Reframing the situation Implementing penalties for frameshifting - - PowerPoint PPT Presentation

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Sep 05, 2023 116 likes •201 views

Reframing the situation Implementing penalties for frameshifting mutations in a sequence alignment function Frameshift mutations Esciencecentral.org How do you do it? Movement Score Indel (1) -1 Indel (3) 0 Mismatch 0 Match 1

SLIDE 1

Reframing the situation

Implementing penalties for frameshifting mutations in a sequence alignment function

SLIDE 2

Frameshift mutations

Esciencecentral.org

SLIDE 3

How do you do it?

Movement Score Indel (1)

Indel (3) Mismatch Match 1 Match(3) +1

SLIDE 4

Does it work?

Function Alignment Score Global Alignment

GCCTGTGACTTA G -C - -TGACTTA

6 Local Alignment

TGTGACTTA GCTGACTTA

7 Frame Alignment

GCCTGTGACTTA GC - - -TGACTTA

SLIDE 5

NMDA Receptor

Cull-Candy et al. 2004

SLIDE 6

It works a bit!

SLIDE 7

Does it work across species?

SLIDE 8