In the news Nasdaq:JAN 1 JA JAN101 improves endothelial - PowerPoint PPT Presentation

NATURE REVIEWS IMMUNOLOGY In the news Nasdaq:JAN 1

JA JAN101 improves endothelial cell/vascular function Sustained release nitrite Treatment increases markers for increases vascular growth vessel growth (angiogenesis) COVID-19 is believed to attack endothelial cells causing significant tissue inflammation and damage Nitrite therapy induces angiogenesis in diabetic tissue Angiogenic Index 1.0 0.5 0.0 Nitrite Isc NI PBS Isc Nitrite NI PBS NI PBS Isch Nitrite NI Nitrite Isch PBS 2

Potential b benefits o of t treating C COVID-19 p patients w with s sodium n nitrite Increased angiogenesis in pigs Prevents tissue necrosis in diabetic mice In various animal studies, JAN101 has demonstrated positive benefits that align with COVID-19 complications • Reduces kidney damage • Prevents tissue necrosis Nitrite reduces thrombosis in mice • Reduces thrombosis • Increases angiogenesis From Kramkowski et al (2017) Naunyn-Schmiedeberg’s Arch Pharmacol 390:85-94 3

Ni Nitrite improves vascular fu function in humans Using flow-mediated dilation imaging technology we can assess vascular function improvement in patients with complications including blood flow and thrombosis Change(in(Flow(Mediated(Dila7on( (Least(Square(Means)( 2# Difference(in(%(Change( 1# 0# (from(Baseline( !1# Placebo# !2# !3# 40!mg# !4# 80!mg# !5# !6# FAS# Per!Protocol# Exploratory# Diabe<c# Popula7on( Placebo 40-mg 80-mg PAD Patients Healthy Subjects 4

Th The JAN AN101 COVID-19 v 19 vas ascular lar t trea eatmen ent o opportunit ity As indicated in multiple human trials, our current sodium nitrate compound may be a successful treatment for the vascular Intend to seek emergency complications experienced by COVID-19 patients use authorization Expanding existing JAN101 IND for • Shown to improve vascular function clinical study to treat COVID-19 • Shown to reduce vascular complications such as thrombosis vascular complications • Protects major organs from tissue damage due to poor blood flow • Inhibits inflammation, including mitigating the “cytokine storm”, a massive release of cytokine proteins that destroy endothelial cells (cells that protect the lining of vessel tissue) • Nitrite has proven to be well tolerated and safe 5