Reliable & Timely Mo-99 Supply Globally Mo-99 Topical Meeting - - PowerPoint PPT Presentation

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Reliable & Timely Mo-99 Supply Globally Mo-99 Topical Meeting - - PowerPoint PPT Presentation

Reliable & Timely Mo-99 Supply Globally Mo-99 Topical Meeting Montreal, September 2017 Jayne Senior Agenda 1. ANM Project Background 2. ANM Design & Capacity 3. ANM Construction & Commissioning Status ANM Project Background ANSTO


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Mo-99 Topical Meeting Montreal, September 2017 Jayne Senior

Reliable & Timely Mo-99 Supply Globally

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Agenda

  • 1. ANM Project Background
  • 2. ANM Design & Capacity
  • 3. ANM Construction & Commissioning Status
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ANM Project Background

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ANSTO Nuclear Medicine – ANM

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ANSTO Nuclear Medicine

Operated as a subsidiary of ANSTO One product- Mo-99 Scalable domestic and worldwide supply Full lifecycle consideration

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Mo-99 Facility

ANM

Synroc Waste Plant

SyMo TWO PARTS

ANSTO Nuclear Medicine Project

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Synroc Waste Plant “SyMo” Mo-99 Plant “ANM” OPAL

Lucas Heights Location

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ANM Design & Capacity

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Mo-99 Plant

ANM

Synroc Waste Plant

SyMo

TWO PARTS

3,500 6 day Ci per week LEU fuel & LEU targets Base Digestion process Proven, reliable technology Low emissions (Xe-133) Integrated preparation and testing labs Hot Isostatic Press technology 320 cans produced per year Integrated with Mo-99 facility Treats Intermediate Level Liquid Waste Waste volume reduction by 90% Immobilised waste form

ANSTO Nuclear Medicine Project

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Integrated Mo-99 Production Cycle

OPAL Irradiation Plate Transport Plate Target Generator Production Chemical Separation ANM

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ANM Mo-99 production process

Plates Dissolution Filtering and separation Purification Conditioning Mo-99 Patient Waste streams

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World best safety features

New production efficiencies throughout State of art hot cell design Separate hot cells for each process step Radiation shielding In-cell equipment back-up Best practice hot cell transfer system Extensive emission control systems

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ANM – Capacity and Flexibility

10 20 30 40 50 60 70 80 90

weekend rest of week

World Demand Profile 9000 6-Day Ci

% Demand

10 20 30 40 50 60 70 80 90

weekend rest of week

ANM Supply Profile 3500 6-Day Ci

% Supply

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Capacity Increase Timing

Projection of 6-Day Ci Production/Week

2016 2017 2018

500 1000 1500 2000 2500 3000 3500 4000 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2

Current Facility 4 Runs x 8 Plates Current Facility 5 Runs x 12 Plates ANM 10 Runs x 12 Plates

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Construction & Comissioning Status

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16

Before

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After……

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Front Entrance

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Ramp to Front Entrance

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Side Access

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Production Cell Face

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Hydrogen Cell face

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Dissolution Cell Control Panel

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Waste Handling Cells

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Rear of Hot Cells

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Rear of Hot Cells

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Basement Gas Tanks

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Basement Iodine Filters

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Plant Room

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QC Intermediate Sample Test Lab

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QC Intermediate Sample Test Lab

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Process Preparation Room

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Mo-99 Facility Milestones

Operation licence submission to ARPANSA Public consultation Construction complete

Commissioning

underway Active commissioning and operation

APRIL 2017 JUNE 2017 JULY 2017 November 2017 Subject to ARPANSA licence

COMMISSIONING

ACTIVE

COMMISSIONING

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ANM Commissioning Milestones

Design Qualification (DQ) TGA / ARPANSA Licences Instrumentation Qualification (IQ)

Low & High Activity Runs Finish 18 November

Product Qualification (PQ)

Facility Services Complete In Cell Process Equipment Finish 26 October

Operational Qualification (OQ)

Audits End October/ Early November Facility Services Complete In Cell Process Equipment Commenced Complete

Product Validation

Supply Customer Validation Samples Start 20 November

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Current Operations and ANM Transition

2 4 6 8 10

5 4 3 2 1

1 2 3 4 5 6 7 8 9 10 0 + (5) 2 + (4) 4 + (3) 6 + (2) 8 + (1) 10 + (0)

Planned Scale up of ANM + Reduction in Current Operations

Number of runs per week in ANM + (Number of runs per week in B54) Current Facility Full Capacity (Now) Current Facility Shut-Down (Q3 2018)

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Mo-99 Topical Meeting Montreal, September 2017 Jayne Senior

Reliable & Timely Mo-99 Supply Globally