HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE - - PowerPoint PPT Presentation

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HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE - - PowerPoint PPT Presentation

Jan 06, 2023 255 likes •675 views

HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE TLE ? AN N APPROACH H TO O VIRU IRUS S STRUCTU RUCTURE RE PEDRAM EDRAM AHMADPOOR ADPOOR.MD .MD S1 :receptor binding S2 : cell membrane fusion ssRNA virus S1 :receptor

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HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE TLE ? AN N APPROACH H TO O VIRU IRUS S STRUCTU RUCTURE RE PEDRAM EDRAM AHMADPOOR ADPOOR.MD .MD

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S2 :cell membrane fusion S1 :receptor binding

ssRNA virus

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S2 :cell membrane fusion S1 :receptor binding

ssRNA virus

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NO NORMAL AL BODY RESPONSE NSE TO VIRAL L INFEC ECTI TIONS ONS

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Journal of Bacteriology and Virology 2011. Vol. 41, No. 3 p.133 – 146 longer-dsRNA

ROTA

SARS-COV2 CMV

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Journal of Bacteriology and Virology 2011. Vol. 41, No. 3 p.133 – 146 longer-dsRNA

ROTA

SARS-COV2 CMV

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IFN-g

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BLOCKING INTERFERONS  MORE VIRAL REPLICATION UNABLE TO MOUNT ADAPTIVE IMMUNE RESONSE

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Functions of interferon class I

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biochemical pharmacology 72 (2006) 1469–1476 DC maturation

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biochemical pharmacology 72 (2006) 1469–1476

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THE OTHER SIDE OF THE COIN

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CD24+CD38+

CD40L CD40

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CD24+CD38+

CD40L CD40

MESSAGE WE NEED A DELICATE AND WELL ADAPTED QUANTITY OF INTERFERON

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Cold Spring Harb Perspect Biol 2014;6:a016295

TGF B/AHR THF-FDC IL IL-21 21

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Cold Spring Harb Perspect Biol 2014;6:a016295

TGF B/AHR THF-FDC IL IL-21 21

THE OTHER SIDE OF THE COIN

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SUPPRESSOR OF CHEMOKINE SIGNALING (SOCS) Tolerogenic DCs Blocking nfkb IL 10 secretion

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CROSSTALK BETWEEN IL-6 AND INTERFERON GAMMA

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SARS-COV-2

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BLOCKING THE KEY ELEMENT OF INNATE IMMUNITY AGAINST VIRUS

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Mounting an appropriate adaptive response needs a precise and delicate cross talk between DC,T /B cells and interferons / IL-6…

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THANKS NKS FOR OR YOU OUR R ATTENT ENTION ION

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SOCS expression