New Vaccines for Prostate Cancer A/Prof Kristen Radford Cancer - - PowerPoint PPT Presentation

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Sep 30, 2022 285 likes •354 views

New Vaccines for Prostate Cancer A/Prof Kristen Radford Cancer Immunotherapies Group, Mater Research School of Biomedical Sciences, University of Queensland Translational Research Institute, Brisbane Australia kristen.radford@mater.uq.edu.au

SLIDE 1

New Vaccines for Prostate Cancer

A/Prof Kristen Radford

Cancer Immunotherapies Group, Mater Research School of Biomedical Sciences, University of Queensland Translational Research Institute, Brisbane Australia kristen.radford@mater.uq.edu.au

SLIDE 2

Teaching the immune system to fight cancer

1. Turning off the breaks

Immune checkpoint inhibitors

eg Ipilimumab (Yervoy, anti-CTLA-4) Tremelimumab (anti-CTLA-4) MEDI4736 (anti-PD-L1)

2. Transferring cancer-specific

killer T cells

Adoptive T cell therapies

3. Cancer vaccines

Dendritic cell therapies

eg Sipuleucil-T – Provenge, Dendreon

SLIDE 3

Dendritic cells are master regulators of immune responses

1. Initiate immune responses

against pathogens and cancers

2. Maintain tolerance and

homeostasis

SLIDE 4

Dendritic cell immunotherapy for cancer

>200 published clinical trials
Safe, low toxicity
Induction of anti-tumour immunity, some clinical benefit

SLIDE 5

Journal of Experimental Medicine, 2010

Identification of the “cancer fighting” DC in humans

SLIDE 6

vaccination

Antibody specific for “cancer fighting” DC cancer target(s)

lymph node tumour cells killer T cells

Immunotherapy targeting the “cancer fighting” DC

Advantages

Cancer targets directly reach the “cancer fighting” DC
Practical and cost effective manufacture
Applicable to a wider range of patients