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MSC2009 August 19, 2009 1 Corporate Mission Pluristem Therapeutics, Inc. is an American bio- therapeutics company dedicated to the commercialization of allogeneic cell therapy products targeting a variety of degenerative, ischemic

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  1. MSC2009 August 19, 2009 1

  2. Corporate Mission Pluristem Therapeutics, Inc. is an American bio- therapeutics company dedicated to the commercialization of allogeneic cell therapy products targeting a variety of degenerative, ischemic and autoimmune disorders. 2

  3. Forward-Looking Statements This presentation contains forward-looking statements that involve certain risks and uncertainties associated with a development-stage company. Actual results could differ materially from those projected in the forward-looking statements as a result of the risk factors discussed in Pluristem reports on file with the U.S. Securities and Exchange Commission including, but not limited to, the report on Form 10-K for the year ended June 2007 www.pluristem.com 3

  4. Company Profile  Pluristem Therapeutics Inc. (NasdaqCM: PSTI; DAX: PJT)  Pluristem's headquarters, research and development, and cell Good Manufacturing Practices (cGMP) approved manufacturing facilities are located in Haifa, Israel. Pluristem employs 36 people, including six PhDs and one MD. The Company’s products are derived from the human  placenta, a non-controversial, non-embryonic, adult cell source.  The PLX (PLacental eXpanded) cell products are off-the- shelf, stored ready-to-use and require no histocompatibility matching. First product - PLX-PAD is in Phase I clinical trials in  Germany (Q2/2009) and in the USA (Q3/2009). 4

  5. From the Miracle of Birth to Therapeutics for All 5 5

  6. 3D PluriX Bioreactor • Protection of cells from shear stress. • Large surface area. • Control & monitoring of the process parameters. • Scalable systems. 6

  7. PLX Immunophenotypic Characteristics  Positive Markers: CD105, CD73, CD90 and CD29-highly expressed by PLX cells  Negative Markers: hematopoietic markers: CD45, CD34 CD19, CD14 and HLA-DR, and endothelial marker: CD31.  Intermediate levels of HLA major histocompatibility complex (MHC) class I molecules.  Do not express HLA class II antigens on the cell surface, and additional typical co-stimulatory molecules, which are typically expressed by antigen presenting cells, (APCs) such as CD80, CD86 and CD40.

  8. 8

  9. Secretion of Angiogenic Factors 5000 Hypoxia Normal 4000 VEGF pg/ml 3000 2000 1000 0 P110608A PLC19 P140708 P160408 091208B02 Secretion VEGF by PLX cells cultured for 24 hours under normal or hypoxic conditions 9

  10. PLX-PAD: Peripheral Artery Disease Peripheral arterial disease (PAD) - chronic disease that  progressively restricts blood flow in the limbs. Disease is often associated with: hypertension, cardiovascular  disease, hyperlipidemia, diabetes, obesity, stroke Critical Limb Ischemia (CLI) is the end stage of PAD.  CLI often leads to amputations and even to death.  PAD remains an under-appreciated condition.  10

  11. Mouse Model of Hind Limb Ischemia (Goto et al.,) 11

  12. Blood Flow : (Contact Doppler Laser) PBS PBS PLX-PAD PLX-PAD PLX-PAD P=0.0008 Control PBS Day 0 Day 0 Day 21 Day 21 12

  13. Angiogenesis: (Histological examination of capillary formation) PLX-PAD Control PBS P=0.021 Histology sections of tissue from limb ischemic mice after treatment with PLX stained with Hematoxilin Eosine (H&E). Increase in capillary density in mice treated with PLX-PAD can be observed (arrows). 13

  14. Oxidative Stress (nitrotyrosine) Endothelial Inflammation (VCAM) PLX-PAD Control PBS P=0.034 P=0.004 The histological and the immunohistological data strongly correlate to the improvement in blood flow and functionality in PLX-PAD treated mice 14

  15. Phase I Clinical Plan US  Locations: - Duke University Medical Center P.I. – Christopher Kantos MD - Center for Therapeutic Angiogenesis (supported by the Univ. of Alabama) P.I. – Ferrell Mendelsohn MD  Subjects: - 12 patients - Rutherford category 4-5  Dose: - Open label - Dose escalation study -Two dosage groups (single and double administration), outpatient -PLX-PAD – IM injections above and below the knee  Follow Up: - Clinical F/U - 3 months -Tumorigenicity F/U – 12 months 15 15

  16. Phase I Clinical Plan Europe  Locations: - Franziskus-Krankenhaus Hospital, Berlin P.I. – Prof. Carsten Tschöpe, MD - Charite - Universitatsmedizin Hospital, Berlin P.I. – Prof. Carsten Tschöpe, MD  Subjects: - 15 patients - Rutherford category 4-5  Dose: - Open label - Dose escalation study -Three dosage groups (single administration), inpatient -PLX-PAD – IM injections above and below the knee  Follow Up: - Clinical F/U - 3 months -Tumorigenicity F/U – 24 months 16 16

  17. Phase I Clinical Plan Eligibility  40 Years to 81 Years  Both Genders Eligible  Inclusion Criteria :  Diagnosis of CLI as defined as persistent, recurring ischemic rest pain for at least two weeks, and/or ulceration or gangrene of the foot or toe, with ABI < 0.4 or/and TBI < 0.4 or transcutaneous partial pressure of oxygen ≤ 30 mmHg pO2 at the foot  Rutherford category 4-5  No acceptable options for re-vascularization as confirmed by angiographic imaging or by color flow duplex ultrasound obtained within 6 months prior to screening. In the opinion of the investigator, major amputation is not anticipated over a  period of three (3) months. 17 17

  18. Phase I Clinical Plan Eligibility  Exclusion Criteria:  Uncontrolled hypertension (defined as diastolic blood pressure > 110 mmHg or systolic blood pressure > 180 mmHg during screening).  Poorly controlled diabetes mellitus (HbA1c > 9%)  Wounds with severity greater than Grade 2 on the Wagner Scale  Life-threatening ventricular arrhythmia - except if an ICD is implanted - or unstable angina pectoris - characterized by increasingly frequent episodes with modest exertion or at rest, worsening severity, and prolonged  ST segment elevation myocardial infarction and/or TIA/CVA within six (6) months prior to enrollment.  Patients with severe congestive heart failure (i.e. NYHA Stage IV)  In the opinion of the investigator, the patient is unsuitab le for cellular therapy . 18 18

  19. Clinical Study Design End Points  Safety endpoints – Adverse events – Amputation incidence – Death incidence – Rehospitalization incidence – Safety laboratory values and ECG findings – Immunological reactions  Efficacy parameters – Hemodynamic assessments – ankle-brachial pressure index (ABI) – toe brachial index (TBI) – transcutaneous oxygen pressure (tcPO2) – Wound assessment – Wagner Scale – Pain assessment - VAS – QOL questionnaire – Kings College VascuQol 19 19

  20. Clinical Study Design End Points  Safety endpoints – Adverse events – Amputation incidence – Death incidence – Rehospitalization incidence – Safety laboratory values and ECG findings – Immunological reactions  Efficacy parameters – Hemodynamic assessments – ankle-brachial pressure index (ABI) – toe brachial index (TBI) – transcutaneous oxygen pressure (tcPO2) – Wound assessment – Wagner Scale – Pain assessment - VAS – QOL questionnaire – Kings College VascuQol 20 20

  21. MSC2009 William R. Prather RPh, MD Sr. VP Corp Development bill@pluristem.com 21

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