NYU Non-Tuberculous Mycobacteria Program Research Leopoldo N. - - PowerPoint PPT Presentation
NYU Non-Tuberculous Mycobacteria Program Research Leopoldo N. Segal, MD, MS Assistant Professor of Medicine Division of Pulmonary and Cri>cal Care Medicine
Leopoldo ¡N. ¡Segal, ¡MD, ¡MS ¡
Assistant ¡Professor ¡of ¡Medicine ¡ Division ¡of ¡Pulmonary ¡and ¡Cri>cal ¡Care ¡Medicine ¡ NYU ¡School ¡of ¡Medicine ¡ Pa>ent ¡Educa>on ¡ November ¡9
th
, ¡2016
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Structural Damage of the Lung Cough and Sputum Production
0" 10" 20" 30" 40" 50" 60" 70" 80" 90" 100"
FEV1%
Decline in Lung Function
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NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program
Diagnosis Treatment F/U and Prognosis
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NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program
Diagnosis Treatment F/U and Prognosis
Culture Independent Microbial Product Identification Microbe Isolation Culture Dependent
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Host Defense Health Disease
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Host Defense Health Disease Microbial environment: e.g. Biofilm Microbial Dynamics:
Bronchoscopy Questionnaires Pulmonary Function Clinical Induced Sputum Oral Wash
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NYU Langone NTM/Bronchiectasis Program Respiratory Symptoms + Imaging abnormalities Biomarker Cohort (n=200) NTM + NTM - NTM + NTM - Case Control Sub-Study (n=40)
NTM+ NTM- NTM+ NTM-
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Oral Samples
PC1 (37%) PC1 (22%)
Sputum Samples
PC1 (42%) PC1 (21%)
Are ¡there ¡differences ¡in ¡airway ¡microbiota ¡between ¡NTM+ ¡and ¡NTM-‑?
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Host Defense Health Disease Host Defense Health Disease
Permissive Microbiota Supressive Microbiota
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NYU LANGONE NTM/Bronchiectasis Multidisciplinary ProgramF/U and Prognosis
Outcomes of Patients Treated and Not Treated for Nontuberculous Mycobacteria
Treatment A Treatment B Questionnaire Clinical and PFT Imaging Upper Airway and Swallowing Evaluation
NYU NTM/Bronchiectasis Cohort
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NYU LANGONE NTM/Bronchiectasis Multidisciplinary ProgramTreatment NYU NTM/Bronchiectasis Cohort
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NYU LANGONE NTM/Bronchiectasis Multidisciplinary Program
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NYU NTM/Bronchiectasis Program
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NYU NTM/Bronchiectasis Program
Yonghua Li, MD (Research Assistant/Lab) Kathryn Norris, MS (Research Coordinator/IRB) Sara Chambers (Development) Stephanie Lau, MD (Research Coordinator/Clinical Trials) Adrienne Scott, MS Imran Sulaiman, MS Will Wassmer (Research Associates)
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NYU Langone NTM/Bronchiectasis Program
Funding Support: NIH/NIAID K23 AI102970 (Career Development Award) We would like to acknowledge the generous support of donors to the NYU Langone NTM/bronchiectasis program: Barbara Goldstein Amster Helaine Lerner The Chelnik family in honor of Harriette and Martin Chelnik Beatrice Ifshin, NTM Info & Research Mona Wandler Karen Elliott House Leeam Lowin Sandra Pearl
For more information about the program or opportunities for involvement, please contact Sara Chambers at sara.chambers@nyumc.org or 212-404-3538.
e-mail: leopoldo.segal@nyumc.org