In the news Nasdaq:JAN 1 JA JAN101 improves endothelial - - PowerPoint PPT Presentation

▶
in the news
SMART_READER_LITE
LIVE PREVIEW

In the news Nasdaq:JAN 1 JA JAN101 improves endothelial - - PowerPoint PPT Presentation

Oct 31, 2023 171 likes •238 views

NATURE REVIEWS IMMUNOLOGY In the news Nasdaq:JAN 1 JA JAN101 improves endothelial cell/vascular function Sustained release nitrite Treatment increases markers for increases vascular growth vessel growth (angiogenesis) COVID-19 is believed to

slide-1
SLIDE 1

NATURE REVIEWS IMMUNOLOGY

In the news

1

Nasdaq:JAN

slide-2
SLIDE 2

JA JAN101 improves endothelial cell/vascular function

NI PBS Isc Nitrite NI Nitrite Isc PBS NI PBS Isch Nitrite NI Nitrite Isch 0.0 0.5 1.0

Angiogenic Index

PBS

Nitrite therapy induces angiogenesis in diabetic tissue Sustained release nitrite increases vascular growth Treatment increases markers for vessel growth (angiogenesis)

COVID-19 is believed to attack endothelial cells causing significant tissue inflammation and damage

2

slide-3
SLIDE 3

Potential b benefits o

  • f t

treating C COVID-19 p patients w with s sodium n nitrite

Increased angiogenesis in pigs Prevents tissue necrosis in diabetic mice

From Kramkowski et al (2017) Naunyn-Schmiedeberg’s Arch Pharmacol 390:85-94

Nitrite reduces thrombosis in mice In various animal studies, JAN101 has demonstrated positive benefits that align with COVID-19 complications

  • Reduces kidney damage
  • Prevents tissue necrosis
  • Reduces thrombosis
  • Increases angiogenesis

3

slide-4
SLIDE 4

Ni Nitrite improves vascular fu function in humans

Using flow-mediated dilation imaging technology we can assess vascular function improvement in patients with complications including blood flow and thrombosis

!6# !5# !4# !3# !2# !1# 0# 1# 2# FAS# Per!Protocol# Exploratory# Diabe<c# Difference(in(%(Change( (from(Baseline( Popula7on(

Change(in(Flow(Mediated(Dila7on( (Least(Square(Means)(

Placebo# 40!mg# 80!mg#

Healthy Subjects

Placebo 40-mg 80-mg

PAD Patients

4

slide-5
SLIDE 5

Th The JAN AN101 COVID-19 v 19 vas ascular lar t trea eatmen ent o

  • pportunit

ity

As indicated in multiple human trials, our current sodium nitrate compound may be a successful treatment for the vascular complications experienced by COVID-19 patients

  • Shown to improve vascular function
  • Shown to reduce vascular complications such as thrombosis
  • Protects major organs from tissue damage due to poor blood flow
  • Inhibits inflammation, including mitigating the “cytokine storm”,

a massive release of cytokine proteins that destroy endothelial cells (cells that protect the lining of vessel tissue)

  • Nitrite has proven to be well tolerated and safe

Intend to seek emergency use authorization

Expanding existing JAN101 IND for clinical study to treat COVID-19 vascular complications

5