How MR Research Can Help Your How MR Research Can Help Your P P - PowerPoint PPT Presentation

“How MR Research Can Help Your “How MR Research Can Help Your P P Program and Improve Your Program and Improve Your d I d I Y Y chances for Grant Funding” chances for Grant Funding” E. Mark E. Mark Haacke Haacke, PhD , PhD - - Director Director MR Research Facility MR Research Facility - - Dept. of Radiology, School of Medicine Dept. of Radiology, School of Medicine Wayne State University, Detroit, MI Wayne State University, Detroit, MI The Vaitkevicius Magnetic Resonance Research Facility

Magnetic Resonance Research Research  Imaging  S  Spectroscopy It provides: It provides:  Structural  F  Functional and ti l d  Metabolic Information 2 LOGO

Magnetic Resonance Imaging Imaging  Imaging is one of the top ten discoveries in the last 1 000 years in the last 1,000 years.  Non – invasive  Non – ionizing N i i i  High resolution images  3D data acquisition  Human and animal scanners  Future materials imaging 3 LOGO

Magnetic Resonance Imaging Imaging  Imaging is one of the top ten discoveries in the last 1 000 years in the last 1,000 years.  Developed in 1970’s by Lauterbur and Mansfield Mansfield  Umbrella of all imaging modalities today  Constantly expanding and rapidly growing C t tl di d idl i  From basic physics experiments  To numerous clinical applications T li i l li i 4 LOGO

MR Research Facility  The Research Human MR Scanner  Located in Harper University Hospital L t d i H U i it H it l • 3T Verio high field human Siemens scanner LOGO

MR Research Facility  The Research Animal MR Scanner  Located in the Elliman building L t d i th Elli b ildi • 7T ClinScan high field animal Bruker scanner LOGO

MR Research Facility  The Vaitkevicius MR Center  Emphasis on Education E h i Ed ti • Attracts MR visionaries and scientists • Provides an excellent research learning • Provides an excellent research learning environment for the MR experimentation • Provides guidance to graduate students, research g g , oriented residents as well as young faculty. • Supports dozens of projects across campus LOGO

MR Research Facility  The Vaitkevicius MR Center  Emphasis on Education and Research E h i Ed ti d R h • The MRRF offers strong training for: – Students – Students – Post Docs – Clinical Fellows – Visiting Scholars – Young Faculty • Clinical and translational research Clinical and translational research 8 LOGO

MR Research Facility  The Vaitkevicius MR Center  Emphasis on Research E h i R h • Develop and apply revolutionary MR methods • Apply these methods to detect and monitor • Apply these methods to detect and monitor disease and its treatment • Promote their usage across WSU scientific g community and internationally LOGO

MR Research Facility  The Vaitkevicius MR Center  Emphasis on Research E h i R h • Ongoing clinical research include but not limited to: – Aging – Aging – Breast cancer – Cardiac Imaging – Diabetic retinopathy – Multiple sclerosis – Stroke – Trauma – Tumors 10 LOGO

MR Research Facility  The Vaitkevicius MR Center  Emphasis on Research E h i R h • In the last 10 years, WSU faculty received more than $30M in funding related to imaging than $30M in funding related to imaging MRRF Budget History and Future Consolidated Budget MRRF Budget History and Future Consolidated Budget 10 ions of dollars 9 8 Direct Cost 7 6 5 5 Indirect Cost Indirect Cost Amount in milli 4 3 2 Total 1 0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 year 11 LOGO

MR Research Facility  The Vaitkevicius Magnetic Resonance Center Center  Emphasis on Research • In the last 10 years, MRRF research faculty I th l t 10 MRRF h f lt brought more than $5M in imaging funding MRRF Faculty Grant Support 1,000 900 800 700 housands 600 500 amount in th 400 300 200 100 0 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 year 12 LOGO

PTBIR  Program for Traumatic Brain Injury Research (PTBIR) Research (PTBIR)  Dedicated to campus wide research • School of Medicine S h l f M di i • College of Engineering • Detroit Medical Center • Detroit Medical Center 13 LOGO

PTBIR  Program for Traumatic Brain Injury Research (PTBIR) Research (PTBIR)  Dedicated to campus wide research • Basic research B i h • Neuroimaging • Clinical initiatives • Clinical initiatives 14 LOGO

PTBIR  Program for Traumatic Brain Injury Research Research  Overall goal: • Provide unique training environment to prospective P id i t i i i t t ti neuroscientists • Diagnose and predict the outcome of TBI Diagnose and predict the outcome of TBI – To develop effective treatment approaches to TBI 15 LOGO

PTBIR  Program for Traumatic Brain Injury Research Research  Current activities: • Seminar Series S i S i – Held twice a month to host internal and external speakers • Annual workshop – Held every year in November » This year: November 9 th 2012 » This year: November 9 th , 2012 • Summer School 2013 – To be held from June 3 rd till June 21 st . 16 LOGO

PTBIR  Program for Traumatic Brain Injury Research Research  Summer school 2013: • Primary target: graduate students from Michigan P i t t d t t d t f Mi hi and surrounding states, who are currently enrolled in any biomedical related field and with a focus on y TBI, imaging and neurosciences • Secondary target: Medical community in general – Interested in TBI research I t t d i TBI h – Medical students, residents and physicians who are interested in TBI as well as acquiring CME credits (3 d days, every Friday) F id ) 17 LOGO

Collaborations Henry Ford Hospital MR Innovations, Inc. K Karl Kish l Ki h R Randall Benson d ll B Yongming Dai CNS Jay Meythaler Huan Hu Hospital Heritage Hospital Gerard Reidy Anthony Cacace Albert King 2 VA Grant 0 Y Yuchuan Ding, h Di John Cavanaugh Ronald Hayes 1 MR Imaging 2 2 Robert Welch, Brian O’Neil Liying Zhang King Yang, DTI SWIM Jean Peduzzi Robin Hanks Kenneth Casey Penn State Semyon Slobounov Jinsheng Zhang DMC William Duncan Neurovascular Imaging LOGO

Research projects  Neurodegenerative disease:  Multiple sclerosis, Parkinson’s, Epilepsy, M lti l l i P ki ’ E il ADHD and OCD etc  Cardiovascular disease:  C di l di  Cardiac function  Atherosclerosis etc.  Macular degeneration  and many others 19 LOGO

Vascular Dementia  WSU researchers have made major advances using MRI that have the potential to help improve health care and p p p enhance funding in:  Detection of microbleeds 20 LOGO

Stroke: M Measuring oxygen saturation: i t ti Can we monitor the health of tissue post trauma? A 57 year old male patient with left limb weakness was scanned 144 hours after onset of stroke. DWI DWI SWI SWI SWIM SWIM Recall that TBI can be like having multiple strokes strokes. LOGO

Vascular MS  WSU researchers have made major advances using MRI that have the potential to help improve health care and p p p enhance funding in:  establishing anatomical and functional biomarkers in the study of multiple sclerosis of multiple sclerosis. 22 LOGO

Breakthroughs in TBI Breakthroughs in TBI Research: The role of medullary vein damage in mild TBI SWI: mTBI SWI: mTBI SWIM SWIM LOGO

Breakthroughs in TBI R Research: Monitoring oxygen utilization and iron h deposition: Applications to TBI and PD SWI SWI SWIM SWIM LOGO

Breakthroughs in TBI ea t oug s Research: Breast Cancer Detection using MRI The images above illustrates the heterogeneous distribution of choline (Cho), creatine (Cr), and taurine (Tau) across a lesion using high spatial resolution spectroscopy at 3T. (A) Spectrum from a control area without detectable Cho. (B) Shows clearly elevated Cho. (C) A color-coded Cho image overlaid on the corresponding MR breast image, illustrating two “hot” tumor areas highlighted as increased choline in red. This result indicates a potentially active tumor from which the radiologist could draw important diagnostic conclusions for the future treatment of the patient. LOGO

Fetal imaging  WSU researchers have made major advances using MRI that have the potential to help improve health care and p p p enhance funding in:  Perinatal Research 26 LOGO

Fetal imaging – In Animals Animals  WSU researchers have made major advances using MRI that have the potential to help improve health care and p p p enhance funding in:  Perinatal Research – investigating pre-eclampsia condition in Animal Model (mice) Animal Model (mice) T2 SWI Phase T2 and SWI phase images of the axial view of a fetus. Umbilical Cord Placenta and corresponding umbilical cord is clearly Placenta Coronal View of the multiple fetuses Coronal View of the multiple fetuses visualized in SWI-phase Various lobes of the fetal lung visualized in SWI phase. Various lobes of the fetal lung Fetal Lung in mice pregnancy are also seen. 27 LOGO