Solvotrin Solvotrin is a TCD spin out Developing active iron, - - PowerPoint PPT Presentation

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Sep 22, 2022 431 likes •505 views

Solvotrin Solvotrin is a TCD spin out Developing active iron, aspirin prodrugs, tetracycline nitrates Based in Little Island, Cork Employs ten people between Cork and TCD Founded by Pat OFlynn, John Gilmer, Mark Ledwidge Iron product

SLIDE 1

Solvotrin

Solvotrin is a TCD spin out Developing active iron, aspirin prodrugs, tetracycline nitrates Based in Little Island, Cork Employs ten people between Cork and TCD Founded by Pat O’Flynn, John Gilmer, Mark Ledwidge Iron product ready for launch

SLIDE 2

Background and chronology of Solvotrin

2001- First ‘true’ aspirin prodrug type, 2007- TCD patent filing 38 compounds 2009- Solvotrin formed 2011- New filings patent grants Unimed PLC, 1995-1998 Worked on cardiovascular drug products

Substrate * * Iron?

Do any of the 38 analogues have greater efficacy than aspirin?

Colorectal cancer treatment/prevention

Responses and Problems: Nice technology, but how would you get it approved as a medicine, how much would it cost and what would its value be based on benchmarks?

SLIDE 3

Protein microsphere technology Iron (II) trapped in denatured whey protein Solidified in a stable, protein microcapsule, suitable for solid oral dosage forms

Active Iron™ Platform

P=0.02

10 20 30 40 50 60 70 80 90 100 FeSO4 ST1406 (Scaleup) AUC/Equimolar dose administered

Clinically proven in an RCT Gentle on the stomach, tasteless, non staining, easily taken Lower GI upset not evident

SLIDE 4

Scale-up underway in Germany since early2014 Development in TCD TBSI and in School of Pharmacy with Ann Marie Healy and SFI/AMBER/CRANN Brand, packaging and manufacturing contracts underway, hiring Second manufacturing line operation, validation, Hoffmann Park, Little Island, Ireland, mid-2016

Ongoing Development Work

Active Iron will be used in plain iron products and in a range of pregnancy multi-vitamin products

Solvotrin Solvotrin is a TCD spin out Developing active iron, - - PowerPoint PPT Presentation

Solvotrin

Solvotrin is a TCD spin out Developing active iron, aspirin prodrugs, tetracycline nitrates Based in Little Island, Cork Employs ten people between Cork and TCD Founded by Pat O’Flynn, John Gilmer, Mark Ledwidge Iron product ready for launch

Background and chronology of Solvotrin

2001- First ‘true’ aspirin prodrug type, 2007- TCD patent filing 38 compounds 2009- Solvotrin formed 2011- New filings patent grants Unimed PLC, 1995-1998 Worked on cardiovascular drug products

Do any of the 38 analogues have greater efficacy than aspirin?

Responses and Problems: Nice technology, but how would you get it approved as a medicine, how much would it cost and what would its value be based on benchmarks?

Protein microsphere technology Iron (II) trapped in denatured whey protein Solidified in a stable, protein microcapsule, suitable for solid oral dosage forms

Active Iron™ Platform

Scale-up underway in Germany since early2014 Development in TCD TBSI and in School of Pharmacy with Ann Marie Healy and SFI/AMBER/CRANN Brand, packaging and manufacturing contracts underway, hiring Second manufacturing line operation, validation, Hoffmann Park, Little Island, Ireland, mid-2016

Ongoing Development Work

Active Iron will be used in plain iron products and in a range of pregnancy multi-vitamin products

Solvotrin, future

R&D, Manufacturing in Cork

Challenges? Some Benefits? Lots Enjoy it and work with people you enjoy