PEDIATRIC ABDOMINAL CASE STUDIES Julie McKee, RN, MN, CPNP - - PDF document

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PEDIATRIC ABDOMINAL CASE STUDIES Julie McKee, RN, MN, CPNP - - PDF document

9/26/2016 PEDIATRIC ABDOMINAL CASE STUDIES Julie McKee, RN, MN, CPNP DISCLOSURES: NONE OBJECTIVES 1. Identify patients that need referral to pediatric surgery and urgency of that referral. 2. Discuss clinical considerations in the use of


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9/26/2016 1

PEDIATRIC ABDOMINAL CASE STUDIES

Julie McKee, RN, MN, CPNP

DISCLOSURES: NONE OBJECTIVES

 1. Identify patients that need referral to pediatric surgery and urgency of that referral.  2. Discuss clinical considerations in the use of diagnostic evaluation in pediatric patient with abdominal pain.  3. Identify abnormal stooling pattern in pediatric patients and discuss initial evaluation and management.

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9/26/2016 2 CASE STUDY #1

 14 year old female with acute onset lower abdominal pain  No fevers, nausea, vomiting or diarrhea  No urinary symptoms  Normal stooling pattern  No ill contacts

HISTORY

 PMH: ovarian teratoma  PSH: right oopherectomy

PHYSICAL EXAM

 General: No acute distress  Abdomen: soft, nondistended, tender in bilateral lower quadrants, no palpable masses

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9/26/2016 3 DIAGNOSTICS DIAGNOSTICS TUMOR MARKER LABS

 AFP, HCG quantitative tumor antigen  LH, FSH  Inhibin A, Inhibin B  CEA, CA 19‐9, CA 125  Anti mullerian hormone

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9/26/2016 4

OVARIAN TERATOMA, HEMORRHAGIC CYST, FOLLICULAR CYST OVARIAN TORSION

 Ultrasound used to determine size of mass, characteristics: solid vs cyst, blood flow to the ovaries  MRI used to evaluate this further in complex patient as ours  Tumor markers: normal results for our case study  Simple cysts less than 5 cm can be watched and surveilled with

  • US. Most are follicular cysts. Cysts with few internal septations

can be observed with repeat imaging, most are hemorrhagic cysts.  Solid components need further evaluation with surgeon  Torsion is an emergent condition as the ovary can be salvaged

QUESTIONS CASE STUDY #2

 8 yr old female with 1 day abdominal pain  Started periumbilical area, worsened with time  Decreased appetite, no nausea or vomiting  One loose stool  No urinary symptoms  No ill contacts  In ER, pain now in RLQ, low grade fever  No PMH/PSH – otherwise healthy

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9/26/2016 5 PHYSICAL EXAM

 Tenderness focally in right lower quadrant  Abdomen otherwise soft, nondistended, no masses  No other pertinent findings on physical exam

CASE STUDY #2

 Labs:  WBC 16.1; 81% neutrophils  Electrolytes normal

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9/26/2016 6 PAIN VS TENDERNESS DIFFERENTIAL

 Female: ovarian pathology, endometriosis  Urinary tract  Gastrointestinal (IBD,constipation)  Pneumonia, strep throat

APPENDICITIS

Abdominal pain caused by distended appendix, pain usually comes first in history, followed by +/‐ nausea, vomiting, anorexia, fever, pain is constant

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9/26/2016 7 PHYSICAL EXAM

 Obturator sign‐ pain with internal rotation of leg  Rovsing sign – rebound tenderness at RLQ site after pushing and releasing LLQ  Psoas sign– pain with raising leg against resistance  Pain should be constant, worse with palpation/percussion to RLQ  Distraction good technique with pediatric patient

US FINDINGS

 Noncompressible  Size  Surrounding tissue  Tenderness with exam  Fluid collection  Free fluid vs loculated fluid

DIAGNOSTIC ACCURACY

 In study using maximal outer diameter of greater than or equal to 7 mm for the appendix, US compared favorably to CT  This saves patient radiation exposure, lower cost  If CT scan warranted, dose reduction of radiation strategies should be implemented.  If your local imaging is not regularly doing pediatric US, clinical suspicion is high, refer  If you are considering CT scan, refer  Children are more sensitive to the radiation, have longer life expectancy to manifest late effect cancer

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9/26/2016 8 MANAGEMENT

 OR for laparoscopic appendectomy  Preoperative considerations:  Hydration, antibiotics

ACUTE PERFORATED APPENDICITIS MANAGEMENT

 Antibiotic treatment with inteval appendectomy 6‐8 weeks later vs operation  Limited CT scan to determine well formed abscess  If intraabdominal abscess, abdominal pain > 3 days duration, upfront antibiotics, IR drain if possible and interval appendectomy 8 weeks later

ACUTE PERFORATED APPENDICITIS TREATMENT PROTOCOL

 Observational study of pediatric patients with suspected acute perforated appendicitis at Miami Children’s Hospital  Less than 96 hours of symptoms, WBC >12,000, diagnostic imaging findings  Exclusions: symptoms > 96 hours, palpable mass on exam, or well formed abscess seen on imaging  Zosyn, PICC, minimum 7 day course  Discontinuation of abx: afebrile > 48, normal WBC, absence of tenderness (fever = >100)  18 month study, 751 patients

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9/26/2016 9 STUDY DISCUSSION

 More likely to be ruptured: younger age, pain longer than 3 days, generalized tenderness, fever over 38 degrees celsius.  Lower complication rates, fewer abscesses, trend toward shorter LOS  Treatment failure predictors: WBC> 15,000, especially when accompanied by fecalith, symptoms > 48 hours  Other studies: prolonged fever, higher band count, imaging findings of disease spread beyond RLQ

OUR TREATMENT PROTOCOL PERFORATED APPENDICITIS

 Ceftriaxone, flagyl once daily IV dose  Discharge criteria: home once afebrile (<38) for 48 consecutive hours, eating, pain controlled, ambulating, no diarrhea, normalized white blood cell count

NONVISUALIZED APPENDIX

 This can present a diagnostic challenge. If you are clinically suspicious of appendicitis, refer.  Ensure close follow up if imaging/labs reassuring – can be done with PCP

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9/26/2016 10 RED FLAGS

 When evaluating children with vague abdominal pain, differential is broad, few things to consider:  Weight loss  Severe vomiting  Chronic severe diarrhea  GI bleeding  Hematemesis  Family history of inflammatory bowel disease  Appropriate referral may be to start with pediatric GI

QUESTIONS CASE STUDY #3

 8 week old female  Nonbilious vomiting after every feed for 2 weeks, increased fussiness  Passing flatus, no bowel movement x 2 days  Decreased urine output

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9/26/2016 11 PHYSICAL EXAM LABS

  • NA

135

  • K

3.7

  • CL

91* (low)

  • CO2

34* (high)

  • BUN

13

  • CREATININE

0.24*

  • GLUCOSE

105*

  • CALCIUM

10.8

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9/26/2016 12 US FINDINGS

 Size criteria – based on age, 4 mm x 14 mm (width x length)  GI tract content not moving through pylorus  UGI can suggest pyloric stenosis, but gold standard test is ultrasound with size criteria

DIFFERENTIAL

 Bilious vomiting – must be evaluated for malrotation immediately  Reflux  Classic lab findings: metabolic alkalosis

PYLORIC STENOSIS

 Thickened and elongated pylorus that acts like an obstruction  Pylorus is smooth muscle at end of stomach Firstborn, more common in male

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9/26/2016 13 MANAGEMENT

 OR for pyloromyotomy  Preoperative considerations: fluid resuscitation, electrolyte correction will happen with fluid resuscitation, NPO  Study based fluid needs and LOS on chloride level at diagnosis. For chloride <97: 2 x 20m/kg NS bolus, recheck labs to expedite care, decrease cost  Early diagnosis= less electrolyte derangement and shorter LOS

QUESTIONS CASE STUDY #4

 9 mos old male with abdominal pain, emesis and bloody stool  One week prior had been to ER for poor feeding and emesis  No PMH/PSH

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9/26/2016 14 LABS

  • WBC 7
  • HCT 31.5
  • Plt 449
  • Na 138
  • K 4.2
  • Cl 99
  • Co2 22
  • BUN .2
  • Creat 0.2
  • Glucose 90

ULTRASOUND INTUSSUSCEPTION

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9/26/2016 15 DECISION MAKING

 Differential  ileocolic vs small bowel‐small bowel intussusception  Other historical information  Other diagnostics  Concern for intussusception : notification of pediatric surgery team, radiologic reduction can happen elsewhere, be prepared to transfer, require IV access at our institution. Risk of perforation during exam.  Small bowel‐small bowel often resolves, does not require urgent referral

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9/26/2016 16 DIFFERENTIAL

 Classic presentation: age range 6 months‐ 6 years, preceeded by viral illness symptoms, crampy abdominal pain – Ileocolic  Small bowel to small bowel can happen intermittently and usually does not require surgery  Older children, consider pathologic mass as a lead point – lymphoma

MANAGEMENT

 Fluid resuscitation  Enema reduction – if successful, observation for recurrence  74‐79% success rate  If unsuccessful, delayed repeat enema vs operative reduction  Retrospective review over 5 year period: of the unsuccessful enema reduction group, ¾ went to surgery, ¼ had delayed repeat enema. 64% of delayed repeat enema did not need surgery  Bowel resection occurred more often with immediate surgery group

QUESTIONS

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9/26/2016 17 CASE STUDY #5

 6 week old male  Term, passed meconium at hour #29, after rectal stimulation  Required suppositories and rectal stimulation for ongoing constipation  Poor weight gain, emesis

CASE STUDY #5

 Mild distention on exam, slightly fussy, nontender  Electrolytes unremarkable  Xray‐ first line of diagnostic evaluation after history and physical.

CASE STUDY #5

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9/26/2016 18 DIFFERENTIAL

 Distal bowel obstruction  Rectal exam – patent anus?  Rush of air and stool on exam…

DECISION MAKING

 Infants should pass first meconium in first 24 hours of life  Stooling patterns in infancy can vary widely  Refer to pediatric surgery, we often will order contrast enema  Keep child stooling until they can be seen – glycerin suppositories

CASE STUDY #5

 Suction rectal biopsy  Path: Suction rectal biopsy: ‐ Ganglion cells (presence/absence): ABSENT; No ganglion cells present. ‐ Nerve Trunk Hypertrophy (presence/absence): PRESENT ‐ Calretinin Stain Result: NEGATIVE

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9/26/2016 19 HIRSCHSPRUNGS

 Aganglionic intestine can only contract  Peristalsis requires contraction and relaxation to have bowel movement

MANAGEMENT

 Rectal irrigations with warm saline, 20 ml/kg with soft red rubber tube  Parents can be taught to do at home  Surgical intervention – colostomy – 2 stage procdure  Pull through as 1 stage to remove aganglionic bowel

LONG TERM CONSIDERATIONS

 Enterocolitis  Bowel management

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9/26/2016 20 QUESTIONS

CONSTIPATION

Evidence based guidelines from North American Society for Pediatric Gastroenterology, Heptalogy, and Nutrition (NASPGHAN) and European Society for Pediatric Gastroenterology, Heptalogy and Nutrition(ESPGHAN)

QUESTION 1: WHAT IS THE DEFINITION OF FUNCTIONAL CONSTIPATION?

 Rome III diagnostic criteria  In the absence of pathology, 2 or more of the following for child <4 years of developmental age for at least 1 month  less than or = 2 defecations a week  1 episode of incontinence per week  History of excessive stool retention  History of painful or hard BM  Presence of large fecal mass in rectum  History of large diameter stools  Accompanying symptoms may include irritability, decreased appetite, and or early satiety, which may disappear immediately following passage of a large stool

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9/26/2016 21 ROME III DIAGNOSTIC CRITERIA FOR FUNCTIONAL CONSTIPATION

 For children with developmental age >4 with insufficient criteria for IBS, have to have criteria fulfilled at least once per week for at least 2 months before diagnosis:  less than or = 2 defecations a week  1 episode of incontinence per week  History of retentive posturing or excessive volitional stool retention  History of painful or hard BM  Presence of large fecal mass in the rectum  History of large diameter stool

ALARM SIGNS AND SYMPTOMS

 Constipation starting early < 1 month of age  Delayed passage of meconium > 48 hours of life  Family history of Hirschsprungs disease  Failure to thrive  Bilious vomiting  Severe abdominal distention  Abnormal position of anus/ perianal fistula  Decreased lower extremity strength/tone/reflex  REFERRAL

HISTORY

 Key to guide your evaluation  Onset, precipitating factors, passage of meconium  Family history  Psychosocial history  Growth curve  Toilet training history

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9/26/2016 22 PHYSICAL EXAM

 General health  Abdominal exam  Perianal exam  DRE – if you suspect HD, not needed if you suspect functional constipation  Xray‐ not needed to diagnose functional constipation

MEDICATIONS

Medication Dosage Osmotic laxatives: Lactulose 1‐2 g/kg once or twice daily PEG 3350 Maintenance 0.2‐0.8 g/kg/day MOM Age dependent: 0.4‐4.8 g/kg/day Stimulant laxative Bisacodyl 5‐10 mg/day Senna 2.5‐20 mg/day Rectal laxative Bisacodyl 5‐10 mg/day NaCl 6 ml/kg once or twice daily Mineral oil 30‐150 ml once daily

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9/26/2016 23 QUESTIONS PEDIATRIC SURGERY RESOURCES

 OHSU and Legacy  503.494.4799  503.413.4300  APSNA – American Pediatric Surgical Nurses Association, Inc.  Apsna.org – access to patient education handouts in English and Spanish  Email: mckeej@ohsu.edu

REFERENCES

 Ashcraft, K. W., Holcomb, G. W., Murphy, J. P., & Ostlie, D. J. (2010). Ashcraft's pediatric surgery (5th ed.). Philadelphia: Saunders/Elsevier.  Dalton, B. G., Gonzalez, K. W., Boda, S. R., Thomas, P. G., Sherman, A. K., & Peter, S. D. (2016). Optimizing fluid resuscitation in hypertrophic pyloric

  • stenosis. Journal of Pediatric Surgery. doi:10.1016/j.jpedsurg.2016.01.013

 Goldin, A.B., Khanna, P., Thapa, M., McBroom, J.A., Garrison, M.M., Parisi, M.T. (2011). Revised criteria for appendicitis in children improve diagnostic

  • accuracy. Pediatric Radiology. 41:993‐999.

 Green, M. (1998). Pediatric diagnosis: Interpretation of symptoms and signs in children and adolescents (6th ed.). Philadelphia: Saunders.  Lautz, T. B., Thurm, C. W., & Rothstein, D. H. (2015). Delayed repeat enemas are safe and cost‐effective in the management of pediatric intussusception. Journal of Pediatric Surgery, 50(3), 423‐427. doi:10.1016/j.jpedsurg.2014.09.002

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9/26/2016 24 REFERENCES

 Miglioretti, D. L., Johnson, E., Williams, A., Greenlee, R. T., Weinmann, S., Solberg, L. I., Smith‐Bindman, R. (2013). The Use of Computed Tomography in Pediatrics and the Associated Radiation Exposure and Estimated Cancer Risk. JAMA Pediatrics JAMA Pediatr, 167(8), 700. doi:10.1001/jamapediatrics.2013.311  Nazarey, P. P., Stylianos, S., Velis, E., Triana, J., Diana‐Zerpa, J., Pasaron, R., Burnweit, C. (2014). Treatment of suspected acute perforated appendicitis with antibiotics and interval appendectomy. Journal of Pediatric Surgery, 49(3), 447‐

  • 450. doi:10.1016/j.jpedsurg.2013.10.001

 Olson, A. D., Hernandez, R., & Hirschl, R. B. (1998). The role of ultrasonography in the diagnosis of pyloric stenosis: A decision analysis. Journal of Pediatric Surgery, 33(5), 676‐681. doi:10.1016/s0022‐3468(98)90186‐5  Smith, J., & Fox, S. M. (2016). Pediatric Abdominal Pain. Emergency Medicine Clinics of North America, 34(2), 341‐361. doi:10.1016/j.emc.2015.12.010

REFERENCES

 Tabbers, M., Dilorenzo, C., Berger, M., Faure, C., Langendam, M., Nurko, S., Benninga,

  • M. (2014). Evaluation and Treatment of Functional Constipation in Infants and Children.

Journal of Pediatric Gastroenterology and Nutrition, 58(2), 265‐281. doi:10.1097/mpg.0000000000000266