Reframing the situation Implementing penalties for frameshifting - PowerPoint PPT Presentation

Sep 05, 2023 •116 likes •197 views

Reframing the situation Implementing penalties for frameshifting mutations in a sequence alignment function Frameshift mutations Esciencecentral.org How do you do it? Movement Score Indel (1) -1 Indel (3) 0 Mismatch 0 Match 1

Reframing the situation Implementing penalties for frameshifting mutations in a sequence alignment function
Frameshift mutations Esciencecentral.org
How do you do it? Movement Score Indel (1) -1 Indel (3) 0 Mismatch 0 Match 1 Match(3) +1
Does it work? Function Alignment Score Global Alignment 6 GCCTGTGACTTA G -C - -TGACTTA Local Alignment 7 TGTGACTTA GCTGACTTA Frame Alignment 14 GCCTGTGACTTA GC - - -TGACTTA
NMDA Receptor Cull-Candy et al. 2004
It works a bit!
Does it work across species?

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