for Data Science 05/06/2014 MBN Solutions: Business Insight and Big - - PowerPoint PPT Presentation

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The advanced collaborative platform for healthcare and research analytics

Aridhia’s Journey to Software as a Service for Data Science

MBN Solutions: Business Insight and Big Data Maturity in 2014 05/06/2014

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About Aridhia CLINICALLY LED, TECHNOLOGY DRIVEN

Founders: Dr David Sibbald, OBE FRSE Professor Andrew Morris, MB CHB, MSC, MD, FRCP

(EDIN & GLAS), FRSE, FMEDSCI

Multi-disciplinary team: In-house team of 65 clinicians, data scientists and life scientists working with academia, government, public health, pharma and biotech companies. Our goals: To help healthcare providers deliver safe, efficient, effective, equitable, timely and patient-centred care at the lowest cost with the best clinical outcomes. To provide a world class sustainable, secure, collaborative environment where researchers can analyse multiple complex datasets to gain insights into disease trends, treatment efficacy and new therapeutic interventions. To partner with leading academic, government, pharmaceutical and biotechnology organisations on programmes that promote collaboration and drive applications of stratified medicine in clinical practice.

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Past & Present Exemplars in Health Informatics

SERVICE IMPROVEMENT & PATIENT MANAGEMENT ANALYTICS NHS SCOTLAND, NHS TAYSIDE, NHS FIFE, NHS GRAMPIAN DIABETES ANALYTICS DASMAN INSTITUTE & MINISTRY OF HEALTH, KUWAIT CANCER INFORMATICS & RESEARCH DECIPHER HEALTH, NHS TAYSIDE & NHS LOTHIAN CANCER INFORMATICS PETER MACCALLUM CANCER CENTRE, MELBOURNE CANCER ANALYTICS NORTHERN SYDNEY LOCAL HEALTH DISTRICT STRATIFIED MEDICINE SCOTLAND INNOVATION CENTRE – SCOTLAND WIDE MULTI-DISEASE RESEARCH SAFE HAVENS LONDON ACADEMIC HEALTH SCIENCE NETWORKS ANALYTIXAGILITY & DATA SCIENCE LAB PROPOSALS IN H2020

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Our New Business Model

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Moving ahead – a Platform & SaaS

AnalytiXagility is a collaborative analytics platform that enables the discovery of valuable insights through the use of advanced data analysis.

• Collaborate seamlessly in a secure

web-accessible multi-tenant environment

• Delivers new clinical research insight to

improve patient outcomes and resource utilisation

• Drives development & implementation
• f new healthcare innovations

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G-CLOUD

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Data Science – What?

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Data Science – Who?

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Data Science – Evolution of “Awesome Nerds” & “Unicorns”

• Data Science in healthcare needs a

multidisciplinary team involving: analysts, coders, data engineers, clinicians & managers, information governance, strategic thinkers,…

• Grow in-house team and nurture

technical skills & domain understanding

Hilary Mason @ http://www.forbes.com/sites/danwoods/2012/03/08/hilar y-mason-what-is-a-data-scientist/ Drew Conway @ http://www.dataists.com/2010/09/the-data-science- venn-diagram/

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Data Science – Role of Team at Aridhia…

• 1. Product Strategy & Platform Development
• Scope & roadmap definition
• Leadership on analytics, platform, visualisation & user experience
• Development of packaged analytics & service templates
• Cross company collaboration
• 2. Lab Based Professional Services
• A multidisciplinary professional service
• Agile analytics, time boxed / day rate
• Collaborative working with clients on projects
• 3. Community Engagement
• Collateral, blogs, videos, demos & examples, tutorials,...

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Health Knowledge Commons – Vision of the Future?

Nesta

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• Infrastructure for analysis of genomic and clinical data to

develop stratification services & support clinical trials

• Owned and operated by SMS-IC consortium
• Integrated with the NGS Lab
• Multiple roles supported
• Collaborative analytics with clinical and genomic data
• Cluster computing (using Hadoop)
• Scalable storage
• Managed data transfer, access management and audit
• Secure remote access from project team’s desktop
• SMS-IC provides a shared, managed service for multiple

projects

• Partitioned project workspaces
• Software configuration management support
• Production oriented

Stratified Medicine Scotland Innovation Centre (SMS-IC)

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• Targeted deep sequencing of high grade serous ovarian carcinomas in order to

inform future PARP inhibitor studies

• Enabling Stratified Medicine in Early Rheumatoid Arthritis - predicting

methotrexate (MTX) response and toxicity using an integrated polyomic approach

• Identification of Predictive Biomarkers for Gefitinib Response in Oesophageal

Cancer

• A new approach to patient stratification in the development of drugs to treat

chronic inflammatory diseases: linking phenotype to genotype through human tissue organocultures.

SMS-IC Exemplars

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Genomics England (GEL) – Let’s test the model… Map 100,000 whole genomes (or entire DNA) of NHS patients with cancer or a rare disease by 2017

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GEL – 1 of 8 companies to win the SBRI competetion

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Phase 1 funding: March to October 2014 Collaborative approach:

• Aridhia: platform development, testing

annotation services

• Thomson Reuters: license content

and informatics support

• Fios Genomics: bioinformatics
• Glasgow Wolfson Wohl: bioinformatics and

clinical expertise

• SMS-IC: host site

Main themes:

• Industrialising annotation services
• Integrating with the NHS

GEL – SBRI Enabling Technologies

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GEL – AA Competition… should hear in June

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www.aridhia.com govstore.service.gov.uk/cloudstore/search/?q=aridhia andrew.judson@aridhia.com @aridhia, @andyjudson

Thank you for listening…