Kidney Transplantation Committee Fall 2015 1 Policy & - - PowerPoint PPT Presentation

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Kidney Transplantation Committee

Fall 2015

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Policy & Guidance Implementation Dates

Title Summary Implementation Date

Marking Kidney Laterality Guidance Document Develop laterality marking practices and crosscheck marking before packaging June 2, 2015 Convert KPD Contact Responsibilities and Donor Pre- Select Requirements from the OPTN/UNOS KPDPP Operational Guidelines into OPTN Policy Requires donor pre-select for highly sensitized candidates (>=90% CPRA) Creates process and deadlines for receiving and accepting match offers Only applies to OPTN KPDPP Match offer process – Pending Programming All other policy changes – September 1, 2015 Informed Consent for Kidney Paired Donation (KPD) Requires informed consent for paired candidates and donors, non-directed donors, and bridge donors participating in ANY KPD program December 1, 2015

• Clarify KAS policy language

based on community feedback

• Anticipated Public Comment

Period: January 2016

• Anticipated Board Date: June

2016

KAS Clarifications & Clean Up

Committee Projects

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KAS: The First Six Months

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• KAS implemented Dec 4, 2014
• Key goals:
• Make better use of available kidneys
• Increase transplant opportunities for difficult-to-match patients (increased

equity)

• Increase fairness by awarding waiting time points based on dialysis start date
• Have minimal impact on most candidates

Background

• Performance tracked monthly through June (“out of the gate” reports)
• Comprehensive, 6-month analysis requested by the kidney committee
• Pre-KAS period: June 1, 2013 – December 3, 2014 (18 months)
• Post-KAS period: December 4, 2014 – May 31, 2015 (6 months)

Background

(http://optn.transplant.hrsa.gov)

Who’s getting transplanted under KAS?

Percentage of Deceased Donor Kidney Transplants by Recipient Age

• More young candidates (18-49) are receiving kidney transplants.
• Still, over half of transplants are going to age 50+ recipients under KAS.

0.9% 9.6% 25.5% 43.0% 20.9% 4.3% 8.9% 23.8% 40.9% 22.2% 3.6% 13.5% 28.5% 37.4% 17.0%

0% 25% 50%

0-17 18-34 35-49 50-64 65+

Recipient age

Waitlist (11/30/2014) Pre-KAS Post-KAS

Who’s getting transplanted under KAS?

Percentage of Deceased Donor Kidney Transplants by Recipient Race/ethnicity

• More African Americans are receiving kidney transplants.
• Transplants have also increased for Hispanics, but declined for Whites.

34.3% 36.5% 7.9% 19.2% 0.6% 1.1% 0.5% 31.5% 42.4% 7.1% 16.9% 0.6% 1.1% 0.5% 37.9% 34.2% 6.8% 18.4% 0.6% 1.5% 0.6%

0% 25% 50%

Recipient Race/Ethnicity

Waitlist (11/30/2014) Pre-KAS Post-KAS

Who’s getting transplanted under KAS?

Percentage of Deceased Donor Kidney Transplants by Recipient Blood Type

• The distribution of transplants has changed little by recipient ABO.
• Slight increases for blood type B and AB patients.

28.4% 16.5% 2.8% 52.3% 37.0% 12.9% 4.9% 45.1% 35.3% 13.3% 6.4% 44.9%

0% 25% 50% 75%

A B AB O

Recipient blood type

Waitlist (11/30/2014) Pre-KAS Post-KAS

Who’s getting transplanted under KAS?

Percentage of Deceased Donor Kidney Transplants by Recipient CPRA

• Transplants have increased sharply for CPRA 99-100% patients.
• Transplants have declined for CPRA=0% and 80-94% patients.

61.8% 22.5% 4.2% 3.1% 8.3% 60.2% 23.9% 10.0% 3.5% 2.3% 55.3% 21.2% 4.9% 3.8% 14.8%

0% 25% 50% 75%

1-79 80-94 95-98 99-100

Recipient CPRA

Waitlist (11/30/2014) Pre-KAS Post-KAS

Who’s getting transplanted under KAS?

Percentage of Deceased Donor Kidney Transplants by Recipient Duration on Dialysis

• More transplants are going to long dialysis duration recipients.
• Fewer preemptive (before dialysis) transplants.

14.9% 9.1% 49.5% 21.3% 5.2% 8.8% 11.0% 50.0% 26.1% 4.2% 5.1% 6.9% 39.4% 35.5% 13.2%

0% 25% 50% 75%

Preemptive 0-1 1-5 5-10 10+

Recipient duration on dialysis (years)

Waitlist (11/30/2014) Pre-KAS Post-KAS

• 0 ABDR mismatches declined from 8.5% to 4.5% of transplants
• Slight increase in transplants to female recipients
• Under KAS, transplant rates have remained high for prior living

donors (approx. 20 times the average patient)

• Four-fold increase in A2/A2BB transplants (22  95 per year)

Who’s getting transplanted under KAS?

Other Findings

Longevity-matching under KAS

Percentage of Deceased Donor Kidney Transplants by KDPI and Recipient Age

• Transplants with KDPI 0-20% and recipient age 18-34:
• Pre-KAS: 2.5% of transplants / Post-KAS: 6.7% of transplants
• Transplants with KDPI 0-20% and recipient age 50+:
• Pre-KAS: 10% of transplants / Post-KAS: 4% of transplants

KDPI 0-20 KDPI 21-34 KDPI 35-85 KDPI 86-100 KDPI 0-20 KDPI 21-34 KDPI 35-85 KDPI 86-100 % % % % % % % % % % 0-17 2.9 0.8 0.6 0.0 4.3 0-17 2.5 0.9 0.2 0.0 3.6 18-34 2.5 1.9 4.4 0.1 8.9 18-34 6.7 2.4 4.3 0.1 13.5 35-49 5.5 4.5 13.2 0.6 23.8 35-49 7.3 4.7 15.9 0.6 28.5 50-64 7.1 6.5 23.6 3.7 40.9 50-64 2.8 6.0 25.4 3.3 37.4 65 Plus 2.9 2.6 13.1 3.6 22.2 65 Plus 1.0 2.2 10.9 3.0 17.0 All 20.9 16.2 54.8 8.1 100.0 All 20.3 16.2 56.5 7.0 100.0 POST-KAS (12/4/2014-5/31/2015) AGE KDPI All PRE-KAS (6/1/2013-12/3/2014) AGE KDPI All

Longevity-matching under KAS

• Of KDPI 0-20% kidney transplants, 61% are going to EPTS Top 20% recipients

under KAS.

• Under KAS, over half (52%) of EPTS Top 20% recipients received a KDPI 0-20%

kidney.

• However, a higher % of KDPI>85% kidneys are going to patients under age 50

(8.4% vs. 10% after KAS)

Geographic distribution of kidney transplants

67.8% 12.8% 19.5%

Post-KAS

Local Regional National 78.8% 8.7% 12.5%

Pre-KAS

Local Regional National

• More kidneys are being distributed outside recovery OPO’s DSA.
• CIT>24 hours: Pre-KAS 18.1%, Post-KAS 22.1%.

21.2% 32.3%

Geographic distribution of kidney transplants

• No significant changes by OPTN region.

3.9% 12.5% 13.3% 9.3% 17.1% 4.5% 7.1% 7.2% 6.1% 7.9% 11.2% 3.5% 12.6% 14.0% 9.8% 18.0% 3.9% 6.6% 6.8% 6.2% 7.7% 10.9%

0% 25%

1 2 3 4 5 6 7 8 9 10 11

OPTN Region

Pre-KAS Post-KAS

Kidney recovery & utilization under KAS

• Total kidney donors recovered per month increased 4% (636 to 661).
• The distribution by KDPI has remained very similar.

Percentage of Recovered Deceased Kidney Donors by KDPI

19.4% 14.4% 51.7% 14.5% 18.8% 14.0% 53.0% 14.1% 0% 20% 40% 60%

0-20 21-34 35-85 86-100 KDPI

Pre-KAS Post-KAS

Kidney recovery & utilization under KAS

• Kidney discard rates have increased by about 10%.
• Increase largest for, but not limited to, KDPI>85% kidneys.

Kidney Discard Rate by KDPI

2.3% 6.2% 17.4% 55.6% 18.5% 2.0% 7.3% 19.2% 61.9% 20.2%

0% 25% 50% 75%

0-20 21-34 35-85 86-100 Overall

KDPI Pre-KAS Post-KAS

Other Findings

• # of kidneys with final acceptance but transplanted to a different patient (or

discarded) increased from 9% to 11% due to more non-local sharing.

• Delayed graft function (DGF) rates increased from 25% to 31%.
• Graft outcomes & other measures will be evaluated in later reports.

• Overall – KAS is meeting key goals
• Increase in the number of transplants among sensitized patients
• Increase in access for African Americans; room for growth in A2/A2BB

transplants

• Fewer longevity mismatches
• Transplant volume is up (1%)
• However, several effects deserve further attention:
• Logistical challenges in allocation
• Increase in discard rates
• Increased CIT and DGF

Summary: First Six Months of KAS

• Dr. Mark Aeder

Committee Chair Mark.Aeder@uhhospitals.org Regional representative name (RA will complete) Region X Representative email address Melinda Woodbury Committee Liaison Melinda.Woodbury@unos.org

Questions?

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