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Mary Irvine 1 Robust short-term Stephanie effectiveness of a Chamberlin 1 Rebekkah comprehensive Care Robbins 1 Coordination Program (CCP) Julie Myers 1, 3 in New York City (NYC) Graham Harriman 1 Sarah 1 NEW YORK CITY DEPARTMENT OF HEALTH


  1. Mary Irvine 1 Robust short-term Stephanie effectiveness of a Chamberlin 1 Rebekkah comprehensive Care Robbins 1 Coordination Program (CCP) Julie Myers 1, 3 in New York City (NYC) Graham Harriman 1 Sarah 1 NEW YORK CITY DEPARTMENT OF HEALTH AND Braunstein 1 MENTAL HYGIENE, NEW YORK, NY Beau Mitts 1 2 CUNY SCHOOL OF PUBLIC HEALTH, NEW YORK, NY Sarah Gorrell ‐ Kulkarni 2 3 DIVISION OF INFECTIOUS DISEASES, DEPARTMENT OF MEDICINE, COLUMBIA UNIVERSITY MEDICAL CENTER Denis Nash 2 1

  2. Num umber ber and propor roportion tion of perso sons ns with h HIV in New York rk City y engag gaged d in select ected d stages ges of the e continuu ntinuum m of care e at the end d of 2012 133,635 100% 100% 114,926 86% of 80% 97,940 infected 73% of Percentage infected 60% 72,918 67,624 85% of 55% of 51% of diagnosed 55,453 infected 40% infected 41% of 74% of infected 93% of linked to retained in care 20% 82% of care started on ART 0% Estimated HIV- Ever HIV- Ever linked to Retained in HIV Presumed ever Suppressed viral infected diagnosed HIV care care in 2012 started on ART load (≤200 copies/mL) in Engagement in HIV care 2012 Of all persons estimated to be infected with HIV in NYC, 41% have a suppressed viral load. As reported to the New York City Department of Health and Mental Hygiene by June 30, 2013.

  3. BACKGROUND: PREDICTORS OF SUBOPTIMAL CARE OUTCOMES  Black or latino  Substance use issues race/ethnicity  Stigma  Younger age  Low levels of social  Lower income support  Non-AIDS status  Non-U.S. country of birth  Mental health issues  Unstable housing Torian LV, et. al., AIDS Patient Care STDS 2011. Hsu LC, AIDS Care 2011. Wohl AR, AIDS Behav 2011. Aidala AA, AIDS Behav 2007. Israelski D, Prev Med 2001. 3

  4. BACKGROUND: NYC RYAN WHITE PART A CCP CCP Goal: Ensure that HIV+ Ryan White clients at risk for suboptimal health outcomes receive support to achieve full engagement in care and treatment through coordinated care strategies 4

  5. BACKGROUND: THERE ARE 28 CARE COORDINATION PROVIDER AGENCIES IN NEW YORK CITY 5

  6. BACKGROUND: CCP ELIGIBILITY CRITERIA  CCP targets persons at high risk for suboptimal care outcomes:  newly diagnosed  previously lost to care/never in care  irregularly in care  initiating a new regimen  with incomplete medication adherence or response to treatment 6 6

  7. BACKGROUND: CCP INTERVENTION DESCRIPTION  CCP model provides:  case management  patient navigation, including accompaniment  adherence support, including directly observed therapy (DOT)  health promotion in home visits  assistance with medical/social services 7 7

  8. BACKGROUND: STUDY OBJECTIVES  Assess the effectiveness of this large-scale, multi-site HIV care coordination program in NYC  Compare engagement in care (EiC) and viral load suppression (VLS) in 12 months before and after CCP enrollment  Examine subgroup differences in outcomes* * Subgroups defined based on characteristics at time of enrollment 8

  9. METHODS: DATA SOURCES  Matched CCP eSHARE with NYC HIV Registry data Programmatic Data: Ryan HIV Surveillance Data: White Service Provider Registry of NYC HIV cases Merge Reporting (eSHARE= Electronic (laboratory VL and CD4 tests, System for HIV/AIDS Reporting HIV diagnostic events) and Evaluation) 9

  10. METHODS: ELIGIBLE SAMPLE AND CARE STATUS GROUPS  Clients Eligible for Analysis : enrolled by March 2011, matched to Registry, and alive for ≥ 1 year of follow-up.  Key Te Terms:  Newly Diagnosed: HIV diagnosis date in 12 months before enrollment  Current to Care (Baseline): Any CD4 or VL test date in 6 months before enrollment*  Out of Care (Baseline): No CD4 or VL test date in 6 months before enrollment* *Among the previously diagnosed 10

  11. METHODS: SAMPLE ELIGIBILITY 28 (.7%) clients excluded: did not 3,803 Clients enrolled on or match to the Registry before March 31, 2011 134 (3.5%) clients excluded: died within 12 months of CCP enrollment 3,641 (96.5%) Clients living 12 months post- SAMPLE POPULATION CCP enrollment 465 (12.8%) 2,682 (73.7%) 494 (13.6%) Newly diagnosed at Out of Care at CCP Current to Care at CCP enrollment enrollment CCP enrollment Previously Diagnosed 11

  12. METHODS: STATISTICAL MEASURES  Outcome Measures:  Engagement in Care (EiC): ≥2 CD4 or VL tests ≥90 days apart, with ≥1 in each half of 12-month period  Viral Load Suppression (VLS): VL≤200 copies/mL on most recent test in second half of 12-month period*  Estimated post- vs. pre- CCP enrollment relative risks (RRs) using GEE * Missing VL in 2nd half of 12-month period considered equivalent to unsuppressed VL. 12

  13. METHODS: CCP FOLLOW-UP TIME FOR OUTCOME MEASURES Enrollment Date: Start of follow-up Outcomes: EiC1; VLS1 Baseline: EiC0; VLS0 No VLS Yes VLS 500 ≤ 200 100 days=Yes EiC 200 days=Yes EiC 12 months post-enrollment 12 months pre-enrollment CD4 Lab Viral Load Lab 13

  14. St Study dy Populat ation on Charac racteristi stics cs at CCP Enro rollme ment nt CCP Over veral all N % TOTAL 3,641 100.0 Male 2,286 62.8 Sex Female 1,355 37.2 Black 1,936 53.2 Hispanic 1,393 38.3 Race/ Ra e/Ethn thnicity icity White 204 5.6 Other/Unknown 108 3.0 ≤ 24 224 6.2 Age e (year ars) s) 25 – 44 1,534 42.1 45 – 64 1,767 48.5 65+ 116 3.2 English 2,717 74.6 Primar ary y languag guage e Spanish 736 20.2 Other 188 5.2 US/US dependency 2,403 66.0 Countr ntry of b birth th Foreign country 828 22.7 Unknown 410 11.3 Insured 2,643 72.6 14 Insurance rance Uninsured 998 27.4

  15. St Study dy Populat ation on Charac racteristi stics cs at CCP CCP Over veral all % Enro rollme ment N Homeless 820 22.5 Housing ng statu atus Not Homeless 2,707 74.3 Unknown 114 3.1 < $9,000 1,403 38.5 Househo ehold d income me level vel ≥ $9,000 1,229 33.8 Missing 1,009 27.7 Yes 2,562 70.4 Taking ng ART No 1,079 29.6 <1995 690 19.0 1995 - 2004 1,732 47.6 Year of H HIV Diagno nosi sis 2005 - 2011 1,219 33.5 Yes 1,072 29.4 Viral suppression (≤200 No 2,324 63.8 copies/m es/mL) ) Unknown 245 6.7 < 200 972 26.7 200 - 349 683 18.8 CD4 (cells/ s/ μL ) ) 350 – 499 509 14.0 500+ 692 19.0 15 Unknown 785 21.6

  16. RESULTS: ENGAGEMENT IN CARE, PRE & POST RR=1.06 RR=1.24 ( 95% CI 1.05- 1.08) (95% CI 1.21 - 1.27) 100% 93% 91% 91% 80% 87% h EiC 83% 74% 60% % with 40% 20% 0% N/A 0% Newly diagnosed ALL previously Out of care Current to care diagnosed Among ng previous viously diagnose gnosed 12 months prior to CCP enrollment 12 months post CCP enrollment  Improvements were observed for EiC at 25 (89%) of the 28 agencies 16

  17. Engagement in Care (previously dx’d ): Post- vs. Pre- Enrollment Change, Relative Risk Male le Sex Female RR= Previously Age ≤ 44 44 Dx’d > 45 Insurance 95% CI, Status Insured Previously Unins nsur ured ed Dx’d Housing Status Homeless ess Not Homeless On ART ART Rx Not on ART Year of <1995 Dx 1995-2004 2005 2005-2011 2011 Baseline Yes VLS VL No VLS No 1.24 0.8 1 1.2 1.4 1.6 1.8

  18. RESULTS: VL SUPPRESSION PRE & POST RR=1.34 RR=1.58 100% (95% CI 1.27- 1.4) (95% CI 1.5 - 1.66) 80% 60% 66% h VLS % with 51% 51% 50% 40% 38% 32% 20% 0% N/A 0% Newly diagnosed ALL previously Out of care Current to care diagnosed Among ng previous viously diagnose gnosed 12 months prior to CCP enrollment 12 months post CCP enrollment  Improvements were observed for VLS at 21 (75%) of the 28 agencies 18

  19. Viral Load Suppression (previously dx): Post- vs. Pre- Enrollment Change, Relative Risk ≤ 44 Age RR= > 45 Previously Dx’d <1995 95% CI, Previously Dx’d Year of 1995-2004 Dx 2005 2005-2011 2011 <200 <200 200-349 Baseline CD4 350-499 ≥ 500 1.58 0.8 1 1.2 1.4 1.6 1.8 2 2.2 2.4

  20. LIMITATIONS AND CONSIDERATIONS  Labs are an imperfect proxy for primary care  May overstate care engagement to the extent that some labs reflect acute care vs. primary care visits  Not all primary care visits produce lab data  Ceiling effects may explain some subgroup findings  Certain groups have very little room for improvement  Evolving HIV service and policy landscape 20

  21. CONCLUSIONS  Short-term EiC and VLS improvements were robust across most subgroups examined  Especially among those previously diagnosed and out of care  Newly diagnosed also show promising outcomes  CCP may substantially improve short-term adherence to care and treatment among persons at risk for sub-optimal outcomes 21

  22. ACKNOWLEDGEMENTS  Care Coordination Program Service Providers and Clients  Levi Waldron  Bisrat Abraham  Fabienne Laraque  PACT Staff and Consultants This work was supported through a grant from the Health Resources and Services Administration(H89HA00015) and a grant from NIMH ( 1R01MH101028) entitled “ HIV care coordination: comparative effectiveness, outcome determinants and costs” (CHORDS study). 22

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