Shigeto Kabuki 1 , Hidetoshi Kubo 1 , Kentaro Miuchi 1 , Hiroyuki - - PowerPoint PPT Presentation

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Shigeto Kabuki 1 , Hidetoshi Kubo 1 , Kentaro Miuchi 1 , Hiroyuki - - PowerPoint PPT Presentation

Mar 30, 2024 409 likes •642 views

Shigeto Kabuki 1 , Hidetoshi Kubo 1 , Kentaro Miuchi 1 , Hiroyuki Kimura 2 , Hiroo Amano 2 , Hidekazu Kawashima 3 , Masashi Ueda 3 , Yuji Nakamoto 3 , Kori Togashi 3 , Hideo Saji 2 , and Toru Tanimori 1 1, Department of Physics, Graduate School of

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Shigeto Kabuki1, Hidetoshi Kubo1, Kentaro Miuchi1, Hiroyuki Kimura2, Hiroo Amano2, Hidekazu Kawashima3, Masashi Ueda3, Yuji Nakamoto3, Kori Togashi3, Hideo Saji2, and Toru Tanimori1 1, Department of Physics, Graduate School of Science, Kyoto University;

2, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University; 3, Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University

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S.Kabuki1, K.Hattori, C.Ida, S.Iwaki, H.Kubo, R.Kurosawa, K.Miuchi,

H.Nishimura, J. Pakrer, M.Takahashi,T.Tanimori, K.Ueno, Department of Physics, Kyoto University, Japan H.Kimura, H.Amano, H. Kawashima, H.Saji, M.Ueda Department of Patho-Functional Bioanalysis ,Kyoto University, Japan Y.Nakamoto, T.Okada, K.Togashi Department of Diagnostic Imaging & Nuclear Medicine, Kyoto University, Japan R.Kohara, T.Nakazawa,O.Miyazaki, T.Shirahata, E. Yamamoto Hitachi Medical Corporation, Japan A.Kubo, E.Kunieda, T.Nakahara Department of Radiology, Keio University, Japan K.Ogawa Department of Electronic Informatics, Hosei University,Japan

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Molecular imaging & Motivation Principle of Electron Tracking Compton

Camera

Performance of Electron Tracking

Compton Camera

New drug design for molecular imaging Summary

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Image the morbid life phenomenon and physiology of the living body at molecular level from the outside the body (Radiology, 219 (2001).) Genotype Phenotype

gene

protein enzy me

Action

symptom

Effect of the medicine Molecular probe

Biological molecule Function in the living body

Living body imaging

Enzyme activity Nervous system acceptor

tumor

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New imaging material New Probe

分子プローブ Bio Marker

Visualize

  • PET :E=511keV
  • SPECT :E<300keV
  • New device

Imaging detector Drug design・Clinical application

Molecular Probe

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SLIDE 6

New lots of RI available

  • The development of new RI drug.
  • Long life nuclide, metal nuclide

⇒ visualize the anti body, enzyme, protein reaction

Multi-RI Imaging

  • Simultaneous observation of plural metabolism and interaction

Electron Tracking Compton Camera (ETCC)

: Wide field of view : Wide energy dynamic range

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Electronic track is caught with an original detector (Three patents).

  • An arrival direction of the gamma ray

is calculated for every event.

  • Noise is rejected by momentum and

geometry information α.

α

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ARM SPD

α

TPC：電子の飛跡、 エネルギー Scintillater : 散乱γの位置、 エネルギー

ARM SPD

α

TPC：電子の飛跡、 エネルギー Scintillater : 散乱γの位置、 エネルギー

Electron track Energy Scattered Gamma-ray Position Energy

Simulation result Real data 100 events

Electron Tracking method

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Schematic view of μ-PIC technology

E e

Gas sealed vessel

400mm

μ-PIC Micro Pixel Chamber

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SLIDE 10

10

GSO Pixel

13mm 6 mm

10x10cm2 Camera （GSO or LaBr3）

  • Number of pixels: 576
  • Pixel size 6×6×13mm3

（GSO） 6×6×15, 20mm3 （LaBr3）

  • GSO Enery resolution :10.0 % （@662keV,FWHM)
  • LaBr3 Energy resolution: 6.5% （@662keV,FWHM)
  • Position resolution: 6mm

Black :GSO Red : LaBr3

  • S. Kurosawa Calorimeters IV
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10x10cm2 Camera γ

60cm 180cm 150cm 120cm

30x30cm2 Camera

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Scintillator μTPC μTPC

  • K. Ueno poster C-5
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SLIDE 12

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Simple Back Projection List mode MLEM

List mode Maximum Likelihood Expectation Maximization (Listmode MLEM) 10cm line source 365 keV image

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Ce- 139 Cr- 51 Ba- 133 I- 131 Au- 198 Na- 22 F- 18 Cu- 64 Cs- 137 Mn- 54 Fe- 59 Zn- 65 Co- 60

Energ y [keV]

167 320 354 364 412 511, 1275 511 511 662 835 1095, 1292 1116 1173, 1333

Energy dynamic range : 167 – 1333 keV.

Measured sources

SPECT PET

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Goal in 2009 Spatial resolution vs. Energy

Goal : Same resolution as human PET @ 511keV

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FOV

  • 10

10 50%

Uniformity |x, y|< 7cm ： 11.1% (1σ) 365 keV

10cm 20cm

Uniformity of ETCC

  • Flat Panel size = FOV
  • Energy =365keV

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3cm 3cm

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Molecular Imaging

I-131-5IA nAChRs imaging

Drug Delivery System (DDS)

Au-198-nanoparticles

Double Clinical Tracer Imaging

FDG & I-131-MIBG

High energy nuclide Imaging

Zn-65-porphyrin Imaging

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131 5-[131I]iodo-A85380

I-131-5-IA nAChR imaging

I-131-5IA have been developed by the H. Saji lab for molecular imaging. We performed the imaging of nicotine acetylcholine receptor (nAChR) in the rat central nervous system using I-131-5IA.

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The high accumulation in the brain was visualized.

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Tumor Other organs

Drug carrier

No side effect Inside Drugs Au nano particle Hemoglobin Ribosome TUS Yuasa lab. WEB page

Drug carrier candidates

Drugs

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Application for cancer imaging E.G. Stomach Cancer This probe is available for the stomach cancer that it is hard to detect using FDG. Porphylins accumulation in tumors. Therapy Diagnosis PDT(Photodynamic therapy) PDD(Photodynamic diagnosis)

Porphylin ＋59Fe, 54Mn, 65Zn imaging using ETCC

TUS Yuasa lab. Tsukuba univ. Matsui lab. Koto-ken Nakai lab.

N NH N HN CH3 H3C (CH2)2 COOH (CH2)2 COOH H3C OH CH3 CH3 CH3 HO

hematoporphyrin

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Compton Camera has a wide energy dynamic range

and wide field of view.

We have developed the ETCC camera for molecular

imaging.

Spatial resolution 11mm(FWHM)@511keV Uniformity 11.1% (1σ)

We have studied the new probes for molecular imaging.

I-131-5IA double tracer I-131-MIBG & FDG Au-198 DDS Zn-65-Porphyrin

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