to avoid

the long term devastation of Alzheimer’s – saving the US Government healthcare system over $1.1 trillion, as predicted spending on Alzheimer’s is on track for by the year 2050.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

CBD Targets Mitochondrial Function to Regulate Intracellular Calcium Levels

• Anti-aging benefjts, also mentioned in the US

Government patent

• Accelerated Bone Healing – Israel research
• Osteoporosis – Israel Research

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

More re Neuro-Regeneration

• Previous medical thinking stated that we come into the world and by the

age of three months we have a maximum number of brain cells that we carry throughout life.

• Over time, these brain cells deteriorate and this is what causes “Aging”.
• New Age medicine shows that we do actually produce new brain cells

and a Dr. Sandrine Thuret has an excellent Ted Talks presentation re Neurogenesis or Neuro-Regeneration.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

More re Neuro-Regeneration – Part II

• In a recent animal experiment Cannabidiol (CBD) improved neuro-regeneration in the nerve system of adult mice.
• Interestingly enough, THC had no efgect on neuro-regeneration, only CBD activated neuro-regeneration.
• This is in line with other recent fjndings on the pluriform / pluripotent role of the CB1 receptor.
• Pluripotent stem cells have the ability to be programmed to become ANY cell within the human body or

mammalian creature.

• In our estimation, this research shows that natural botanical CBD holds the potential to regenerate nerve and

neurons, which would be a major breakthrough in neurological medicine, anti-aging medicine and overall health & wellness.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• We have seen a recent news release from Mayo Clinic researchers (June 21 2016) who had been studying neurological

trends for the past 30 years and reported their fjndings in JAMA Neurology.

• This report cited the signifjcant increase in Parkinson’s disease and “parkinsonism” particularly in men over the age of

70 years. This is the fjrst study to suggest such a trend, according to researchers.

• Dr. Rodolfo Savica, MD, PhD, the study lead author mentions that “we have evidence to suggest that there has been a

genuine increase in the risk of Parkinson’s disease.” The numbers: For every 10 calendar years of life:

• Men of all ages have a 17% higher risk of developing “parkinsonism”

and

• Men of all ages have a 24% higher risk of developing Parkinson’s disease

Increase in the Occurrence of Neurological Diseases

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Huntington’s Disease/Other Neurological Disorders on The Rise as Well

• The prevalence of Huntington’s disease, another neurological disorder – may need to be revised upwards as genetic

markers point to a statistically signifjcant increase among the general population.

• Although there are numerous stories of sick people and health-challenged children receiving assistance from CBD

– we truly feel that healthy people can take a daily “maintenance regimen” and then potentially avoid some of the potential degenerative risks that are mentioned in the Mayo Clinic’s Parkinson’s article.

• We believe that this trend exists beyond Parkinson’s and into other neurological disorders – as we are continually

challenged by our environment, our excessive usage of cell phones and other factors.

• Please see this article for more on this alarming trend.

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The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

CTE Research

• Kannalife Sciences Inc. is an early stage biotechnology / bio-

pharmaceutical company that holds a license agreement from our US National Institutes of Health to develop a pharmaceutical compound to treat CTE and Traumatic Brain Injury.

• The US Government patent # 6,630,507 (previously discussed)

lists Cannabinoids as Antioxidants and Neuroprotectants.

• Thus our national healthcare researchers believe there is a

strong place for cannabis-based medicine to efgectively treat this unfortunate Traumatic Brain Injury situation.

42

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Research at UCLA Medical Center Torrance, CA

• Research from UCLA Medical Center in Torrance, California

involved 446 young adults who sufgered auto accidents and related traumatic brain injury.

• Interestingly, the regular cannabis users among this

group of young adults were 80% more likely to survive, presumably because their brain cells had that extra layer of neuroprotection that medical cannabis and CBD can provide.

• Research was published in The American Surgeon

Part I

43

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Research at UCLA Medical Center Torrance, CA

• From this we conclude that young high school and college football players, potentially even the NFL football pros

would do well on a course of natural botanical hemp-based CBD therapy.

• Since this is a botanical remedy there there is virtually no downside and the potential to protect brain cells in the

event of a traumatic head injury makes this a type of “second helmet” that is always with the young player.

• While our pharmaceutical development partners work toward a CBD-like medication that will treat those

who have sufgered a severe concussive injury, a natural botanical product is available – that has shown neuroprotective benefjts per the ‘507’ patent.

Part II

44

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabinoids Dissolve Brain Plaques

• Research from the local San Diego Salk Institute shows that cannabinoids reduce Beta-Amyloid Plaques in

human subjects.

• While these exploratory studies were conducted in neurons grown in the laboratory, they might ofger insight

into the role of infmammation in Alzheimer’s disease and could provide novel therapeutics for the disorder.

• Salk Professor David Schubert, the senior author of the study mentions: “Although other studies have ofgered

evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the fjrst to demonstrate that CANNABINOIDS AFFECT BOTH INFLAMMATION and BETA AMYLOID ACCUMULATION in nerve cells.”

Beta Amyloid – Alzheimer’s / Tau – Traumatic Brain Injury (Part I)

45

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabinoids Dissolve Brain Plaques

• Alzheimer’s disease is a progressive brain disorder that leads to memory loss and can seriously impair a

person’s ability to carry out daily tasks.

• It afgects more than 5 million Americans according to the National Institutes of Health and is a leading cause
• f death.
• Alzheimer’s is also the most common cause of dementia and its incidence is expected to TRIPLE during the

next 35 – 50 years.

• Projections from Medicare are that Alzheimer’s treatments will run our National Healthcare System in excess
• f $1 trillion annually by 2050.

Beta Amyloid – Alzheimer’s / Tau – Traumatic Brain Injury (Part II)

46

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabinoids Dissolve Brain Plaques

• Similar to the Beta Amyloid Plaques, but a slightly difgerent form of these brain neurological tangles, is the

Tau Protein.

• Tau protein plaques and accumulation is characteristic of Traumatic Brain Injury, or what Dr. Bennet Omalu

describes as “Chronic Traumatic Encephalopathy” (or CTE).

• CTE has afgected numerous ex-NFL football players and donated brains from deceased ex-NFL players to

Boston University and Dr. Ann McKee have shown that of 91 brain so donated, 87 had strong evidence of these brain plaques characterizing CTE.

Beta Amyloid – Alzheimer’s / Tau – Traumatic Brain Injury (Part III)

47

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabinoids Dissolve Brain Plaques

• A Hollywood movie has been made about the story of Dr. Omalu and his discovery of CTE – that was at fjrst

controversial enough to have the NFL try to discredit Dr. Omalu and his work.

• Science has prevailed in the end – although the experience of Dr. Omalu shows how diffjcult change and

“new concepts” can be for our “establishment” to digest and come to grips with.

• Cannabis is facing similar challenges as basically we have all been lied to, according to Dr. Sanjay Gupta.
• Dr. Gupta has “doubled down” on his stance that cannabis is good for you and certainly with the discovery of

the Endogenous Cannabinoid System and the fact that the US Government holds a patent on the therapeutic usage of cannabinoids shows that “the establishment” is having to re-think their stance on cannabis.

Beta Amyloid – Alzheimer’s / Tau – Traumatic Brain Injury (Part IV)

48

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

As a review, here is a synopsis of Alzheimer’s:

• There are billions of nerve cells in the brain called neurons.
• Neurons transport messages and communication

throughout the brain using electrical signals

• On the surface of the neuron is a protein called Amyloid

Precursor Protein (aka APP)

• Amyloid Precursor Protein (APP) is pulled from the surface
• f the neuron by enzymes
• This frees up a protein called Beta Amyloid
• In a healthy brain, these Beta Amyloid protein fragments are

broken down and eliminated

49

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

As a review, here is a synopsis of Alzheimer’s:

• In brains of people with Alzheimer’s disease, these

fragments accumulate

• These fragments then form sticky, insoluble plaques
• These amyloid plaques accumulate outside the neuron
• These buildups may block cell-to- cell communication at

neuronal junctions, known as synapses

• Synapses are tiny gaps between neurons where signals

(think spark plugs), jump the gap

• Whether beta amyloid plaques cause Alzheimer’s disease

remains controversial

50

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

And now a review of the brain’s lymphatic system, called the Glymphatic system:

• Protein fragments are broken down and/or eliminated via the body’s lymphatic system
• The lymphatic system breaks protein down into individual amino acid components
• These amino acids can be re-combined by the body’s cells to form new proteins
• In the brain, we have a separate lymphatic system known as the Glymphatic system
• This was discovered by University of Virginia at Charlottesville researchers in 2015
• Link: https://www.nih.gov/news-events/nih- research-matters/lymphatic- vessels-discovered-central-nervous- system
• A NIH Link to the research fjnding is found here: http://www.ncbi.nlm.nih.gov/pubmed/25947369

51

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• The Glymphatic system is a waste clearance system
• It promotes the elimination of soluble proteins and metabolites from

the brain

• It promotes similar elimination of protein and metabolites from the

Central Nervous System

• Besides elimination, the Glymphatic system facilitates distribution of

several compounds

• This includes distribution of glucose, lipids, amino acids, growth

factors and neuro-modulators

• This distribution goes to and nourishes all brain and neuronal cells

And now a review of the brain’s lymphatic system, called the Glymphatic system:

52

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
• This system functions mainly during sleep and becomes disengaged during

wakefulness

• Potential neurotoxic waste products, such as beta amyloid are eliminated by

this system

• The Glymphatic system can be suppressed with various diseases
• The failure of the Glymphatic system might contribute to pathology including:
• Neuro-degenerative disorders, traumatic brain injuries, stroke
• And potentially Alzheimer’s disease

And now a review of the brain’s lymphatic system, called the Glymphatic system:

53

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Looking to the future with cannabinoids:

• As of June 2016, the pharmaceutical community was 0 for 190 tries to halt the progressive decline of Alzheimer’s
• In July two additional studies failed – thus we are 0 for 192
• Dr. David Schubert’s work from our local Salk Institute shows promise as:

Cannabinoids afgect both infmammation and beta amyloid accumulation in nerve cells

• Can cannabinoids, by removing both brain infmammation and these beta amyloid plaques, jump-start faulty Glymphatic systems back

toward their proper function…?

• Dr. David Schubert and the Salk Institute are researching…
• Answers for Alzheimer’s, Dementia, Traumatic Brain Injury may be at hand.
• Bloomberg article showing 0 for 190 Tries re Pharma to develop a medication to halt the progression of Alzheimer’s:

http://www.bloomberg.com/news/articles/2016-06-27/after-190-tries-are-we-any-closer-to-a-cure-for-alzheimer-s

• Two recent studies failed in July 2016 re Alzheimers:
• (1) https://www.statnews.com/2016/07/27/alzheimers-drug-taurx/
• (2) http://www.medpagetoday.com/meetingcoverage/aaic/59389
• Dr Schubert’s groundbreaking research re cannabinoids:
• https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/

54

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Epilepsy

Anecdotal evidence shows that CBD can arrest seizures

• 16 US States with CBD-Only Laws so families can stay at home

and not have to move to Colorado

• Clinical Development - GW Pharmaceuticals –
• Epidiolex Shows Positive Phase 3 Trial Results
• 44% Seizure Reduction in Lennox-Gastaut Syndrome Patients

55

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Epilepsy Part II

• Brazil has allowed botanical CBD products for

Refractory Epilepsy

• This is the type that is resistant or unresponsive

to traditional pharma approach

• Potentially will Allow Botanical CBD for Other

Neurological Indications

56

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Metabolic Syndrome

• Studies re Israel, Where Cannabis is Quite Advanced – Sold in

Pharamcies

• Heart
• Cardiovascular
• Diabetes
• Rheumatoid Arthritis
• Above Conditions Show Positive Response to EFAs and DHA
• EFAs Already Proven for Heart and Cardio (Health Canada via Flax

Research)

• Diabetes in the US: 1.7 million new cases are diagnosed each year
• By 2050, 1 in 3 US adults could have diabetes
• Statistics from US CDC
• Link: http://www.cdc.gov/diabetes/pdfs/library/

diabetesreportcard2014.pdf

57

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Metabolic Syndrome – Part II Diabetes Study

• In 2011 an 11,000 patient study representing a cross section of the American population, showed that

marijuana users had a 66% lower incidence of Diabetes. Link: http://bmjopen.bmj.com/content/2/1/e000494. full

• The Beta Cells of the Pancreas Are Responsible for Producing Insulin
• Insulin Maintains Glucose Regulation
• Beta Cells can be Damaged by Oxidative Stress
• Beta Cells can be Damaged by One’s Own Immune System with Dysregulation
• Cannabis Seems to Have a Signifjcant Efgect on Decreasing the Incidence and severity of Diabetes

58

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Diabetes – Dr. David Allen

• CBD in Animal Models Has Shown to Protect the Beta Cells of the Pancreas
• This Has Led to a US Government Patent US 2007 0099987; Filed Feb 16 2005
• Link: http://www.google.com/patents/US20070099987
• If this British Medical Journal Study on 11,000 Patients is Correct, then Cannabis is a miracle Drug
• No Man-Made Pharmaceutical Can Reduce Diabetes by Even 1%
• There Are NO Pharmaceutical Equivalents
• Link: http://cannabisdigest.ca/cannabis-diabetes/

59

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cancer – Anecdotal Evidence Meets Science

• Cancer May Potentially Be Classifjed under Metabolic Syndrome
• Cancer is a “Metabolic Error” within Humans and Animals

60

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Cannabidiol as a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells

• CBD Study Dr. Sean McAllister of California Pacifjc Medical Center
• The Study Shows that CBD Causes programmed Cell Death, known as Apoptosis or
• The Cancerous Cells to Revert Back to their Embryonic, Non-Cancerous Healthy States
• The Mechanism of Action is that CBD Changes Id-1 Gene Expression
• The Id-1 Gene is usually responsible for muscular repair
• In metabolic error the Id-1 gene causes tumor progression
• CBD “switches ofg” this gene expression, thus ending tumor growth
• This occurs even with metastatic (aggressive) forms of cancer
• Study Link: http://mct.aacrjournals.org/content/6/11/292

61

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

CBD Study re Leukemia Dr. McKallip, University of South Carolina

• In the current study, we examined the efgects of the non-psychoactive cannabinoid, Cannabidiol (CBD), on the

induction of apoptosis (programmed cell death) in leukemia cells.

• Exposure of leukemia cells to CBD led to cannabinoid receptor # 2 (CB2) mediated reduction in cell viability and

induction in apoptosis.

• Furthermore, cannabidiol (CBD) treatment led to a signifjcant decrease in tumor burden and an increase in

apoptotic tumors in vivo

• The Mechanism of Action described is via activation of enzymatic pathways known as p22phox NOX4
• Link: http://molpharm.aspetjournals.org/content/70/3/897.full

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol (CBD) in the Regulation of p22phox and NOX4 Expression

62

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Whole Plant Cannabis as a Treatment for Sport Injuries

• Dr. Arno Hazekamp, Dutch Researcher to Lead a Study of 30 ex-NFL Players
• The players will be administered cannabis via vapor or tincture
• Players to be monitored to determine cannabis’ efgectiveness in Alleviating the

players pain

• Alleviating symptoms from repeated sport concussive events
• Link: http://www.denverpost.com/2016/07/07/whole-plant-cannabis-study-

sports-injuries/

63

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

EFAs and DHA Shown to Up-regulate ANK3 Gene and Its Family of Genes

• Hemp, Cannabis Plant Family Member Contains Signifjcant Quantities of Omega 3

Essential Fatty Acids

• DHA – a conditionally essential fatty acid
• The ANK3 Gene and its family afgect Mood, Stress and Longevity
• Researchers at University of Indiana have studied certain human genes that afgect

mood, stress and longevity.

• The researchers have identifjed ANK3 and related genes that serve as biomarkers /

biological links between mood, stress and lifespan.

• These biomarkers may serve as targets for personalized preventative or

therapeutic interventions.

64

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

EFAs and DHA – ANK3 Gene Expression

Part II

• “Bioinformatics drug repurposing analyses revealed a series of

compounds that may act on these genes (ANK3 and related genes) and promote longevity, such as relatively innocuous Omega-3 fatty acid and DHA (docosahexaenoic acid)…” These are fatty acids found in signifjcant quantities in hemp seed!

• The researchers pointed out the accumulating evidence suggesting a

causative link between mitochondrial dysfunction and aging.

• CBD, found in hemp / hemp seed has shown to target mitochondria

and improve cellular effjciency. This has tremendous anti-aging, health and longevity implications.

• CBD and mitochondrial research comes from the University of

Aberdeen in the UK.

65

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

DHA Found in Hemp Increases Neuronal Synaptic Density

• A NIH Study titled: Synapse Formation and Cognitive Brain Development: Efgect of DHA shows that DHA is widely

used in children to diminish the negative developmental and cognitive efgects of premature birth.

• Moreover, DHA and cannabinoids are found in mother’s breast milk.
• DHA in animal models also increased brain levels of all pre- or post- synaptic proteins – an action that is theorized to

involve increasing the gene expression for these proteins.

• Given the fact that Alzheimer’s is characterized by a decrease in synaptic density within the brain, by adding DHA

and cannabinoid-rich hemp oil to one’s dietary intake may make signifjcant inroads toward an accepted therapy for this detrimental condition.

66

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

PTSD & Cannabis Study Finally Gets DEA Approval:

• Link: https://www.leafmy.com/news/headlines/

dea-fjnally-approves-study-on-cannabis- and-ptsd?utm_source=newsletter&utm_ medium=email&utm_content=READ%20FULL%20 STORY&utm_campaign=DD_4.22.16

• Dr. Sue Sisley’s story of many years trying to get this study

past the DEA…

• Signifjes a More Accepting Position of the DEA Toward

Cannabis Research in the US

67

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

Melanoma Cancer Research Approved – Australia, University of Canberra

• Link: https://melanomanewstoday.com/2016/07/07/cannabis-therapy-

for-melanoma-is-goal-of-australian-partnership/

• Australia has the highest rate of Melanoma cancer in the world
• 13,000 New cases to be diagnosed in 2016
• Melanoma is the third most common form of cancer in ANZ
• 1800 people die annually from Melanoma

68

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

DEA to Re-Schedule Cannabis…?

• Potential DEA Re-Scheduling of MMJ which would further ease

restriction re future clinical studies.

• Link: http://www.usatoday.com/story/news/2016/05/21/dea-

could-reschedule-marijuana-allowing-doctors-conduct-more- research/84670716/

• Already in Dec 2015, restrictions toward CBD studies have

been relaxed.

• Link: https://www.dea.gov/divisions/hq/2015/hq122315.shtml

69

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.

US Politics Recognizing the Power of Cannabis

• July 9 2016 – Democrats Call for “Pathway” to Marijuana Legalization
• Link: https://www.washingtonpost.com/news/post-politics/wp/2016/07/09/democrats-call-for-pathway-to-marijuana-

legalization/?utm_source=newsletter&utm_medium=email&utm_content=READ%20FULL%20STORY&utm_campaign=DD_7.11.16

• 2015 Canadian Election of Prime Minister Trudeau focused on the Cannabis issue
• Trudeau was elected because of his favorable-to-cannabis platform
• KSI – License Agreement with NIH

HE / CTE Pre-clinical efgorts have led to molecule KLS-13019

• Alzheimer’s

Tau / Beta Amyloid protein aggregation linked to neurodegenerative pathway 190 Pharma Tries Salk Institute study Loss of Synaptic Density as a Hallmark of Alzheimer’s Efgect of DHA on Synapse Formation & Cognitive Brain Development

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of

• cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.