Reliable & Timely Mo-99 Supply Globally Mo-99 Topical Meeting - PowerPoint PPT Presentation

Reliable & Timely Mo-99 Supply Globally Mo-99 Topical Meeting Montreal, September 2017 Jayne Senior

Agenda 1. ANM Project Background 2. ANM Design & Capacity 3. ANM Construction & Commissioning Status

ANM Project Background

ANSTO Nuclear Medicine – ANM

ANSTO Nuclear Medicine Operated as a One product- Scalable domestic Full lifecycle subsidiary of Mo-99 and worldwide consideration ANSTO supply

ANSTO Nuclear Medicine Project TWO PARTS Mo-99 Facility Synroc Waste Plant ANM SyMo

OPAL Mo-99 Plant “ANM” Synroc Waste Plant “SyMo” Lucas Heights Location

ANM Design & Capacity

ANSTO Nuclear Medicine Project TWO PARTS Mo-99 Plant Synroc Waste Plant ANM SyMo 3,500 6 day Ci per week Hot Isostatic Press technology LEU fuel & LEU targets 320 cans produced per year Base Digestion process Integrated with Mo-99 facility Proven, reliable technology Treats Intermediate Level Liquid Waste Low emissions (Xe-133) Waste volume reduction by 90% Integrated preparation and testing labs Immobilised waste form

Integrated Mo-99 Production Cycle Plate Target OPAL Irradiation Plate Transport Generator Production Chemical Separation ANM

ANM Mo-99 production process Filtering Plates Dissolution Purification Conditioning Mo-99 Patient and separation Waste streams

World best safety features New Separate hot production State of art hot Radiation cells for each efficiencies cell design shielding process step throughout Best practice Extensive In-cell hot cell emission equipment transfer control back-up system systems

ANM – Capacity and Flexibility World Demand Profile ANM Supply Profile 9000 6-Day Ci 3500 6-Day Ci 90 90 80 80 70 70 60 60 50 50 % Demand % Supply 40 40 30 30 20 20 10 10 0 0 weekend rest of week weekend rest of week

Capacity Increase Timing Projection of 6-Day Ci Production/Week ANM 4000 10 Runs x 12 Plates 3500 Current Facility 3000 5 Runs x 12 Plates 2500 Current Facility 4 Runs x 8 Plates 2000 1500 1000 500 0 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 2016 2017 2018

Construction & Comissioning Status

Before 16

After……

Front Entrance

Ramp to Front Entrance

Side Access

Production Cell Face

Hydrogen Cell face

Dissolution Cell Control Panel

Waste Handling Cells

Rear of Hot Cells

Rear of Hot Cells

Basement Gas Tanks

Basement Iodine Filters

Plant Room

QC Intermediate Sample Test Lab

QC Intermediate Sample Test Lab

Process Preparation Room

Mo-99 Facility Milestones Operation Public Construction Active Commissioning licence consultation complete underway commissioning submission and operation to ARPANSA ACTIVE COMMISSIONING COMMISSIONING Subject to APRIL JUNE JULY November ARPANSA 2017 2017 2017 2017 licence

ANM Commissioning Milestones Instrumentation Design Operational TGA / Product Product Qualification Qualification Qualification ARPANSA Qualification (IQ) Validation (DQ) (OQ) Licences (PQ) Facility Facility Services Services Complete Supply Complete Complete Audits Low & High Customer End Activity Validation October/ Runs Samples Early Finish 18 Start 20 In Cell In Cell November November November Process Process Equipment Equipment Commenced Finish 26 October

Current Operations and ANM Transition Planned Scale up of ANM + Reduction in Current Operations 10 10 9 8 8 Current Facility 7 6 Full Capacity 6 (Now) 5 5 4 4 4 3 Current Facility 3 2 2 Shut-Down 2 (Q3 2018) 1 1 0 0 0 0 + (5) 2 + (4) 4 + (3) 6 + (2) 8 + (1) 10 + (0) Number of runs per week in ANM + (Number of runs per week in B54)

Reliable & Timely Mo-99 Supply Globally Mo-99 Topical Meeting Montreal, September 2017 Jayne Senior