NYU Non-Tuberculous Mycobacteria Program Research Leopoldo N. - PowerPoint PPT Presentation

NYU ¡Non-­‑Tuberculous ¡Mycobacteria ¡Program ¡ Research Leopoldo ¡N. ¡Segal, ¡MD, ¡MS ¡ Assistant ¡Professor ¡of ¡Medicine ¡ Division ¡of ¡Pulmonary ¡and ¡Cri>cal ¡Care ¡Medicine ¡ NYU ¡School ¡of ¡Medicine ¡ Pa>ent ¡Educa>on ¡ th November ¡9 , ¡2016

Faculty Disclosure Leopoldo ¡N. ¡Segal, ¡MD, ¡MS ¡ Relevant financial relationships with a commercial interest: No relevant commercial interests. 2

100" 90" FEV1% 80" 70" 60" 50" 40" 30" 20" 10" 0" Cough and Structural Damage of the Decline in Lung Sputum Production Lung Function ! Diagnosis F/U and Prognosis Treatment ! NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program

Diagnosis F/U and Prognosis Treatment Understanding the microbiome among us and within us Microbe Isolation Microbial Product Identification ! ! NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program Culture Dependent Culture Independent

Evalua8on ¡of ¡the ¡Airway ¡Microbiome ¡In ¡NTM Host Defense Disease Health 5

Microbial environment: e.g. Biofilm Host Defense Microbial Dynamics: • GERD • Impaired clearance Disease Health 6

Evalua8on ¡of ¡the ¡Airway ¡Microbiome ¡In ¡NTM NYU Langone NTM/Bronchiectasis Program Respiratory Symptoms + Imaging abnormalities Biomarker Cohort (n=200) Questionnaires Pulmonary Function NTM - NTM + Clinical Induced Sputum Oral Wash Case Control Sub-Study (n=40) NTM - NTM + Bronchoscopy 7

Are ¡there ¡differences ¡in ¡airway ¡microbiota ¡between ¡NTM+ ¡and ¡NTM-­‑? Oral Samples Sputum Samples � � � � � � � � � � � � � � � � � � � � � � � � � � � � PC1 (22%) � PC1 (21%) NTM - � � � � � � � � � � � � � � � � � � � � � � � � � � � NTM + � � � � � � NTM + � � � � � � � � � � � � NTM - � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � PC1 (37%) PC1 (42%) NTM+ NTM+ NTM- NTM- 8

Permissive Microbiota Supressive Microbiota Host Defense Host Defense Disease Health Disease Health 9

F/U and Prognosis NYU NTM/Bronchiectasis Cohort Upper Airway and Questionnaire Clinical and PFT Imaging Swallowing Evaluation Outcomes of Patients Treated and Not Treated for Nontuberculous Mycobacteria Treatment A Treatment B ! ! ! ! NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program

Treatment NYU NTM/Bronchiectasis Cohort Non-Pharmacologic • Pharmacologic = Clinical Trials • • Liposomal Amikacin for refractory MAC • Clofazamine for Recalcitrant NTM/ M. Abscessus • Liposomal Ciprofloxacin for Pseudomonas ! ! NYU LANGONE NTM/Bronchiectasis ! Multidisciplinary Program

Be involved!! Ask us about research opportunities NYU NTM/Bronchiectasis Program ! ! NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program 12

Be involved!! Ask us about research opportunities NYU NTM/Bronchiectasis Program Adrienne Scott, MS Imran Sulaiman, MS Will Wassmer Stephanie Lau, MD (Research Coordinator/Clinical Trials) (Research Associates) Sara Chambers Yonghua Li, MD Kathryn Norris, MS (Development) (Research Assistant/Lab) 13 (Research Coordinator/IRB)

Be involved!! Ask us about research opportunities NYU Langone NTM/Bronchiectasis Program Funding Support: NIH/NIAID K23 AI102970 (Career Development Award) We would like to acknowledge the generous support of donors to the NYU Langone NTM/bronchiectasis program: Barbara Goldstein Amster Helaine Lerner The Chelnik family in honor of Harriette and Martin Chelnik Beatrice Ifshin, NTM Info & Research Mona Wandler Karen Elliott House Leeam Lowin Sandra Pearl For more information about the program or opportunities for involvement, please contact Sara Chambers at sara.chambers@nyumc.org or 212-404-3538. e-mail: leopoldo.segal@nyumc.org 14