Geno2pheno[HCV] - Past, Present & Future Developments Bastian - - PowerPoint PPT Presentation

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Geno2pheno[HCV] - Past, Present & Future Developments Bastian - - PowerPoint PPT Presentation

Nov 05, 2022 841 likes •1.01k views

Geno2pheno[HCV] - Past, Present & Future Developments Bastian Beggel Max-Planck-Institute for Informatics D-66123 Saarbrcken, Germany geno2pheno[HCV] geno2pheno[HCV] web-service for the analysis of HCV sequence data

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Bastian Beggel Max-Planck-Institute for Informatics D-66123 Saarbrücken, Germany

Geno2pheno[HCV] - Past, Present & Future Developments

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV]

  • web-service for the analysis of

HCV sequence data

  • (sub)genotype
  • drug resistance
  • rules based analysis
  • requires drug resistance

relevant part of NS3, NS5A, NS5B geno2pheno[HCV]

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV] – Hit Counts

  • g2p[HCV] started in 2011 with two NS3 inhibitors
  • Currently 9 drugs are supported

TCV, BCP SOF DSV, OMV, PTV

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV]

How to find g2p[HCV]? http://www.genafor.org

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Bastian Beggel geno2pheno[HCV]

Geno2pheno[HCV] – Input Page

identifier upload files paste sequence align and predict

  • ptions

How to find g2p[HCV]? How to find g2p[HCV]? http://www.genafor.org

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Bastian Beggel geno2pheno[HCV]

Geno2pheno[HCV] – Result Page

Sequence Information Resistance Summary Mutation- level Analysis How to find g2p[HCV]? http://www.genafor.org

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Bastian Beggel geno2pheno[HCV]

Geno2pheno[hbv] – Output Options PDF CSV

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Bastian Beggel geno2pheno[HCV]

What else?

  • (Sub)genotype specific rule sets
  • Extended genotype reference set (accounting

for 7 genotypes and 87 subgenotypes)

  • Many more small changes to improve usability
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Bastian Beggel geno2pheno[HCV]

What’s next?

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV] – Present Developments

Genome WT virus Cell culture

  • Rep. cycle

Phenotypic Assay

Fold changes

Therapy Outcome Data

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV] – Future Developments

Sanger Sequencing Next Gen. Sequencing

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV] – Future Developments

Individual Drug Resistance Score Drug Combinations

Boceprevir resistant Paritaprevir resistant Simeprevir susceptible Telaprevir resistant Daclatasvir resistant Ledipasvir resistant Ombitasvir susceptible Dasabuvir susceptible Sofosbuvir susceptible

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Bastian Beggel geno2pheno[HCV]

Acknowledgements

  • Rolf Kaiser
  • Elena Knops,
  • Saleta Sierra Aragon
  • Anna Sikorski
  • Thomas Lengauer
  • Joachim Büch
  • Alex Thielen
  • Mathias Döring
  • Sandra Ciesek (Hannover Medical School)
  • Thomas von Hahn (Hannover Medical School)
  • Daniel Rupp (University Hospital Heidelberg)
  • Ralf Bartenschlager (University Hospital

Heidelberg)

  • Hanaa Gaber (Technische Universität; München)
  • Ulrike Protzer (Technische Universität; München)
  • Christoph Sarrazin (Universtiy Hospital Frankfurt)
  • Jörg Timm,
  • Andreas Walker
  • Verena Keitel
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Bastian Beggel geno2pheno[HCV]

Thank You!

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Bastian Beggel geno2pheno[HCV]

geno2pheno[HCV]

Genotyping Result:

How to find g2p[HCV]? http://www.genafor.org