ETHOX CHEMICALS CPDA Adjuvants & Inerts Conference 30 April 2019 Post Patent Agrochemical Formulation Overview and Trends 1
DISCLAIMERS & ACKNOWLEDGEMENTS - This is a broad subject with a considerable amount of information as common knowledge - The following presentation is of my own opinion and I do not claim otherwise - All data are cited or referenced accordingly - I would like to acknowledge the follow individual: - Brad Swillen 2
PRIMARY OBJECTIVES – BROAD OVERVIEW Provide an Overview of the Agrochemical market I. and of the Post Patent Agrochemical Market Discuss Current and Potential Future Trends & II. Challenges in Agrochemical Formulations - Pesticide Formulations - Adjuvant Formulations 3
PIEDMONT CHEMICAL INDUSTRIES Corporate Overview
ETHOX CHEMICALS • Location: Greenville, SC • Markets Served: agriculture, oil/gas, paints/inks, coatings, metalworking, personal care, household & industrial cleaning, paper processing, textiles, construction, specialty surfactants. • Complete R&D Center and Advanced Pilot Plant • Research Track Sprayer equipped with Sympatec HELOS laser • Core Synthesis Capabilities: • Alkoxylation, Esterification, and Phosphation • Advanced R&D ready to partner and innovate. 5
GLOBAL CROP PROTECTION MARKET – (US $BILLIONS) 1 Year Crop Protection Non-Crop Total Agrochemical 56.151 6.237 62.388 2015 2016 55.089 6.458 61.547 2017 55.330 6.568 61.898 1 – agropages.com 6
CURRENT LEADING CROP PROTECTION COMPANIES 1 (US $BILLIONS) 2016 2018 – Post-mergers; approximation 1. Bayer Crop Science 12.324 1. Syngenta 9.571 2. Syngenta/ChemChina 9.571 2. Bayer Crop Science 8.810 3. Corteva 7.515 3. BASF 6.163 4. BASF 6.163 4. DowAgroSciences 4.631 5. FMC 5.159 5. Monsanto 3.514 6. UPL 3.966 6. DuPont 2.884 7. Adama 2.877 7. Adama 2.877 8. Sumitomo 2.373 8. Sumitomo 2.373 9. Nufarm 1.969 9. FMC 2.150 10. Beijing Nutrichem 0.685 10. Nufarm 1.969 1 – Agribusinessintelligence.com 7
CURRENT LEADING CROP PROTECTION POST PATENT COMPANIES 1 - (US $BILLIONS) UPL - 3.966 1. Adama - 2.877 2. Nufarm - 1.969 3. Beijing Nutrichem - 0.685 4. Shandong Weifang Rainbow - 0.565 5. 1 – Agribusinessintelligence.com • 8
POST-PATENT MARKET SHARE 1 Generic Market Share - % 70 60 50 40 30 20 10 0 1998 2000 2002 2004 2006 2008 2010 2012 Generic Proprietary Off-Patent Patented 1 - Agrolook 9
BRIEF HISTORY OF POST PATENTS • Evolution of Post-Patent Markets; Approximate Introduction to Market: • Row Crop AG – 1970’s – 1980’s • T&O – Late 1990’s • PCO – Late 1990’s • IVM – Late 1990’s – early 2000’s • ST – Mid- 2000’s 10
POST PATENT MARKET DYNAMICS • Post- patent access to TGAI’s (active ingredients): • Post-Patent Companies registrations begin in the 1970’s • Traditional Distribution accessing active ingredients and obtaining registrations • Chinese and Indian companies have been and will continue to obtain active ingredients registrations. Additionally, MUP’s and EP’s 11
POST PATENT MARKET DYNAMICS • Global Dynamics: • Traditional sources of post patent active ingredients have been in Asia • Supply quality • Supply reliability • Will impact of US Tariffs and changing environmental regulatory schemes push synthesis back to the US? 12
CURRENT OVERVIEW & TRENDS • Current and future trends and associated challenges: • Resistance • Access to multiple TGAI’s; Implication for post -patent manufacturers • New Synthetic Auxin Traits • Biologicals / Biostimulants • Adjuvants – New Technology & “in can” applications • Precision Agriculture • Regulatory Pressure • Organic Markets • H 2 O 13
RESISTANCE • Herbicide Resistant Weeds by MOA Worldwide 1 : • 23 Herbicide Groups • Dominated by ALS Inhibitors, Photosystem II Inhibitors, ACCase Inhibitors, EPSP Synthase Inhibitors • Trends: • R&D pipelines shrinking • Innovation in formulations • Adjuvants • Chemistry rotation • Pre-Emergent Chemistries 1 – www.weedscience.org/Summary/SOASummary 14
ACCESS TO MULTIPLE A.I.’S • Single largest trend and challenge: • As the number of active ingredients become post-patent, generic companies expand access to multiple active ingredients with diverse modes of action. • Formulate with actives in new and multiple classes • Pre and post-emergence maize and soybean herbicides • Seed Treatment Market • How to formulate three, four, five or more different active ingredients into the same formulation? 15
ACCESS TO MULTIPLE A.I.’S • TRENDS : • Suspension Concentrates & Suspoemulsion’s : • Compatibility • Multiple actives with varying degrees of water solubility and hydrophobicity • ID suitable wetting agents and dispersing agents dependent upon each active ingredient • Minimize active ingredient crystal growth • Correct viscosity modifier (s) • Suspensibility and long term storage stability 16
ACCESS TO MULTIPLE A.I.’S • TRENDS : • Seed Treatment Suspension Concentrates • ST formulations are unique and different from crop SC’s. • Seed Treatment Suspension Concentrates for Seed Treatment Custom Blends: • Single and Multiple active formulations blended together in Custom Blends: • Formulate individual products to be compatible in multi- component custom blends • Stabilize and maintain dispersion of actives 17
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ACCESS TO MULTIPLE A.I.’S • TRENDS : • EC’s: • Multiple actives with varying degrees of solvent solubility • Solvent identification / co-solvents • Suitable emulsifiers • Stable with a.i .’s • Good emulsion performance • Tank mix compatibility with other products • Glyphosate • Liquid Fertilizers 19
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NEW SYNTHETIC AUXIN TRAITS • Bayer, BASF and Corteva Application Guidelines: • http://www.xtendimaxapplicationrequirements.com/Pages /default.aspx • http://agro.basf.us/campaigns/engenia/tankmixselector/ • https://www.enlist.com/en/approved-tank-mixes/enlist- duo.html • TRENDS: • Post-patent product approval for tank mixes • Enhance current formulations to adhere to label criteria 21
BIOLOGICALS • Growing market opportunity • Including natural compounds, micronutrients, microorganisms or fermentation products • EPA Registered control products • Non-registered Biostimulants • TRENDS: • Enhance synergies between synthetics and biologicals • Formulation innovations 22
ADJUVANTS • TRENDS: • Enhance biological performance without building new formulations. • Further innovation with DRT’s • Class specific adjuvants? • New and improved chemistry above and beyond standard NI’s and COC’s? • Cost effective 23
PRECISION AGRICULTURE • GPS and other technology into farming • Multiple resources for field data mapping available • TRENDS: • Targeted nutrient and pest control products application technologies • Formulations • Adjuvants 24
REGULATORY PRESSURES • Maintain yields with less active ingredients and label restrictions. • Current issues: • Neonicotinoid bans and reductions – Canada & EU • Glyphosate litigation pressures • Off target movement of active ingredients • Application restrictions • TRENDS: • Increase efficacy of formulations • Combine biologicals with synthetics for pest control • Conventional Seeds 25
ORGANIC MARKETS • Emerging market • Pesticides • Adjuvants • TRENDS: • Improve stability and performance of current formulations • Improve existing formulations with actives such as Copper • Incorporate Biologicals • New 40 CFR inert chemistry w/ organic certification • How can CPDA become more involved in working with state regulatory agencies to assist members with new products and issues? 26
H 2 O • Global agriculture accounts 70% of worldwide water use 1 • Worldwide decreased access to irrigation water • Poor water quality – No easy solution • TRENDS: • Water conditioning agents • Soil surfactants • Effluent water quality improvement 1 – World Bank Group 27
TREND SUMMARY • More effective use of inert chemistry within the current on the 40 CFR list • New inert chemistry outside of what is on the 40 CFR • Increase biological performance with lower label rates • New encapsulation or slow release technology • More robust and functional wetting agents and dispersants • New or alternative viscosity modifiers • New or alternative solvents • Crystal inhibitors • Compatibility agents • Film formers, stickers, penetrants • New and improved DRT’s • AMS alternatives 28
Thank you John M. Moyer IV 610-730-4500 jmoyer@ethox.com
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