Reframing the situation Implementing penalties for frameshifting - - PowerPoint PPT Presentation

reframing the situation
SMART_READER_LITE
LIVE PREVIEW

Reframing the situation Implementing penalties for frameshifting - - PowerPoint PPT Presentation

Reframing the situation Implementing penalties for frameshifting mutations in a sequence alignment function Frameshift mutations Esciencecentral.org How do you do it? Movement Score Indel (1) -1 Indel (3) 0 Mismatch 0 Match 1


slide-1
SLIDE 1

Reframing the situation

Implementing penalties for frameshifting mutations in a sequence alignment function

slide-2
SLIDE 2

Frameshift mutations

Esciencecentral.org

slide-3
SLIDE 3

How do you do it?

Movement Score Indel (1)

  • 1

Indel (3) Mismatch Match 1 Match(3) +1

slide-4
SLIDE 4

Does it work?

Function Alignment Score Global Alignment

GCCTGTGACTTA G -C - -TGACTTA

6 Local Alignment

TGTGACTTA GCTGACTTA

7 Frame Alignment

GCCTGTGACTTA GC - - -TGACTTA

14

slide-5
SLIDE 5

NMDA Receptor

Cull-Candy et al. 2004

slide-6
SLIDE 6

It works a bit!

slide-7
SLIDE 7

Does it work across species?

slide-8
SLIDE 8