Foods for Mobility the opportunity Prof Marlena Kruger Massey - - PowerPoint PPT Presentation

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Foods for Mobility the opportunity Prof Marlena Kruger Massey University The health burden Bone hea ne health: I In n NZ There are about 10 10 hip f ip fractures e every day Ab About t one ne thir ird wil ill g go int

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SLIDE 1

Foods for Mobility – the

  • pportunity

Prof Marlena Kruger Massey University

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SLIDE 2

The health burden

Bone hea ne health: I In n NZ

  • There are about 10

10 hip f ip fractures e every day

  • Ab

About t one ne thir ird wil ill g go int nto assis isted l livi ving

  • And

And th the rest t suffer r reduced mobil ility, ind ndependence a and nd pain in

  • The mone

netary cost t is o

  • ver $200

$200million n annu nnually – and t the human man c cost……? ……?

Joi

  • int H

t Health th

  • At

At least 360 360 million n sufferers world wid ide

  • 100 m

100 millio ion n sufferers i in C n China ina; 20 20 million i in I n Ind ndia ia

  • Effects 25

25-50% of

  • f peop
  • ple ov
  • ver 60 ye

years ol

  • ld
  • Highe

ghest rated cause o

  • f wo

work loss in in the U US

  • Estim

imated to shorten n life expe pectancy b by 10 10-15 5 years

  • Projected 20%

20% inc ncrease in nu n number o

  • f sufferers

Mus uscle le

  • Sarcopenia is

is defined d as a decline in in wa walking speed or grip strength a associated wit with low w muscle m mass.

  • Sarcope

penia l leads t to loss o

  • f mobil

ility and nd f func nctio ion, n, f falls, and nd morta tality ty. .

  • Sarcopenia

nia is is pr present in in about 5 5 to 10 10 % o

  • f persons over

65 65 ye years of

  • f age.
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SLIDE 3

What foods do we need?

Minerals, vitamins and protein for bone health Anti-inflammatory action and support of cartilage for joint health Protein to maintain muscle structure and function; foods that maintain fitness/ adaptability for mobility

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SLIDE 4

Value-added product opportunities

  • Novel dairy protein blends and lipids
  • Novel fruit extracts (from novel NZ varieties) – e.g.

berryfruit, grape seed, cherries

  • Kiwifruit (new varieties coming through - large

potential impact), apples, citrus

  • Novel Marine peptides/proteins/lipids
  • Prebiotics (from fruit or other sources such as Manuka

honey) for bone health

  • Glucosamine and collagen in food matrix for joint

health (regulatory issues)

  • Synergies with protein/protein blends + fruit extracts +

lipids etc.

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SLIDE 5

Physical Mobility: Calcium and Vitamin D contribute to the maintenance

  • f normal bones.

Vitamin C contributes to normal collagen formation for the normal function of cartilage. Protein contributes to the maintenance of muscle mass. High Calcium : 2400mg / 100gVitamin D3 - It helps the calcium absorption Strengthening Your Joint with 5 Key Ingredients - High Calcium + Glucosamine + Chondroitin + Collagen + Elastin

Glucosamine, Chondroitin, Hyaluronic acid, MSM

Bone, joint and muscle support

Glucosamine and vit C Soft chews

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SLIDE 6

Kiwifruit – carotenoids, vit K, vit C and fibre

Mice over 8 weeks P-M women

Wolber at al, 2013; Katsumata et al, 2015; Kruger et al, 2016

Pigs over 3 weeks Change in a bone marker over 6 weeks

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Fortified milk and biomarkers for bone and joint health

BONE HEALTH: Added vitamin D, calcium and a prebiotic reduced bone turnover and improved Vitamin D status in 12 weeks

Kruger et al, 2014, 2015

JOINT HEALTH: Changes from baseline

  • f two biomarkers for cartilage synthesis

and degradation

Kruger et al 2015, 2016.

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SLIDE 8

Meng et al. J Bone Miner Res 2009 Nov;24(11):1827-34

Dietary Protein and Muscle Mass

Total Body Appendicular (Arms/Legs)

Lean mass (g) ALM (g)

g/d <66 66-87 >87 g/kd/d 0.84 1.17 1.64 g/d <66 66-87 >87 g/kd/d 0.84 1.17 1.64

Protein intake Protein intake

Effect of baseline protein intake on DXA lean mass 5 years later in community dwelling Australian women (aged 75 years)

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SLIDE 9

The New Zealand Institute for Plant & Food Research Limited

Plant & Food Research and Massey - Human Exercise models for Physical fitness

Repeat quadriceps squats

4 sets of 10 repeats – to failure - 30 mins, 80% max heart rate

Rowing Oxidative Stress Muscle damage Muscle damage

3 sets of 100 repeats Resist arm

Repeat leg extensions High intensity training Fatigue/endurance/training

All out for 60 sec Ramping up repeats x3 /week over 4 weeks

  • R.D. Hurst, et al., (2009) Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro, Mol. Nutr. Food Res. 53, 1-11.
  • M.A. Skinner, et al., (2007) Health benefits of ZESPRI GOLD Kiwifruit: effects on muscle performance, muscle fatigue and immune responses. Proc. Nutr Soc of

NZ, vol 31, 49-59.

  • B. Schrage, et al., (2010) Evaluating the health benefits of fruits for physical fitness: A research platform. J. Berry Res. 1, 35-45.
  • K.A. Lyall, et al., (2009) Short-term blackcurrant extract consumption modulates exercise-induced oxidative stress and lipopolysaccharide-stimulated inflammatory

responses, Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R70-81.

  • S.M. Hurst & R.D. Hurst (Sept 2013) Anthocyanins, innate immunity and exercise. In: Anthocyanins in Health & Disease. Taylor C. Wallace (Ed), CRC Press.
  • Y. McLeay, et al., (2012) Effect of New Zealand blueberry consumption on recovery from eccentric exercise-induced muscle damage. J. Int. Soc. Sports Nutri.
  • D.C. Nieman, et al., (2015) Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA
  • expression. Front Nutr. Sep 9;2:27. doi: 10.3389/fnut.2015.00027.
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SLIDE 10

The New Zealand Institute for Plant & Food Research Limited

Berries prevent muscle damage, speed recovery

50 100 150 200 250 300 Pre Post 2 3 4 5 5 10 15 20 25 30 Pre Post 2 3 4 5 Post exercise (days) Post exercise (days) Units/L (minus pre-exercise values) mg/mL (minus pre-exercise values)

Creatine kinase Myoglobin

* * *

  • 25
  • 20
  • 15
  • 10
  • 5

5 10 15 Pre 12 36 60

% change from initial evaluation

Time (hrs)

*

Peak force production

Speedier recovery, exercise harder, maintain fitness and mobility

  • S. Hurst & R. Hurst (2013) In: Anthocyanins in Health & Disease.

Taylor C. Wallace (Ed), CRC Press.

  • Y. McLeay, et al., (2012). J. Int. Soc. Sports Nutri. doi: 10.1186/1550-2783-9-19
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SLIDE 11

MUSSELING-UP: HIGH-VALUE GREENSHELL™ MUSSEL FOODS

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Re-valuing the Mussel with HVN

  • The aim is to increase the value of

Greenshell Mussel™ (GSM) based food export products.

  • This will be achieved by determining

the effect of these GSM products (and bioactives within) on improving joint and bone health while reducing inflammation

  • Cawthron Institute and Sanford

Limited business led research

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Science plan -1

  • Objective 1: To characterise

known and novel active components of GSM using new high-throughput analytical capability.

  • Objective 2: To demonstrate

the efficacy of GSM foods/ingredients using in vivo and in vitro models of inflammation, joint and bone health.

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Science plan -2

  • Objective 3: To develop targeted

consumer-focused functional formulated foods containing GSM ingredients and to develop an anti-inflammatory activity index to assess the efficacy of GSM food products.

  • Objective 4: To determine the

comparative nutrikinetics including the bioavailability of

  • rally administered specific

active ingredients from whole mussels, mussel extracts and novel functional foods in humans.

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SLIDE 15