Tackling issues of in vitro diagnostics for personalized medicine, - PowerPoint PPT Presentation

MOLECULAR PATHOLOGY WG BIOBANKING AND MOLECULAR PATHOBIOLOGY WG Tackling issues of in vitro diagnostics for personalized medicine, SPIDIA4P EUROPEAN PARLIAMENT, 5TH MARCH 2019 Giorgio Stanta Trieste University

European Commission Initiative on Breast Cancer (ECIBC) (Quality Assurance Development Scheme Group) 1. Screening 4. Rehabilitation Screening Complications positive 2. 6. Palliative Recurrent Diagnostic 3. Treatment 5. Follow-up care disease Procedures Symptoms No complications Quality Potential at interface of CLINICAL 2 ° level of processes RESEARCH diagnosis- Sub-group Time: Disease free treatment Information: 2 GDG and QASDG kick-off meetings – 7 to 11 September - Ispra

HIST History of pathology AUT Autopsy pathology INFE Infectious diseases pathology BREAST Breast pathology CARD IT IT in pathology Cardiovascular pathology MOPA Molecular pathology CYTO Cytopathology NEPH DERM Dermatopathology Nephropathology DEVEL Pathology in favour of NEURO Neuropathology developing countries A better and more OPHTH Ophthalmic pathology DIGE-GI Digestive diseases pathology (GI) reproducible molecular diagnosis EM PAED Paediatric and perinatal pathology Electron microscopy PULM Pulmonary pathology ENDO Endocrine pathology SO-TI GYNAE Gynaecological pathology Soft tissue and bone pathology THYM Thymic and mediastinal pathology HAEMA Haematopathology H & N Head and neck pathology URO Uropathology

Increased reproducibility of molecular analyses to increase exchangeability among institutions. Shorter time to apply the new knowledge to patients.

Main factors defining reproducibility in molecular diagnostics and clinical research -Pre-analytical conditions of biological material (SPIDIA4P > CEN > ISO) -Standardizations (SOPs) of methods > European level projects (NGS) -Heterogeneity of tumours > Standardized sampling and liquid biopsies

eMPAm European Molecular Pathology Master European Molecular Pathology Master – Initial Steering Committee “ Michael Hummel (Germany) Aurelio Ariza Fernandez (Spain) ” Marius Ilie (France) Karl-Friedrich Becker (Germany) Andreas Jung (Germany) Serena Bonin (Italy - Secretary) Annette Lebeau (Germany) Leonor David (Portugal) Henrique Rui (Portugal) Ambrogio Fassina (Italy) Ed Schuuring (Netherlands) Falko Fend (Germany) � Giorgio Stanta (Italy - Chair) Pedro L Fernández (Spain) � � Emmanuelle Uro-Coste (France) Gerald Höfler (Austria) � � �