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S YSTEMATICALLY T RANSFORMING C ANCER I MMUNOTHERAPY Legal Information & Disclaimer This presentation includes forward-looking statements concerning our business, operations and financial performance and condition, as well as our plans,


  2. Legal Information & Disclaimer This presentation includes forward-looking statements concerning our business, operations and financial performance and condition, as well as our plans, objectives and expectations for our business operations and financial performance and condition. Any statements contained in this presentation or expressed orally in connection herewith that are not statements of historical fact may be deemed to be forward-looking statements. In some cases, forward-looking statements can be identified by phrases such as “plans,” “intends,” “believes,” “expects,” “anticipates,” “foresees,” “forecasts,” “estimates” or other words or phrases of similar import. Similarly, statements herein that describe our business strategy, outlook, objectives, plans, intentions or goals also are forward-looking statements. All such forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Accordingly, you should not place undue reliance on our forward-looking statements. The forward-looking statements contained in this presentation or expressed orally in connection herewith are made only as of the date of this presentation and we undertake no obligation to update the forward-looking statements to reflect subsequent events or circumstances, except as required by applicable law. None of ImmunSYS, Inc., its affiliates or their respective directors, officers, employees or agents gives any representation or warranty, express or implied, as to: (i) the achievement or reasonableness of future projections, management targets, estimates or prospects contained in this presentation; or (ii) the accuracy or completeness of any information contained in this presentation, any other written information or oral information provided in connection herewith or any data that any of them generates. This presentation was prepared by us for informational purposes only, for delivery to a limited number of parties who may be interested in exploring a potential transaction with us, and does not constitute an offer, or solicitation of an offer, to sell any securities at any time. Any securities referred to in this presentation or orally in connection herewith have not been registered under the Securities Act of 1933, as amended, or any state securities law. Such securities have not been approved or disapproved by the Securities and Exchange Commission or by any state securities regulatory authority, nor has the Securities and Exchange Commission or any such state authority passed on the accuracy or adequacy of this presentation. Any representation to the contrary is a criminal offense. This presentation should be held in strict confidence by you, and must not be photocopied or reproduced in any other electronic or physical form and its contents must not be communicated, disclosed or distributed to any other person in whole or in part. If you wish to pursue this opportunity, you will need to rely on your own inspection and due diligence. Certain of the information contained in this presentation may be derived from information provided by industry sources. We believe that such information is accurate and that the sources from which it has been obtained are reliable; however, we cannot guaranty the accuracy of such information and have not independently verified such information. 2

  3. Company Snapshot Company: ImmunSYS, Inc. is a clinical stage immunotherapeutic development company focusing on solid tumor cancers with an initial focus on metastatic prostate cancer Technology : YourVaccx ™* is a proprietary intra-tumoral combination drug/device immunotherapy system that has delivered a 46% Objective Response Rate, including a 38% Complete Response Rate of metastatic disease, with 62% of patients achieving a > 50% PSA decline in a Proof of Concept (PoC) clinical study on metastatic prostate cancer patients Minimally Invasive: Outpatient procedure, that is relatively low cost Headquarters : Fort Lauderdale, FL Strong Intellectual Property Position: An issued patent covering our foundation antigen exposure technology; 8 pending patent applications in the US; 36 additional patent applications pending worldwide *YourVaccx is the name of the therapy, not the name of the drug or device used. The drug will be named via FDA approval process. The YourVaccx trademark has been selected to avoid confusion with other marks and provide stronger protection. 3

  4. YourVaccx ™ : Customized Cancer Therapy 4

  5. YourVaccx ™ Advantages Over Current Therapies Since there are no known viable therapies for very late stage prostate cancer, YourVaccx™ provides tremendous advantage to patients who have been referred to hospice care and have been told to quickly settle their affairs. Currently available immunotherapies have been extensively tested in prostate cancer clinical trials with consistently poor results. Many cancers show extensive antigenic variability. YourVaccx™ is designed to expose the patient’s immune system to the antigens of his own tumors, thereby eliciting immune responses that are tailored to each patient’s unique cancer. 5


  7. PoC Clinical Study Treatment Success The YourVaccx ™ System developer, Dr. Gary Onik* treated a series of 13 metastatic prostate cancer patients with diffuse systemic disease. o Each patient was incurable with available therapies. Dr. Onik and his collaborators achieved a 46% Objective Response Rate, including a 38% Complete Response Rate of metastatic disease, with 62% of patients achieving a > 50% PSA decline that has been durable up to 49 months thus far, which constitutes unprecedented success and PoC. The Proof of Concept (PoC) study also included patients with other types of late stage cancers which resulted in very encouraging results. Identifier: NCT03695835 Expect to publish the PoC clinical study results in 2019 *Dr. Onik is the Executive Vice President, Chief Medical Officer, a director and an indirect stockholder of ImmunSYS, Inc. 7

  8. Metastatic Prostate Cancer PoC Study Methodology Retrospective Analysis of Practice of Medicine Proof of Concept (PoC) Single Center Case Series Institutional Review Board (IRB) Approved Contract Research Organization (CRO) Monitored N =13 patients with metastatic prostate cancer who signed informed consent to participate in the study Each received YourVaccx™ as the only therapy for metastatic disease 8

  9. PoC Prostate Cancer Patient Efficacy Data (range: 5 to 49 months) Result # Patients % Objective Response Rate (ORR) 6 / 13 46% Complete response (CR) of metastatic disease 5 / 13 38% CRs for metastases successfully treated for residual primary 2 / 2 100% CR castrate resistant (CRPC) 2 / 5 40% PSA decline ≥ 50% 8 / 13 62% Studies of Provenge (the only approved immunotherapy for prostate cancer) did not show objective PSA or radiographic responses For clarification of abbreviations and terms, please refer to the Key Terminology & Definitions slide at the end of the presentation. 9

  10. PoC Prostate Cancer Patient Safety Data (range: 5 to 49 months) Adverse Events # Patients = 13 Hyperkalemia 1/13 (8%) 3 patients had SAEs, including nausea and vomiting (prolonged Hypothyroidism 1/13 (8%) hospitalization); prostate abscess; and Elevated BUN and creatinine 1/13 (8%) left perinephric abscess Urinary retention 1/13 (8%) 1 unrelated death 19 months post Elevated ALT and AST 1/13 (8%) treatment due to complications of subsequent hiatal hernia surgery SIAHS 1/13 (8%) Short term memory loss 1/13 (8%) Chest pain 1/13 (8%) 10

  11. Gary Onik, M.D. – Inventor, Physician & Patient Dr. Onik was diagnosed with a very aggressive metastatic prostate cancer in October 2018. o Metastasized to bone, pelvis and distant areas o PSA of 137 He underwent the YourVaccx ™ therapy, receiving the standard 2 treatments (one in early December 2018 and one in late December 2018). His first follow-up was February 1 st , 2019 11

  12. Dr. Onik’s Initial Results After Before CRF #29 Scans at 6 weeks post therapy Bone mets are completely inactive Small distant mets have resolved Large mass in pelvic region is almost completely absent PSA reduction at time of scan from 138 to 0.6 PSA at 5 months remains at 0.6 Demonstrates durable Complete Response 12

  13. CRF #7 - Representative Patient Case Study CRF #7 75 yr old male with bladder and Before After rectal invasion, obstruction of both ureters and a suprapubic tube and nodal metastases Previous surgical procedures and therapies: o Radical prostatectomy (failed) o Radiation therapy (failed) o CRPC » Failed Lupron, Casodex, Zytiga » Failed 13 rounds of chemo (Taxotere, Carbazetaxel) Hospice was scheduled Patient is now 4 years post- therapy and still free of disease 13

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