Physical activity and breast cancer: mechanisms and interventions ? - - PowerPoint PPT Presentation

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Physical activity and breast cancer: mechanisms and interventions ? - - PowerPoint PPT Presentation

Dec 05, 2023 230 likes •351 views

Physical activity and breast cancer: mechanisms and interventions ? Kristin Campbell, BSc. PT, PhD University of British Columbia, Vancouver, Canada Kristin.campbell@ubc.ca @cepl_ubc www.cepl.rehab.med.ubc.ca PA#and#Preven*on:#Epidemiology #

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Physical activity and breast cancer: mechanisms and interventions?

Kristin Campbell, BSc. PT, PhD University of British Columbia, Vancouver, Canada Kristin.campbell@ubc.ca @cepl_ubc www.cepl.rehab.med.ubc.ca

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PA#and#Preven*on:#Epidemiology #

  • 25%#risk#reduc*on#

with#highest#vs.# lowest#levels#of# physical#ac*vity#

  • Greatest#reduc*on#

with#recrea*onal# physical#ac*vity# #

Friedenreich CM. Recent Results in Cancer Research 2011; 188:125-39

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Breast#Cancer#Preven*on#Interven*ons #

Study&

Loca+on& N&

Physical&Ac+vity& Sex& hormones&

Physical& Ac+vity&and& Total&Health& (PI:&McTiernan)& Can&Res&2003& USA& 173& Aerobic& Supervised&&&HomeKbased& 225&min/wk& K4.4%&estradiol&& K1.8%!estrone& Both&NS& & ALPHA&& (PI:& Friedenreich)& JCO&2010& Canada& 320& Aerobic& Supervised&&&HomeKbased& 225&min/wk& K14%&estradiol&& (sig.)& K6.4%&estrone& (NS)& SHAPE& (PI:&& Monninkhof)& JCO&2009& UK& 189& Combined&aerobic&&& resistance&& Supervised&&&HomeKbased&& 150&min/week& No&change& estrogens&

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Infrastructure#to#conduct#human# trials##

Behavioural Medicine Lab; University of Alberta, PI: K. Courneya

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Breast#Cancer#and#Exercise#Trial# in#Alberta #

Recruit 400 postmenopausal healthy women 50-74 years Randomize High volume exercise group

(5 days/wk x 60 mins/session @ 70-80% max HRR)

Moderate volume exercise group

(5 days/wk x 30 mins/session @ 70-80% max HRR)

Compare high vs. moderate exercise groups on endogenous sex hormones, obesity and inflammatory markers, insulin, glucose Follow-up at 24 months: examine exercise maintenance and long term effect on biomarkers PI: Friedenreich Funded by: ACF & CCSRI Slide courtesy of C. Friedenreich

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Alberta#Moving#Beyond#Breast# (AMBER)#Cohort#Study # #

– Team#Leaders:##K.#Courneya#and#C.# Friedenreich# – Funded:##CIHR#Team#Grant# – 1500#women#with#diagnosis#of#stage#IRIIIc# breast#cancer#

  • SelfRreport#and#objec*ve#physical#ac*vity#
  • Maximal#aerobic#fitness#and#strength#
  • Body#composi*on##

– Baseline,#1,#3,#and#5#years#(with#disease#

  • utcomes#at#5R10#years)#

Slide courtesy of K. Courneya

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Integra*on#of#PA#Research#into# Clinical#Trials#Group#CO.21# #

Slide courtesy Kerry Courneya Individuals diagnosed with Stage II or III colon cancer Baseline testing: Including exercise test Randomize Physical Activity Intervention + General Health Education Materials (Intervention) General Health Education Materials (Control) Assessment of disease-free survival at 3 years

  • up to 10 year follow up
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Next#Genera*on#of#Researchers# #

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Exercise#versus#Weight#loss? #

PI:#Anne#McTiernan

#

Campbell et al. J Clin Oncol 2012; 30:2314-2326

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Physical#ac*vity#and#preven*on: # Con*nued#momentum#in#Canada #

  • CCS#UBC#Cancer#Preven*on#Centre#
  • Canadian#Breast#Cancer#Founda*on#2020#

Report#

– Preven*on#one#of#5#key#areas# #

  • New#funding#opportuni*es##