Polypharmacy and anticholinergic burden Katherine Le Bosquet - - PowerPoint PPT Presentation

polypharmacy and anticholinergic burden
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Polypharmacy and anticholinergic burden Katherine Le Bosquet - - PowerPoint PPT Presentation

Polypharmacy and anticholinergic burden Katherine Le Bosquet December 2018 3 rd WHO Global Patient Safety Challenge Launched March 2017 WHO Global Patient Safety Challenge Reduce the level of severe, avoidable harm related to


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Katherine Le Bosquet

Polypharmacy and anticholinergic burden

December 2018

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3rd WHO Global Patient Safety Challenge – Launched March 2017

WHO Global Patient Safety Challenge –

Reduce the level of severe, avoidable harm related to medications by 50% over 5 years, globally 3 early priority actions:

  • Polypharmacy
  • High risk situations
  • Transfers of care
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“Patients and the public are not

always medication-wise. They are too often made to be passive recipients of medicines and not informed and empowered to play their part in making the process of medication safer”. “Systems and practice of medication are complex and often dysfunctional, and can be made more resilient to risk and harm if they are well understood and designed”.

“Health care professionals sometimes

prescribe and administer medicines in ways and circumstances that increase the risk of harm to patients”

"Medicines are sometimes complex

and can be puzzling in their names, or packaging and sometimes lack sufficient or clear information. Confusing ‘lookalike sound alike’ medicines names and/or labelling and packaging are frequent sources of error and medication-related harm that can be addressed."

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Medicines Safety Programme and Medicines value Programme

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For the NHS to meet the needs of future patients in a sustainable way, we need to close three gaps:

Radical upgrade in prevention

Health and wellbeing gap

New Care Models and new support

Care and quality gap

Efficiency and investment

Funding and efficiency gap

Achieving the NHS Five Year Forward View (2014-19)

Developed by the Care Quality Commission, Public Health England and NHS Improvement with the involvement of patient groups, clinicians and independent experts

Medicines are an important part of NHS care and help many people to get well

However, quality, safety and increasing costs continue to be issues…

  • Around 5-8% of hospital

admissions are medicines related, many preventable

  • Bacteria are becoming resistant to

antibiotics through overuse which is a global issue

  • Up to 50% of patients don’t take

their medicines as intended, meaning their health is affected

  • Use of multiple medicines is

increasing – over 1 million people now take 8 or more medicines a day, many of whom are older people

We spend £18.2 billion a year on medicines (£1 in every £7 that the NHS spends) and they are a major part of the UK economy

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Due to people living longer, more complex and innovative medicines being developed, and more specialist medicines being used

There is growing pressure on the NHS drugs bill

5,000 10,000 15,000 20,000 Gross spend £m Primary care Hospital & community health sector Total

Medicines costs at list price (excl. VAT) before any discounts

  • Overall medicines

spend 2016/17 was £17.4bn, an increase of 33.7% from £13bn in 2010/11.

  • 2017/18 Overall spend

was £18.2bn.

  • Cost of medicines

prescribed and dispensed in primary care rose from £8.6bn in 2010/11 to £9.0bn in 2016/17, a rise of 3.6%

  • Cost of medicines used

in hospitals increased from £4.2bn in 2010/11 to £8.3bn in 2016/17, a rise of 98.3%

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The Medicines Value Programme has been set up to respond to these challenges

The NHS wants to help people to get the best results from their medicines – while achieving best value for the taxpayer

Savings will be reinvested in improving patient care and providing new treatments to grow the NHS for the future

The NHS policy framework that governs access to and pricing of medicines

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The commercial arrangements that influence price

2

Optimising the use of medicines

3

Developing the infrastructure to support an efficient supply chain

4

A whole system approach….

  • NHS England, NHS

Improvement, NHS Digital, Health Education England

  • Regional offices link with STPs,

ICSs, CCGs, and providers

  • Nationally coordinated with

AHSNs, Getting It Right First Time, NHS Right Care and NHSCC

Following the Next Steps on the NHS Five Year Forward View and Carter Report

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www.england.nhs.uk

Four Regional Medicines Optimisation Committees (RMOCs), chaired by regional medical directors and supported by regional pharmacists Connecting CCGs and providers to take coordinated action Initial priorities:

  • Biosimilars
  • Generics
  • Polypharmacy
  • Effective prescribing in

primary care

  • Patient safety

Optimising the use of medicines

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www.england.nhs.uk

  • 1. Patients

Medicines Safety Programme

  • Improved shared decision making, including when to

stop medication

  • Improve information for patients and families, and

access to inpatient medication information

  • Encourage and support patients and families to raise

any concerns about their medication

Set up following the recommendations of the Short Life Working Group

  • Improved shared care between health and care professionals
  • Training in safe and effective medicines use is embedded in

undergraduate training

  • Reporting and learning from medication errors
  • Repository of good practice to share learning
  • New defences for pharmacists if they make accidental

medication errors

  • The accelerated roll-out of hospital e-prescribing and medicines

administration systems

  • The roll-out of proven interventions in primary care such as

PINCER

  • The development of a prioritised and comprehensive suite of

metrics

  • New systems linking prescribing data in primary care to hospital

admissions

  • New research on medication error to be encouraged
  • 2. Medicines
  • Increase awareness of ‘look alike sound alike’ drugs

and develop solutions to prevent these being introduced

  • Patient friendly packaging and labelling
  • Ensure that labelling contributes to safer use of

medicines

  • 3. Healthcare professionals
  • 4. Systems and practice
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www.england.nhs.uk

The burden of medication errors

Medication errors can include prescribing, dispensing, administration and monitoring errors. Medication error can result in adverse drug reactions, drug-drug interactions, lack of efficacy, suboptimal patient adherence and poor quality of life and patient experience An estimated 237 million medication errors occur in the NHS in England every year 68.3 million errors (28% of total) cause moderate or serious harm The estimated NHS costs of definitely avoidable ADRs are £98.5 million per year, consuming 181,626 bed-days, causing 712 deaths, and contributing to 1,708 deaths

EEPRU report - PREVALENCE AND ECONOMIC BURDEN OF MEDICATION ERRORS IN THE NHS IN ENGLAND November 2017*

WHO Global Patient Safety Challenge – Reduce the level of severe, avoidable harm

related to medications by 50% over 5 years, globally 3 early priority actions: polypharmacy, high risk situations, transfers of care

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www.england.nhs.uk

Polypharmacy

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www.england.nhs.uk

Appropriate polypharmacy: 'Prescribing for an individual for complex conditions or for multiple conditions in circumstances where medicines use has been optimised and where the medicines are prescribed according to best evidence.’ Problematic polypharmacy: 'The prescribing of multiple medicines inappropriately, or where the intended benefit of the medicines are not realised.’ When risks of medications outweighs the benefits for the patient

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www.england.nhs.uk

Causes of Polypharmacy

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  • Multiple morbidities
  • Poor communication between healthcare teams
  • Increased longevity
  • Advancements in drug therapy and preventative

strategies

  •  Accessibility to medicines e.g. non prescription drugs
  • Prescribing cascade
  • Guidance and targets e.g. QOF, NICE quality

standards

  • Multiple prescribers and pathways
  • Poor medicines reconciliation and medication review
  • Mistaking ageing for disease/inappropriate response to

non-medical problems

  • A “pill for every ill” and psychosocial

issues

  • Patient, staff and carer demand
  • Target driven therapeutic enthusiasm

and unrealistic expectations

  • Failure to individualise treatments

and set clear therapeutic goals

  • Poor evidence base for prescribing

drugs in older people

  • Reluctance to discontinue drugs
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www.england.nhs.uk

Increased risks from Polypharmacy

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  • Increase risk of ADR’s
  • Increased risk of interactions
  • >10 medication increases your risk of hospital admission by 300%
  • Complex regimes are increasingly confusing for patients
  • Poor compliance (30-50% of medicine for LTC not taken as intended)
  • Increase pill burden
  • Increase carer burden and healthcare time take for administering

medication and clerking

  • Increased risk at transfer of care
  • Increased Anticholinergic burden
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www.england.nhs.uk

Polypharmacy

‘Problematic polypharmacy’ - prescribing of multiple medicines inappropriately, or where the intended benefit is not realised

  • Average no. of prescription

items per head in 2016 was 20, compared to 14.8 in 2006

  • De-prescribing medicines

in a controlled way reduces the risk of medicines related complications and this requires clinical medicines reviews

  • NHS England’s care home

vanguards have reduced these risks and the NHS is rolling out the Enhanced Health in Care Homes Framework and developing a medicines optimisation in care homes scheme October 2017 data: patients prescribed 10 or more unique medicines

  • 5.15% of ALL patients
  • 8.19% (aged 65 and over); 9.76% (aged 75 and over); 10.46% (aged 85 and over)
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NHS BSA Polypharmacy Metrics via ePACT2 – July 2017

https://www.nhsbsa.nhs.uk/sites/default/files/2018-02/PolyPharmacy%20Specification%20v1%200%20July%202017_0.pdf Accessed 05/12/2018