On the Verge of a Biologics Golden Age David Meininger Executive - - PowerPoint PPT Presentation
On the Verge of a Biologics Golden Age David Meininger Executive Director, Molecular Discovery Department of Protein Sciences, Merck & Co., Inc. Biologics: Bringing Innovation to Merck From Virgils Fourth Eclogue Novus ordo seclorum Now
Biologics: Bringing Innovation to Merck
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Now comes the final era of the Sibyl’s song; The great order of the ages is born afresh. And now justice returns, honored rules return; Now a new lineage is sent down from high heaven.
Novus ordo seclorum
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Source: http://www.forbes.com/sites/matthewherper/2011/08/03/the- best-drug-companies-of-the-decade/
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Nature Rev Drug Disc (2009) 8, 609
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Top 10 Drugs: 2018 Predicted*
$ 8.7
$ 7.2
$ 6.8
10.Herceptin (cancer) $ 6.2
7 of the top 10 drugs in 2018 predicted to be Biologics
*EvaluatePharma, June 2013: World Preview 2013, Outlook to 2018
10.Avastin (cancer) $ 6.0
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Source data: Tabs database accessed September 23, 2013
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Source data: Tabs database accessed September 23, 2013
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Source data: Tabs database accessed September 23, 2013
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Abscissca Position (min) Rh (nm) Dt Mw Main Peak 19.779 5.62 ± 0.36 (4.45 ± 0.29) e-7 cm²/sec 162700 ± 0.6% Shoulder Peak 18.675 5.67 ± 0.65 (4.40 ± 0.5) e-7 cm²/sec 170200± 0.8%
SEC-MALS Analysis
Main peak Shoulder peak Ipilimumab (Medarex/BMS) runs as two peaks << 150 kDa by SEC, but split peak 150 kDa by SEC-MALS
BioSep-SEC-S 3000 Size 300x7.8mm with 5 micron particle size, PBS + 200mM NaCl pH7.4 0.5mL/min, 30 min, 10 ug Superdex 200 PBS+ 200mM NaCL pH 7.4 0.5mL/min, 60 min, 40 ug
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Protein Eng Des Sel (2010) 23, 549 Protein Eng Des Sel (2010) 23, 643
Thermal Stability Viscosity/Solubility
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+
Proprietary Conj. & Linker Chemistry mAb
w/ Ambrx Amino Acid Ambrx Amino Acid Optimized Antibody Conjugate
Orthogonal Conjugation Chemistry
DNA encoding mAb
O-tRNA Synthetase
1 2 3
Site-Specific Conjugation
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O O
Rational design to preserve ADCC and compliment binding
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Merck Biologics Discovery Merck External Scientific Affairs Merck Corporate Licensing Zymeworks Ambrx