Outline Primary vs. secondary symptoms Mood vs. affect Panic - - PDF document

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Outline Primary vs. secondary symptoms Mood vs. affect Panic - - PDF document

Outline Primary vs. secondary symptoms Mood vs. affect Panic attack vs. panic disorder Acute Stress Disorder/PTSD Mood disorders: major depression and dysthymia Mood disorder treatment: CBT, IPT, and Recovery/empowerment


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Outline

 Primary vs. secondary symptoms  Mood vs. affect  Panic attack vs. panic disorder  Acute Stress Disorder/PTSD  Mood disorders: major depression and

dysthymia

 Mood disorder treatment: CBT, IPT, and

Recovery/empowerment model

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Mood Disorders

 Major Depressive Episode  Major Depressive Disorder  Dysthymic Disorder  “Double Depression”

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Mood vs. Affect

Mood

 A pervasive and

sustained emotion that, in the extreme, colors the person’s perception of the world Affect

 A pattern of observable

behaviors that is the expression of a subjectively experienced state (emotion)

 Variable over time, in

response to changing emotional states (vs. mood, which is pervasive and sustained

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DSM Classification

Major depressive episode

Depressed mood or loss of interest or pleasure

Manic

Persistently elevated, expansive, irritable mood

Mixed

Manic and depressive symptomology

Hypomanic

Similar to manic, not as severe

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Major Depressive Episode

Depressed or irritable mood Loss of interest or pleasure [anhedonia] Weight changes Sleep problems [DFA, SCD, EMA] Motor agitation or retardation Loss of energy Feeling worthless or guilty Poor concentration Thoughts of death or suicide 5 of 9 symptoms for 2+ weeks Problems must cause impairment

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Major Depressive Disorder

 Primary Symptoms (9 MDE symptoms from

previous slide)

 Secondary symptoms: social withdrawal,

temper tantrums, poor schoolwork, poor peer relations, alcohol and substance use

 Onset: age 5-19  Course: Variable; 26% to 70% have

multiple MDE episodes within 5 years

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Major Depressive Disorder

 Duration: median duration = 8 months for

clinical samples [but for >1 yr for a majority of youth]; 1-2 months for community samples

 Prevalence:

 Children: 2%  Adolescents: 4-8%

 Severity and duration: differential for MDD

  • vs. dysthymic disorder
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Mood Descriptors

 Euthymic – normal mood state  Dysphoric – unpleasant mood (e.g., depression, anxiety,

irritability)

 Elevated – more cheerful than normal; not necessarily

indicative of psychopathology

 Euphoric – exaggerated sense of well-being; implies a

pathological mood state (e.g., “up in the clouds”, “flying high”)

 Expansive – lack of restraint in expressing one’s feelings,

frequently with an overvaluation of one’s significance or importance

  • May be accompanied by elevated or euphoric mood

 Irritable – internalized feelings of tension associated with

being easily annoyed and provoked to anger

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Affect Descriptors

 Appropriate – consistent with content of person’s

speech or ideation

 Inappropriate when not consistent

 Broad – normal  Restricted – limited in expressive range and/or intensity  Blunted – marked by severe reduction in the intensity of

affective expression

 Flat – virtually no affective expression; voice is

monotonous and face is frequently immobile

 Labile – characterized by repeated, rapid, and abrupt

shifts

 e.g., tearful vs. combative vs. gregarious, vs. angry and abusive

without apparent reason

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Depression & Development

Infancy

Lethargy Feeding problem Sleep problem Irritability Sad expression Crying Failure to thrive Associated with maternal depression

Preschool

Lethargy Feeding problem Sleep problem Irritability Sad facial expression Crying Mood changes Hard to assess

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Depression & Development

 Middle childhood

 Begin to report hopelessness and self-

deprecation around age 9-12

 Throughout childhood: difficult/impossible

to disentangle depression from anxiety

 Measurement issue or developmental

phenomenon?

 Adolescent

 Begins to look more like adult depression

 May be differences between prepubertal

and postpubertal depression

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Major Depressive Disorder

 Point prevalence rate: 2% in school-age children; 4% in adolescents  1:1 gender ratio before puberty; female excess after puberty 1:2 males to females  Cumulative incidence by age 18: 20% of community samples  A majority of children w/depressive illness will have a recurrent illness: 20% - 60% by 1 to 2 years following remission; 70% after 5 years following remission (Birhaher et

  • al. 2002; Costello et al., 2002).

 Episodes typically last 8 wks – 9 months, and for more than 1- year for a significant majority [up to 14 months]

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Major Depressive Disorder

 The clinical picture in children is similar to that observed in adults with some exceptions:  Melancholy is usually not observed in children.  Suicide attempts are less frequent in children.  Lethality of suicide attempts is lower [note: children show a similar frequency of suicidal ideation & equal intent].  Children: higher frequency of comorbid separation disorder, phobias, somatic complaints, & externalizing problems [42% w/ADHD, 62% w/ODD, 41% w/both disorders – Luby et al., 2003].  Approximately 5% - 10% of children & adolescents have subsyndromal symptoms of MDD, including significant psycho- social impairment & increased risk of suicide & developing MDD [also have high family loading for depressive illness].

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Diagnosis of Major Depression and Dysthymia in Pediatric Patients

 Primary obstacle: children cannot reliably report their internal feelings [i.e., identify and label mood states].  Children are notoriously poor at reporting time concepts & questions in which they have to exercise judgment – use anchors and usually remembered dates (summer, holidays, birthdays).  Use simple questions asked sequentially rather than complex questions.  Must rely heavily on parental report, which in turn, is hampered by several variables including parental psychopathology, attachment/ closeness to child, observation of child, & ability to identify internal feelings in children [note: depressed mothers tend to over report depressive symptoms in their children].  Mood states are highly comorbid with ADHD, CD, and anxiety disorders.

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Important Predictors of Depression & Recurrent Depression

  • Comorbid nonaffective disorders predict a more severe course of

depression.

  • 45% of adolescents with a history of MDD develop a new episode of MDD

between the ages of 19 and 24 (i.e., annual reoccurrence rate of 9% over a 5-year time span).

  • Adolescents with MDD have an elevated rate of nonaffective disorders

between 19 and 24 years of age, as well as elevated antisocial and borderline personality traits relative to TD controls.

  • The prognosis of Adjustment Disorder is nearly as poor as for MDD –

rates of future MDD and nonaffective disorder for adolescents with adjustment disorder are as high as for those initially presenting with MDD.

  • Adolescents who succumb to adjustment disorder with depressed mood

in the face of a stressor are more vulnerable for developing future MDD as young adults (i.e., implies inherent vulnerability).

  • Nearly all adolescents with MDD & dysthymia also had a non-affective

disorder.

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Depression and Anxiety in Children

 Kovacs et al. (1989): 2/3’s of children with comorbid anxiety and depression develop anxiety before depressive symptoms.  Orvaschel et al. (1995): 64.5% of adolescents with anxiety disorder later develop a 2nd diagnosis of MDD; but only 6.5% with MDD first later develop an anxiety disorder.  Cole et al. (1998): Anxiety Depression  Depression & anxiety are highly stable temporal traits [.49-.74 over a 30 month interval]  High rates of depression & anxiety predict increases in these constructs over time.  The probability of developing depressive symptoms after manifesting symptoms of anxiety is 31%.  The probability of developing depressive symptoms without previous symptoms of anxiety is less than 1%.  There a 3-fold increase in the likelihood of experiencing depressive symptoms due to prior symptoms of anxiety but the converse does not hold.

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Important Predictors of Depression & Recurrent Depression

  • Greater severity, chronicity, multiple recurrent episodes,

comorbidity, hopelessness, residual subsyndromal symptoms, negative cognitive style, family problems, low SES, & exposure to

  • ngoing negative life events predict recovery, relapse, and

reoccurrence.

  • Dysthymia – characterized by a prolonged course, with a mean

episode of 3 – 4 years for clinical and community samples; also associated with an increased risk of subsequent MDD and substance abuse disorders (Kovacs et al., 1994).

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Best predictors of which depressed children will later develop bipolar disorder:

 Rapid onset  Psychosis  Psychomotor retardation  Psychotic features  Family history of bipolar disorder  Tricyclic induced hypomania

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19 Based on the following misconceptions:  Children are too immature cognitively and emotionally to experience core depressive affects.  Children younger than 9 do not have a sufficiently developed self-concept and thus could not experience the discrepancy between the real and ideal self that is a necessary precursor to guilt – a core emotion of depression.  Psychoanalytic – the superego has not fully developed at this age.  “Masked Depression” – conveys the notion that children will not express depression directly but rather indirectly through somatic complaints, aggression, and other nonaffective symptoms instead

  • f typical symptoms of depression (sadness, anhedonia, etc).

 Joaquim Puig-Antich (1982) study: many children presenting with with CD symptoms may have an underlying depressive illness & CD symptoms may resolve following successful Rx of depression.

Masked Depression

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Diagnosis of Depression in Children

Structured and Semi-Structured Clinical Interviews (e.g., K-SADS) CBLC/TRF:

  • 1. Depressed school-age children have significantly higher internalizing

T-scores relative to ADHD-ODD and no disorder children

  • 2. Depressed school-age children have significantly higher depression/

anxiety, withdrawal, and somatization subscale scores relative to children with ADHD/ODD and no disorder children. Symptoms not reported by typically developing controls:

  • a. Anhedonia 58% - high NPP: don’t exhibit it, you probably

don’t have depression [reported by 0% in typical children]

  • a. Withdrawn
  • b. Afraid to leave home
  • c. Unexcited
  • d. Sadness/irritability – high sensitivity – almost all children with

depression -- 98% -- report this symptom.

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21 A majority of children with primary affective disorder exhibit behavioral problems that are viewed by their parents as disturbing; however, these problems are not viewed as the child’s major problem (Carlson & Cantwell, 1980). The behavior problems of children with externalizing disorders are typically viewed as more serious by parents. A traditional evaluation with only the parent will miss approximately 60% of affective cases. ‘Masking behaviors’ are typically nothing more than presenting complaints. In children with depression – behavior problems are typically viewed as less severe and postdate the onset of depressive symptoms.

Diagnosing Depression in Children

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Major Depressive Disorder

 Primary Treatments

 Tricyclic Antidepressants (TCAs) or SSRIs

 Puig-Antich et al. “conduct disorder” study

 Cognitive behavioral intervention  Behavioral family systems therapy  Interpersonal psychotherapy

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Dysthymic Disorder

Depression less severe, but more chronic Depressed or irritable mood Appetite disturbance Sleep disturbance Low energy Low self-esteem Poor concentration Hopelessness Symptoms last for a year or more Double depression is a term used when the child has both MDD and dysthymia Dysthymia usually begins before MDD

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Dysthymic Disorder

 Primary Symptoms: Two or more from

previous slide

 Secondary symptoms: social withdrawal,

temper tantrums, poor schoolwork, poor peer relations, alcohol and substance use

 Onset: age 8.5  Course: Variable  Duration: At least 1 year; chronic,

variable, or remits

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Adjustment Disorder with Depressed Mood

Child has depressive symptoms in response to a clear stressor (e.g., move, divorce)

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Epidemiology

MDD the most common type

80% of kids with depression have MDD 10% have double depression 10% dysthymia May be underestimated Episodes common in adolescence Gender differences do not

  • ccur until age 13 when

girls report depression more often

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Course of major mood disorders

Time  Mood (+) (–) Hypomania Mania Dysthymia Major Depression Normal Range

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Psychosocial Treatments for Depression

 Cognitive Behavioral therapy (Beck)  Interpersonal Psychotherapy (Klerman)

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Cognitive Behavioral Therapy (CBT)

 Beck (Cognitive Therapy)  Ellis (Rational Emotive Behavior Therapy)

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Perceived absence of contingency between person's efforts and reinforcing nature of consequences that follow Target distorted perceptions Why is ability lacking?

Depression/Dysthymia

Physio/Chemical/ Hormonal Imbalances Efforts to Bring (+) Reinforcement Inadequate Perceptions of ability to control own world are distorted Target Environment Target Perceptions

Consider antidepressant medication Bx Rehearsal Bx Deficits

(Lack appropriate skills)

Inhibitions “Find other satisfactions” Reduce Anxiety Desensitization Prompting Modeling Self-monitoring Feedback

Therapist & Peer

“Learn to like what you're doing” Problem Solving, etc. Environment is Unresponsive

(Few reinforcements) Objectively competent, accurate perceptions i.e., the situation IS the problem

Rational Restructuring

Evaluate realistically demands and ability to meet then

Post-Competency

Change view of self-efficacy Reinforce New Thoughts & Behaviors

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31 Anxiety

Conditioned Instrumental Deficits

Lack of certain skills

Self- generated Statements Self-induced Behaviors Life Situations

Desensitization

Can client be taught to relax? Can client clearly imagine and become anxious? Will client agree to graduated exposure?

Modeling in vivo Imaginal Modeling Self- monitor Bx Rehearsal Overextending Self/ Too Much Responsibility Unrealistic Self- demands

Shoulds/Musts

Perception of Other's Reactions Desensitization Anxiety Level Supplements Coping Skills Modify Environment Yes Tenable Environment? No Rational Restructuring

Evaluate realistically demands and ability to meet then

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32 Reactions Emotional Behavioral Physiological

Heaviness in abdomen Closes book Sadness

Situation

Reading textbook

Cognitive Behavioral Therapy (CBT)

Core Belief

I’m incompetent

Intermediate Belief

If I don’t understand something perfectly, then I’m dumb

Automatic Thoughts

This is too hard. I’ll never understand this.

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Automatic Thoughts

Situation: Reading your textbook

Reader’s automatic thought

“This makes sense! Finally, a book that explains things clearly!”

“This is too general – when will I learn what I need to work with kids?”

“This book is a waste of money”

“I have to learn all this?! What if I don’t understand it?!?”

“This is too hard. I’ll never be a good therapist” The reader feels:

Mildly excited

Disappointed

Disgusted

Anxious

Sad

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Cognitive Behavioral Therapy (CBT)

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CBT: Eliciting automatic thoughts