Segetis Renewable Formulation Ingredients for Personal Care 3 rd - - PowerPoint PPT Presentation

Segetis

Renewable Formulation Ingredients for Personal Care

3rd Safer Consumer Products Summit Pre-Summit Workshop: Personal Care Products & Cosmetics September 17, 2013

Renew.Reinvent.Sustain.Change the WorldTM

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Renew We believe that biobased materials are viable alternatives to petrochemicals Reinvent Our disruptive technology will turn Levulinic Acid’s potential as a Biobased Building Block into reality Sustain Supporting sustainable lifestyles with high performance materials that reduce toxicity, air, and environmental impact

Change the World

• Green and Rapidly Growing VC‐funded Specialty Chemistry Company

– Founded in 2006 in MN, USA on the notion of developing Levulinic Acid (LA) and further converting into levulinic ketals as platform materials – Delivering new to the world materials, not green routes to existing molecules

Who is Segetis?

HO OH O O

succinic acid

HO OH O

3-hydroxypropionic acid

OH O NH2 HO O

glutamic acid aspartic acid

OH HO O O NH2 HO OH OH

glycerol

O O HO

4-hydroxybutyrolactone itaconic acid

HO OH O O O O OH

levulinic acid

O O OH O HO

2,5-furandicacboxylic acid

OH OH OH OH OH

xylitol

OH OH OH OH OH OH

sorbitol

HO OH OH OH OH OH O O

glucaric acid

Top 12 US DOE renewable chemicals

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Segetis: Partnering Across the LA Value Chain

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Cellulosic Biomass Sugar

• Renewable feedstocks
• Diverse feedstocks

Levulinic Acid (LA)

• Isolated, high‐purity product
• Thermochemical conversion

Specialty, Renewable Ingredients

• Bio‐based building block

for a >$80 B markets

Segetis’ Breakthrough in Levulinic Acid Technology: Clean, High‐Yield Process

• Despite high level of interest, no large‐scale, cost‐

effective, clean LA production exists today

• Segetis has developed a patented, scalable process

for cost‐effective LA production – High utilization of biomass inputs – Reduced waste – Multiple sugar sources for feedstock flexibility – Demonstrated, economical process

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Cleanest, most economical Levulinic Acid process Cleanest, most economical Levulinic Acid process

Now: Segetis Process Before: Incumbent Process

Char coats equipment Inoperable <<50% yield Char easily rinses >80% yield

What We Do: Specialty Chemicals from Sustainable Feedstocks

From lab scale to commercial sales in 4 years

Family of Products

• Green products competing on

performance

• Markets open to change

O O R2 OR1 O

• Renewable feedstocks
• Diverse feedstocks

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In comparison to petro‐based alternatives: 1. Save 2 gallons of gasoline per gallon of Segetis product 2. Save 7 tons of CO2‐ equivalents per ton of Segetis product

Enhanced Sustainability Profile

3rd Party LCA modeled “field to product” by Boustead Consulting Ltd

7 Calculated on a mixed product portfolio

Color cosmetics

Why we are here today

Hair Care Suncare Nail Care Skincare Makeup Removers

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Broad Solubility

Oil Soluble with what % SG1100D? Soluble with what % SG1200D Stearyl alcohol* 50 50 Stearic acid* 50 50 Castor oil 50 50 Beeswax* 50 50 C12-15 alkyl benzoate 50 50 Isopropyl myristate 50 50 Isopropyl palmitate 50 50 Caprylic/capric triglyceride 50 50 Mineral oil

• 50

Octyl methoxycinnamate 50 50 Cyclomethicone

• 50

Avocado oil 10 50 Sunflower oil 10 50 Almond oil 10 50 Squalene

• 50

Isododecane

• 50

Caprylyl methicone

• 50
• Compatible with many

personal care ingredients

• Can be used in any type of

formulation

Ingredient Soluble with SG1100D Soluble with SG1200D Ethanol Y Y Isopropanol Y Y Water Y N Hydroalcohol Y Y

Segetis solvents can be used in aqueous, alcoholic, or oil phases 9

Dissolves a wide range of ingredients Brings difficult ingredients into formulations Broad compatibility Compatibilizes materials Light, dry emolliency

Physical Characteristics

• Low volatility
• Clear
• Low viscosity
• Compatible with water, hydroalcohol

solutions, alcohols, and oils

Key Functions

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Anti‐aging actives

Trouble‐shooting ingredients

UV actives Polymers Oils & greases Pigments

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Dissolve and Disperse

Brings Difficult Ingredients into Formulations

Solute Demonstrated Solubility in SG1100D (wt %) Demonstrated Solubility in SG1200D (wt %) Avobenzone 20-25 30-40 Oxybenzone 20-25 30-35 Parabens 15-20 Not tested Coenyzme Q10

• 20-22

Retinoic acid

• ~1

Salicylic acid 15-20 11-14 DEET 50 50 Polymer

• Wt. % in

SG1100D

• Wt. % in

SG1200D Nitrocellulose Y Y cellulose acetate butyrate 14 ≥25 acrylate/octylacrylamide copolymer ~5 ~1 PMMA 1 >10

• Increased active loading
• Simplified formulation
• Simplified raw material inventory

Dissolves crystalline actives & polymers High solubility limit Broad substitution range

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Surfactant‐free, naturally‐derived makeup remover

# Phase Trade Name

• Wt. %

1 A SG1200D 29.8 2 A SG1100D 29.8 3 A PROPANEDIOL 39.8 4 A PARABEN DU * 0.6 TOTAL 100

*preservative system is synthetic

Removes waterproof mascara more easily than commercial makeup remover products

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Versatile matchmaker

Expands solubility range of ethanol Expands solubility range of water Brings water into anhydrous systems

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Compatibilizes and Carries

Compatibilizes Ingredients with Alcohols

Expands solubility range in ethanol while maintaining clarity Example: avobenzone in alcohol

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Actives more tolerant to water with SG1100D than with ethanol

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SG1100D ethanol

Lipstick with water (in stick form)

Add 10% water to a lipstick form with no sweating

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• Single formulation ingredient to replace

many specialized ingredients

• Single formulation ingredient to replace

many specialized ingredients

• Troubleshooting ingredient that allows

formulators to expand the range of actives & increase actives concentration

• Troubleshooting ingredient that allows

formulators to expand the range of actives & increase actives concentration

• Robust formulation latitude
• Compatible with many starting formulations
• Robust formulation latitude
• Compatible with many starting formulations
• Incorporates water into anhydrous systems
• Surfactant‐free solubilization
• Expands solubility of ethanol, w/ clarity
• Incorporates water into anhydrous systems
• Surfactant‐free solubilization
• Expands solubility of ethanol, w/ clarity
• Compliment to natural formulations to

reduce greasiness

• Dry, silky after‐feel
• Compliment to natural formulations to

reduce greasiness

• Dry, silky after‐feel

Opportunities to use Segetis ingredients

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Market Status

• Feedback has been very positive

– Segetis’ products bring a very important toolset to formulators – Renewable concept gets traction

• Segetis (and other small renewable chemical companies) need to navigate:

– EU Cosmetic Directive and resistance to animal testing make new innovations difficult

• Global formulation houses tend to formulate globally  new ingredient registrations
• Cannot exceed 1 T in Europe without REACH registration (animal testing required), which

conflicts with – EU cosmetic directive (although recent guidance provides some clarity) – Consumer desire for safe cosmetics with no animal testing

– Fragmented market = high cost to serve

• Many small formulation houses
• Decision‐making is formula by formula

– Specialized formulation know‐how needed

• Awareness of specific formulation challenges
• Understanding of tradeoff balance, other options

Key to success: Strong Partnerships

Advantage to existing ingredients

THANK YOU

Dorie Yontz: 763-795-7257, dorie_yontz@segetis.com

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