RESEARCH AGENDA: PERSPECTIVE FROM ACADEMIA (Hypothesis Driven) - - PowerPoint PPT Presentation

▶
research agenda perspective from academia
SMART_READER_LITE
LIVE PREVIEW

RESEARCH AGENDA: PERSPECTIVE FROM ACADEMIA (Hypothesis Driven) - - PowerPoint PPT Presentation

Oct 22, 2022 185 likes •294 views

RESEARCH AGENDA: PERSPECTIVE FROM ACADEMIA (Hypothesis Driven) Eugene O. Major, Ph.D. NIH/NINDS Laboratory of Molecular Medicine & Neuroscience Background 2 JC virus is a very difficult agent to work with Research will continue but

slide-1
SLIDE 1

RESEARCH AGENDA: PERSPECTIVE FROM ACADEMIA

(Hypothesis Driven)

Eugene O. Major, Ph.D. NIH/NINDS Laboratory of Molecular Medicine & Neuroscience

slide-2
SLIDE 2

Background

JC virus is a very difficult agent to work with

Research will continue but move slowly compared with more conventional agents

New research approaches may be needed such as coordinated technologies and ‘team’ investigations, that direct ‘translational’ work.

2

slide-3
SLIDE 3

Recommended Research Areas

Research approaches

Molecular genomics/proteomics; virus and host

Viral gene regulation in specific cells i.e. glia vs neuron

Immunology of therapies and host response to infection

Drug Discovery

Small molecules for intervention of viral growth once identified; relevant cell model for screen

Vaccines, peptides, VLPs (like papilloma virus)

Prophylactic

Therapeutic

Pre-clinical studies/clinical studies

Relevant animal model for pathogenesis and intervention

3

slide-4
SLIDE 4

Human CNS Multipotential Progenitor Cells

4

Nestin

Differentiated Neuronal Cells

Β-III Tubulin O4/GFP

Differentiated Oligodendrocytes

GFAP

Differentiated Glial Cells

BDNF (10 ng/ml) +PDGF (10 ng/ml) 10% Serum bFGF (25 ng/ml)  EGF (20 ng/ml)

T3, bFGF, PDGF + growth factor withdrawal

slide-5
SLIDE 5

Recommended Research Areas

Research approaches

Molecular genomics/proteomics; virus and host

Viral gene regulation in specific cells i.e. glia vs neuron

Immunology of therapies and host response to infection

Drug Discovery

Small molecules for intervention of viral growth once identified; relevant cell model for screen

Vaccines, peptides, VLPs (like papilloma virus)

Prophylactic

Therapeutic

Pre-clinical studies/clinical studies

Relevant animal model for pathogenesis and intervention

5

slide-6
SLIDE 6

Non-Human Primate Model

6

slide-7
SLIDE 7

Recommended Research Areas

Research approaches

Molecular genomics/proteomics; virus and host

Viral gene regulation in specific cells i.e. glia vs neuron

Immunology of therapies and host response to infection

Drug Discovery

Small molecules for intervention of viral growth once identified; relevant cell model for screen

Vaccines, peptides, VLPs (like papilloma virus)

Prophylactic

Therapeutic

Pre-clinical studies/clinical studies

Relevant animal model for pathogenesis and intervention

7

slide-8
SLIDE 8

NIH-Funded JCV/PML Research Areas

Number of Projects Funded Per Major Research Area FY 2008 FY2009 FY2010 Epidemiology/Pathogen esis 2 2 2 Disease/Molecular Mechanisms 8 10 8 Therapeutic/Vaccine Development 2 4 Cellular Response/Structure 2 2 2 Clinical Presentation/Diagnostic s 3 3 3 Immunology/Virology 9 7 5

Data retrieved from the public accessible NIH Report: http://report.nih.gov/ 8

slide-9
SLIDE 9

Comparison of NIH-Funding for JCV & HSV

Data retrieved from the public accessible NIH Report: http://report.nih.gov/ 9

slide-10
SLIDE 10

Summary

To advance research, the field needs more formal support and collaboration and needs infusion of new ideas. Additionally, recruiting new principal investigators from different fields such as rheumatology, immunology, basic neuroscientist (glial) cells, genetics and neuro-infectious diseases will help to advance the science that should inform medical research.

10