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Physical activity and breast cancer: mechanisms and interventions ? - PowerPoint PPT Presentation

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Physical activity and breast cancer: mechanisms and interventions ? Kristin Campbell, BSc. PT, PhD University of British Columbia, Vancouver, Canada Kristin.campbell@ubc.ca @cepl_ubc www.cepl.rehab.med.ubc.ca PA#and#Preven*on:#Epidemiology #

  1. Physical activity and breast cancer: mechanisms and interventions ? Kristin Campbell, BSc. PT, PhD University of British Columbia, Vancouver, Canada Kristin.campbell@ubc.ca @cepl_ubc www.cepl.rehab.med.ubc.ca

  2. PA#and#Preven*on:#Epidemiology # • 25%#risk#reduc*on# with#highest#vs.# lowest#levels#of# physical#ac*vity# • Greatest#reduc*on# with#recrea*onal# physical#ac*vity# Friedenreich CM. Recent Results in Cancer Research 2011; 188:125-39 #

  3. Breast#Cancer#Preven*on#Interven*ons # Loca+on& N& Study& Physical&Ac+vity& Sex& hormones& Physical& USA& 173& Aerobic& K4.4%&estradiol&& Ac+vity&and& Supervised&&&HomeKbased& K1.8% ! estrone& Total&Health& 225&min/wk& Both&NS& (PI:&McTiernan)& & Can&Res&2003& ALPHA&& Canada& 320& Aerobic& K14%&estradiol&& (PI:& Supervised&&&HomeKbased& (sig.)& Friedenreich)& 225&min/wk& K6.4%&estrone& JCO&2010& (NS)& SHAPE& UK& 189& Combined&aerobic&&& No&change& (PI:&& resistance&& estrogens& Monninkhof)& Supervised&&&HomeKbased&& JCO&2009& 150&min/week&

  4. Infrastructure#to#conduct#human# trials## Behavioural Medicine Lab; University of Alberta, PI: K. Courneya

  5. Breast#Cancer#and#Exercise#Trial# in#Alberta # Recruit 400 postmenopausal PI: Friedenreich healthy women 50-74 years Funded by: ACF & CCSRI Randomize High volume exercise group Moderate volume exercise group (5 days/wk x 60 mins/session @ (5 days/wk x 30 mins/session @ 70-80% 70-80% max HRR) max HRR) Compare high vs. moderate exercise groups on endogenous sex hormones, obesity and inflammatory markers, insulin, glucose Follow-up at 24 months: examine exercise maintenance and long term effect on biomarkers Slide courtesy of C. Friedenreich

  6. Alberta#Moving#Beyond#Breast# (AMBER)#Cohort#Study # # – Team#Leaders:##K.#Courneya#and#C.# Friedenreich# – Funded:##CIHR#Team#Grant# – 1500#women#with#diagnosis#of#stage#IRIIIc# breast#cancer# • SelfRreport#and#objec*ve#physical#ac*vity# • Maximal#aerobic#fitness#and#strength# • Body#composi*on## – Baseline,#1,#3,#and#5#years#(with#disease# outcomes#at#5R10#years)# Slide courtesy of K. Courneya

  7. Integra*on#of#PA#Research#into# Clinical#Trials#Group#CO.21# # Individuals diagnosed with Stage II or III colon cancer Baseline testing: Including exercise test Randomize Physical Activity Intervention + General Health Education Materials General Health Education (Control) Materials (Intervention) Assessment of disease-free survival at 3 years - up to 10 year follow up Slide courtesy Kerry Courneya

  8. Next#Genera*on#of#Researchers# #

  9. Exercise#versus#Weight#loss? # # PI:#Anne#McTiernan Campbell et al. J Clin Oncol 2012; 30:2314-2326

  10. Physical#ac*vity#and#preven*on: # Con*nued#momentum#in#Canada # • CCS#UBC#Cancer#Preven*on#Centre# • Canadian#Breast#Cancer#Founda*on#2020# Report# – Preven*on#one#of#5#key#areas# # • New#funding#opportuni*es##

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