Statin Use and Risk of Breast Cancer: A Meta-analysis of - - PDF document

Statin Use and Risk

• f Breast Cancer: A

Meta-analysis of Observational Studies

Krishna Undela

ROP.1.204

Prevention & Early Detection: Oral Communication 1

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies Krishna Undela

Poster number ROP.1.204 Track Prevention & Early Detection: Oral Communication 1 Disclosure of Interest: None Declared

1,547,148 citations identified from PubMed and reviewed 1,547,113 citations excluded

• 211,490 review

articles

• 88,014 clinical trials
• 303,248 case reports
• 81,496 letters
• 24,409 editorials
• 838,309 not relevant

based on title reading

• 147 not relevant

based on abstract 35 full text studies retrieved for detailed evaluation 2 abstract retrieved from ASCO 24 studies included in the meta-analysis 13 studies excluded

• 2 exposure was not

statin use

• 9 outcome was not

breast cancer incidence

• 2 studies reported
• n similar population

Flowchart representing the selection process

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies

0.01 0.1 0.2 0.5 1 2 Combined estimate (n = 21) 0.99 (0.94, 1.04) 1.00 (0.93, 1.08) 0.98 (0.88, 1.10) 1.02 (0.97, 1.08) 1.04 (0.98, 1.11) 1.01 (0.96, 1.06) 1.00 (0.80, 1.20) 1.17 (0.95, 1.43) 0.99 (0.92, 1.06) 1.20 (0.80, 1.80) 0.99 (0.74, 1.33) 1.07 (0.88, 1.29) 0.78 (0.47, 1.31) 0.91 (0.80, 1.05) 0.49 (0.38, 0.62) 0.91 (0.76, 1.08) 1.02 (0.76, 1.36) 1.00 (0.70, 1.20) 1.30 (1.00, 1.90) 1.07 (0.65, 1.74) 0.28 (0.09, 0.86) 1.09 (0.93, 1.28) Relative risk (95% confidence interval) Beck et al., 2003 Cauley et al., 2003 Graaf et al., 2004 Kaye and Jick, 2004 Boudreau et al., 2004 Friis et al., 2005 Eliassen et al., 2005 Kochher et al., 2005 Cauley et al., 2006 Dumasia et al., 2006 Boudreau et al., 2007 Setoguchi et al., 2007 Coogan et al., 2007 Friedman et al., 2008 Smeeth et al., 2008 Pocobelli et al., 2008 Haukka et al., 2010 Hippisley et al., 2010 Woditschka et al., 2010 Jacobs et al., 2011 Vinogradova et al., 2011 Study, Year RR (95% CI)

Forest Plot

Poster number ROP.1.204 Track Prevention & Early Detection: Oral Communication 1 Disclosure of Interest: None Declared

Krishna Undela

Statin Use and Risk of Breast Cancer: A Meta-analysis of Observational Studies

Poster number ROP.1.204 Track Prevention & Early Detection: Oral Communication 1 Disclosure of Interest: None Declared

Krishna Undela

• No. of

studies Pooled estimate RR 95% CI All studies 24 0.99 0.94-1.04 Study design Cohort Case-control 13 11 1.01 0.95 0.98-1.04 0.84-1.08 Adjusted for n ≥ 8 confounders n ≤ 7 confounders 8 16 0.99 0.99 0.94-1.04 0.92-1.06 Bonovas et al. Before After 8 16 1.06 0.98 0.95-1.18 0.93-1.03 Overall effect estimates