Statin Use and Risk of Breast Cancer: A Meta-analysis of - PDF document

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies Krishna Undela ROP.1.204 Prevention & Early Detection: Oral Communication 1

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies Krishna Undela 1,547,148 citations 1,547,113 citations identified from excluded PubMed and -211,490 review reviewed articles -88,014 clinical trials -303,248 case reports -81,496 letters -24,409 editorials 35 full text studies -838,309 not relevant retrieved for based on title reading detailed evaluation -147 not relevant 2 abstract retrieved based on abstract from ASCO 13 studies excluded -2 exposure was not statin use -9 outcome was not breast cancer incidence 24 studies included -2 studies reported in the meta-analysis on similar population Flowchart representing the selection process Track Disclosure of Prevention & Early Poster number Interest: None Detection: Oral ROP.1.204 Declared Communication 1

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies Krishna Undela Study, Year RR (95% CI) Beck et al., 2003 1.09 (0.93, 1.28) Cauley et al., 2003 0.28 (0.09, 0.86) Graaf et al., 2004 1.07 (0.65, 1.74) Kaye and Jick, 2004 1.30 (1.00, 1.90) Boudreau et al., 2004 1.00 (0.70, 1.20) Friis et al., 2005 1.02 (0.76, 1.36) Eliassen et al., 2005 0.91 (0.76, 1.08) Kochher et al., 2005 0.49 (0.38, 0.62) Cauley et al., 2006 0.91 (0.80, 1.05) Dumasia et al., 2006 0.78 (0.47, 1.31) Boudreau et al., 2007 1.07 (0.88, 1.29) Setoguchi et al., 2007 0.99 (0.74, 1.33) Coogan et al., 2007 1.20 (0.80, 1.80) Friedman et al., 2008 0.99 (0.92, 1.06) Smeeth et al., 2008 1.17 (0.95, 1.43) Pocobelli et al., 2008 1.00 (0.80, 1.20) Haukka et al., 2010 1.01 (0.96, 1.06) Hippisley et al., 2010 1.04 (0.98, 1.11) Woditschka et al., 2010 1.02 (0.97, 1.08) Jacobs et al., 2011 0.98 (0.88, 1.10) Vinogradova et al., 2011 1.00 (0.93, 1.08) Combined estimate ( n = 21) 0.99 (0.94, 1.04) 0.01 0.1 0.2 0.5 1 2 Relative risk (95% confidence interval) Forest Plot Track Disclosure of Prevention & Early Poster number Interest: None Detection: Oral ROP.1.204 Declared Communication 1

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies Krishna Undela No. of Pooled estimate studies RR 95% CI All studies 24 0.99 0.94-1.04 Study design Cohort 13 1.01 0.98-1.04 Case-control 11 0.95 0.84-1.08 Adjusted for n ≥ 8 8 0.99 0.94-1.04 confounders n ≤ 7 16 0.99 0.92-1.06 confounders Bonovas et al . Before 8 1.06 0.95-1.18 After 16 0.98 0.93-1.03 Overall effect estimates Track Disclosure of Prevention & Early Poster number Interest: None Detection: Oral ROP.1.204 Declared Communication 1