Power of genetic epidemiology study 28.10.2005 GE02 day 4 part 4 - - PowerPoint PPT Presentation

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Power of genetic epidemiology study 28.10.2005 GE02 day 4 part 4 - - PowerPoint PPT Presentation

Power of genetic epidemiology study 28.10.2005 GE02 day 4 part 4 Yurii Auchenko Erasmus MC Rotterdam Power of the test that p Some anticipated p n | np | 2 + Z Z np ( 1 p ) n + =


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SLIDE 1

Power of genetic epidemiology study

28.10.2005 GE02 day 4 part 4 Yurii Auchenko Erasmus MC Rotterdam

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SLIDE 2

Power of the test that p  ½

  • Some anticipated p

A n – B n = – C (see solution in Normal approximation)

  • For α =0.05 and power = 1 – β = 80%

– Zα = 1.96, Zβ = 0.84

β α

Z Z p np n np + ≥ − − ) 1 ( | 2 | 2 ) 1 ( ) ( n pn n p p Z Z − = − − +

β α

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Other tests

  • P(Mut in cases)  P(Mut in controls), etc.
  • Can be obtained in similar way
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SLIDE 4

Genetic power calculator

http://pngu.mgh.harvard.edu/~purcell/gpc/

GRR(MM) = P(disease|MM)/P(disease|NN) GRR(MN) = P(disease|MN)/P(disease|NN)