Patient-Reported Quality of Life in Prostate Cancer Patients Treated - - PowerPoint PPT Presentation

Patient-Reported Quality of Life in Prostate Cancer Patients Treated With 3D Conformal, Intensity-Modulated or Proton Beam Radiotherapy

Phillip J. Gray, Jonathan J. Paly, Beow Y. Yeap, Martin G. Sanda, James A. Talcott, Howard M. Sandler, Jeff M. Michalski, Daniel A. Hamstra, Justin E. Bekelman and Jason A. Efstathiou

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% 2000 2001 2002 2003 2004 2005 2006 2007 2008

IMRT 3-D CRT

Utilization of IMRT: SEER Data

Percent of Radiotherapy for Prostate Cancer

Bekelman, Mitra, Efstathiou, et al., IJROBP 2011; Sheets, Goldin, Meyer, et al., JAMA 2012

Proton center in operation Proton center under construction Proton center in development

US Proton Therapy Centers

Bowel/Rectal Domain Follow-up (months) 3 12 24 Absolute Instrument Score 60 70 80 90 100 Bowel/Rectal Domain Follow-up (months) 2 6 12 24 Absolute Instrument Score 60 70 80 90 100 Bowel/Rectal Domain Follow-up (months) 3 12 24 Absolute Instrument Score 60 70 80 90 100

3-D CRT Proton Beam IMRT

* * * * * * * *

Patient Reported Bowel Toxicity

* *: Clinically meaningful change

Urinary Irritation/Obstruction Domain Follow-up (months) 3 12 24 Absolute Instrument Score 60 70 80 90 100 Urinary Irritation/Obstruction Domain Follow-up (months) 2 6 12 24 Absolute Instrument Score 60 70 80 90 100 Urinary Irritation/Obstruction Domain Follow-up (months) 3 12 24 Absolute Instrument Score 60 70 80 90 100

3-D CRT Proton Beam IMRT

* *

Patient Reported Urinary Toxicity

*: Clinically meaningful change

N=350 Low- Intermediate Risk Prostate Cancer

R A N D O M I Z E

Proton Beam IMRT 79.2 Gy (RBE) 79.2 Gy Patient-Reported Quality of Life Cost-Effectiveness Physics/Biology

ENDPOINTS

clinicaltrials.gov identifier: NCT01617161