Neural correlates of auditory short term memory in sensory cortex of - - PowerPoint PPT Presentation

Neural correlates of auditory short term memory in sensory cortex of the macaque

Corrie R. Camalier

Laboratory of Neuropsychology National Institute of Mental Health, NIH corrie.camalier@gmail.com CRESCENT Auditory Working Memory Workshop - 15 June 2017

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summary diagrams with pointers to the relevant papers.

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Other studies, areas yielded similarly low yield delay activity

core, belt parabelt: auditory cortex M L C

Lateral surface, macaque brain Scott, Mishkin, Yin 2014 Ng Plakke Poremba 2014 Bigelow, Rossi, Poremba 2014 Plakke Ng Poremba 2013

Distractor interference in mnemonic tasks

Auditory Cortex

Intact PFC critical for suppressing distracting auditory stimuli Chao and Knight 1998

Prefrontal Cortex Basal Ganglia

Intact BG important for gating irrelevant stimuli Aud WM(nonspatial!): Camalier et al 2017 Scott et al 2014 and LFP extension: neural correlates

• f distractor induced

suppression? Vis WM(spatial): Voytek and Knight 2010, McNab and Klingberg 2008, Baier 2010

Main points:

1) Nature of encoded representation 2) Shared (supramodal?) mechanisms for distractor interference

Delay period activity does not adequately explain mnemonic activity. Suppression of distractor via frontal/BG mediated mechanism? How is filter established? Nature of decay vs interference effects in STM (Baddeley 2012)