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EXTRACTION, ENCAPSULATION AND CONTROLLED RELEASE OF NATURAL COMPOUNDS INS J. SEABRA PhD September 2020 Biography Academic degrees (University of Coimbra, Portugal) BS degree in Chemical Engineering MS in Biomedical Engineering

  1. EXTRACTION, ENCAPSULATION AND CONTROLLED RELEASE OF NATURAL COMPOUNDS INÊS J. SEABRA PhD September 2020

  2. Biography Academic degrees (University of Coimbra, Portugal) • BS degree in Chemical Engineering • MS in Biomedical Engineering • PhD in Chemical Engineering Key publications: • I.J. Seabra , M.E.M. Braga, M.T.P. Batista, H.C. Sousa, Effect of solvent (CO 2 /EtOH/H 2 O) on the fractionated enhanced solvent extraction of anthocyanins from elderberry pomace, Journal of Supercritical Fluids, 2010, 54, 145-152. • A.M.A. Dias, M.E.M. Braga, I.J. Seabra , P. Ferreira, M.H Gil, H.C. de Sousa, Development of natural-based wound dressings impregnated with bioactive compounds and using supercritical carbon dioxide, International Journal of Pharmaceuticals, 408, 9-19, 2011. • Marisa C. Gaspar, H.C. de Sousa I.J. Seabra , M.E.M. Braga, Environmentally-safe scCO 2 P. pinaster branches extracts: composition and properties, Journal of CO 2 Utilization, 37, 74-84, 2020. Keywords: Agrifood by-products, Bioactive compounds, Encapsulation, Extraction, Green technologies, Natural sources, Supercritical fluid

  3. Extraction, encapsulation and controlled release of natural compounds What is the technology being studied? Pressure Supercritical fluid • Supercritical Fluid and Pressurized Liquid Extraction Heater Extraction cell • Supercritical Fluid Impregnation Depressurization Critical point ● valve • Pump Encapsulation and Controlled Release • Flash Nanoprecipitation Gaseous CO 2 Separation vessel Cooler ● Extract Triple point Why is this topic significant? Temperature • High pressure extraction : - Offers a propitious method for drug discovery from natural sources. - Eco-friendly technology, short processing times, extracts with little or no organic co-solvent. • Encapsulation : preserves functional properties and controls the release at desired time and specific target. • Agrifood by-products use: in consonance with bioeconomy and circular economy approaches.

  4. Extraction, encapsulation and controlled release of natural compounds Pheromones How is the topic studied? • High pressure extraction : NPs - Different plant matrices. - Experimental conditions: pressure, temperature, type of solvent. Biopolymer - Chemical analysis of extracts: GC, HPLC, GC-MS, LC-MS, spectrophotometry. monoliths • Encapsulation (Flash Nanoprecipitation) : - Different bioactive compounds. - Experimental conditions: solvents, concentrations. What are the future directions of this research? • Develop scalable extraction techniques coupled to other processes such as drying. • Explore Flash Nanoprecipitation to encapsulate natural extracts.

  5. Contact Inês J. Seabra ijs218@lehigh.edu 610-758-5729

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