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RNAi Triggers for Agriculture RNA on target What we do and why - - PowerPoint PPT Presentation
RNAi Triggers for Agriculture RNA on target What we do and why - - PowerPoint PPT Presentation
RNAi Triggers for Agriculture RNA on target What we do and why NanoSUR develops proprietary, potent RNA materials that selectively target pests in a crop and produce a yield improvement at lower treatment costs Without modifying the crops
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About NanoSUR
Madison Mia iami
NanoSUR originated with a group of world-class biology and chemistry experts in all things RNAi who realized that Agriculture applications could be scaled up by addressing RNA delivery to its targets
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Team Members
- D. LEWIS Ph.D.
CSO
- J. ARHANCET Ph.D.
CEO
- C. HUCK
DIRECTOR, Bus. Dev.
- G. ARHANCET Ph.D.
President
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- D. ROZEMA Ph.D.
VP-Chemistry
- A. FEHRETDINOV
CFO
- V. TRUBETSKOY Ph.D.
DIRECTOR, Formulation
- K. KOGEL Ph.D.
ADVISOR, Phytopathology
- I. GATTI Ph.D.
ADVISOR, Regulatory
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Market Opportunity
Crop Protection
- Dia
Diamondback moth ,$1.3 billion/year, globally
- Soybean aphid, $2.4
billion/year, USA
- Red imported fire ant,
$1.2 billion/year, globally
- Fusarium head blight of
wheat & barley, $0.84 billion/year, USA
- Gibberella corn stalk and
ear rots, $0.38 billion/year, USA
Aquaculture
- White spot syndrome virus
- f shri
rimp, >$0.9 billion/yr
- Sea lice of salmon, >$0.5
billion/yr
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Business Model & Fin inancing
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Product Development
$225K (2017-2018) NSF Phase I for POC $750K (2019-2021) NSF Phase II for DBM $....K (2019-2020) Other Phase I Opportunities from NSF & USDA for FG & RIFA, PA
Licensing
- by sequence
- by pest/parasite
- by host
- by geography
- r Exit by acquisition
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Chall llenges of Curr rrent Envir ironmental RNAi
Current RNAi triggers are efficacious on a limited number of targets Current RNAi triggers have limited stability and inefficient delivery This results in extremely high concentrations needed to control pests in the field
- High cost of applications
- Potential loss of selectivity
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POC achieved: MdsRNAs show high biological activity IP estate covers
- compositions of matter
- methods of manufacture
- methods of use & formulations
First application allowed (Number 15/803,948, USPTO)
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Low cost dsRNA Knowledge base on chemically modified RNA NanoSUR’s process NanoSUR’s MdsRNAs
NanoSUR’s solution: Modified dsRNA (MdsRNA)
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NanoSUR’s PRODUCTS CHEMICAL PIP (TRANSGENIC) BIOPESTICIDES
Market size
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- Pest resistance costs
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- Time to market
+
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Off-target effects
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AGRICULTURE Value Proposition & Competition
Improved crop yields & lower costs to control pests, through higher efficacy & selectivity, and better pesticide resistance management than attained using current pesticides in the market We don’t modify the crop’s genome
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In summary …
NanoSUR brings a Proprietary Platform for RNAi Applications in Agriculture
- Cost-effective and scalable methods to produce MdsRNAs
- Designed to improve deliverability and stability
- Properties of each of NanoSUR’s MdsRNAs can be can be
tailored to target each type of pest/application
Proof of concept achieved in a fungus and insects from three orders, with additional targets planned
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