HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE - PowerPoint PPT Presentation

Jan 06, 2023 •255 likes •675 views

HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE TLE ? AN N APPROACH H TO O VIRU IRUS S STRUCTU RUCTURE RE PEDRAM EDRAM AHMADPOOR ADPOOR.MD .MD S1 :receptor binding S2 : cell membrane fusion ssRNA virus S1 :receptor

HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE TLE ? AN N APPROACH H TO O VIRU IRUS S STRUCTU RUCTURE RE PEDRAM EDRAM AHMADPOOR ADPOOR.MD .MD
S1 :receptor binding S2 : cell membrane fusion ssRNA virus
S1 :receptor binding S2 : cell membrane fusion ssRNA virus
NO NORMAL AL BODY RESPONSE NSE TO VIRAL L INFEC ECTI TIONS ONS
ROTA CMV SARS-COV2 longer-dsRNA Journal of Bacteriology and Virology 2011. Vol. 41, No. 3 p.133 – 146
ROTA CMV SARS-COV2 longer-dsRNA Journal of Bacteriology and Virology 2011. Vol. 41, No. 3 p.133 – 146
IFN-g
BLOCKING INTERFERONS  MORE VIRAL REPLICATION UNABLE TO MOUNT ADAPTIVE IMMUNE RESONSE
Functions of interferon class I
DC maturation biochemical pharmacology 72 (2006) 1469 – 1476
biochemical pharmacology 72 (2006) 1469 – 1476
THE OTHER SIDE OF THE COIN
CD40 CD40L CD24+CD38+
CD40 MESSAGE WE NEED A DELICATE AND WELL ADAPTED QUANTITY OF INTERFERON CD40L CD24+CD38+
TGF B/AHR THF-FDC IL IL-21 21 Cold Spring Harb Perspect Biol 2014;6:a016295
TGF B/AHR THE OTHER SIDE OF THE COIN THF-FDC IL IL-21 21 Cold Spring Harb Perspect Biol 2014;6:a016295
SUPPRESSOR OF CHEMOKINE SIGNALING (SOCS) Tolerogenic DCs Blocking nfkb IL 10 secretion
CROSSTALK BETWEEN IL-6 AND INTERFERON GAMMA
SARS-COV-2
BLOCKING THE KEY ELEMENT OF INNATE IMMUNITY AGAINST VIRUS
Mounting an appropriate adaptive response needs a precise and delicate cross talk between DC,T /B cells and interferons / IL-6 …
THANKS NKS FOR OR YOU OUR R ATTENT ENTION ION
SOCS expression

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