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Fundamental brain theory: the MAIN challenge to theoretical physics and mathematics of the brain Konstantin Anokhin Institute for Advanced Brain Studies Lomonosov Moscow State University Theoretical physics and mathematics of the brain: 4-5
the MAIN challenge to theoretical physics and mathematics of the brain Konstantin Anokhin
Institute for Advanced Brain Studies Lomonosov Moscow State University
“Theoretical physics and mathematics of the brain: Bridges across disciplines and applications”
4-5 December 2019, Moscow
“When we say that we understand a group of natural phenomena, we mean that we have found a constructive theory that embraces them.“
"The following requirement for a complete theory seems to be a necessary one: every element of physical reality must have a counterpart in the physical theory"
mechanical description of physical reality be considered complete? Physical Review 47 (1935): 777f
“Biologists ask only three questions of a living organism: − How is it built? − How does it work? − And how did it get that way?” Sydney Brenner
evolution
development
development (unique for brain)
Chapter 1. The Physical Basis of Consciousness “A Tentative Answer I would summarize my general hypothesis thus: consciousness is associated with the learning of the living substance.”
"You, your joys and your sorrows, your memories and your ambitions, your sense of personal identity and free will, are in fact no more than the behavior of a vast assembly of nerve cells and their associated molecules. As Lewis Carroll's Alice might have phrased it: "you're nothing but a pack of neurons."
Orchestrated objective reduction (Orch OR) theory
(R.Penrose and S. Hameroff)
Consciousness is based on non-computable quantum processing performed by qubits formed collectively on cellular microtubules, a process significantly amplified in the neurons.
Integrated information theory
(G.Tononi)
“IIT postulates that conscious experience is a fundamental aspect of reality and is identical to a particular type of information—integrated
constructive, predictive and mathematically precise form of panpsychism for the 21st
resolution of the ancient mind-body problem.”
cortex (2-3) cortex (4-6)
from Lichtman et al.
c-Fos whole-mount immunohistochemistry
Sporns et al., (2005), ”The Human Connectome, a structural description of the human brain”
Bullmore E. and Sporns O., Nature Reviews, Vol.10, 2009
“In any field find the most unusual fact and then explore it” J.A. Wheeler
From Quiroga et al., 2009
Implantation sites in the patient brain
Kreiman et al., Proc Natl Acad Sci U S A. 2002. 99(12):8378-83.
Kreiman et al., Proc Natl Acad Sci U S A. 2002. 99(12):8378-83.
From: R.Q. Quiroga (2012) Nat.Rev. Neurosci
Quiroga et al., Nature. 2005. 435 (7045) 1102-7
Husband – Brad Pitt
Quiroga et al., Nature. 2005. 435 (7045) 1102-7
LT LT LT SO SО SО SО SО SО SО Sydney Opera LT Lotus Temple New Delhi
V.B.Shvyrkov, "Systems determination of neuronal activity during behavior" Adv.Physiol.Sci, 14 (1983) 1-27.
Averkin et al., 2002