ETHOX CHEMICALS CPDA Adjuvants & Inerts Conference 30 April - - PowerPoint PPT Presentation

ETHOX CHEMICALS

CPDA Adjuvants & Inerts Conference

30 April 2019

Post Patent Agrochemical Formulation Overview and Trends

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DISCLAIMERS & ACKNOWLEDGEMENTS

• This is a broad subject with a considerable amount
• f information as common knowledge
• The following presentation is of my own opinion and

I do not claim otherwise

• All data are cited or referenced accordingly
• I would like to acknowledge the follow individual:
• Brad Swillen

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PRIMARY OBJECTIVES – BROAD OVERVIEW

I.

Provide an Overview of the Agrochemical market and of the Post Patent Agrochemical Market

II.

Discuss Current and Potential Future Trends & Challenges in Agrochemical Formulations

• Pesticide Formulations
• Adjuvant Formulations

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PIEDMONT CHEMICAL INDUSTRIES

Corporate Overview

ETHOX CHEMICALS

• Location: Greenville, SC
• Markets Served: agriculture, oil/gas, paints/inks, coatings,

metalworking, personal care, household & industrial cleaning, paper processing, textiles, construction, specialty surfactants.

• Complete R&D Center and Advanced Pilot Plant
• Research Track Sprayer equipped with Sympatec HELOS laser
• Core Synthesis Capabilities:
• Alkoxylation, Esterification, and Phosphation
• Advanced R&D ready to partner and innovate.

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GLOBAL CROP PROTECTION MARKET – (US $BILLIONS)1

1 – agropages.com

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Year Crop Protection Non-Crop Total Agrochemical 2015 56.151 6.237 62.388 2016 55.089 6.458 61.547 2017 55.330 6.568 61.898

CURRENT LEADING CROP PROTECTION COMPANIES1 (US $BILLIONS)

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2016 1. Syngenta 9.571 2. Bayer Crop Science 8.810 3. BASF 6.163 4. DowAgroSciences 4.631 5. Monsanto 3.514 6. DuPont 2.884 7. Adama 2.877 8. Sumitomo 2.373 9. FMC 2.150

• 10. Nufarm

1.969

1 – Agribusinessintelligence.com

2018 – Post-mergers; approximation 1. Bayer Crop Science 12.324 2. Syngenta/ChemChina 9.571 3. Corteva 7.515 4. BASF 6.163 5. FMC 5.159 6. UPL 3.966 7. Adama 2.877 8. Sumitomo 2.373 9. Nufarm 1.969

• 10. Beijing Nutrichem

0.685

CURRENT LEADING CROP PROTECTION POST PATENT COMPANIES1 - (US $BILLIONS)

1.

UPL

• 3.966

2.

Adama

• 2.877

3.

Nufarm

• 1.969

4.

Beijing Nutrichem

• 0.685

5.

Shandong Weifang Rainbow

• 0.565
• 1 – Agribusinessintelligence.com

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POST-PATENT MARKET SHARE1

1 - Agrolook

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10 20 30 40 50 60 70 1998 2000 2002 2004 2006 2008 2010 2012

Generic Market Share - %

Generic Proprietary Off-Patent Patented

BRIEF HISTORY OF POST PATENTS

• Evolution of Post-Patent Markets; Approximate

Introduction to Market:

• Row Crop AG – 1970’s – 1980’s
• T&O – Late 1990’s
• PCO – Late 1990’s
• IVM – Late 1990’s – early 2000’s
• ST – Mid-2000’s

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POST PATENT MARKET DYNAMICS

• Post-patent access to TGAI’s (active ingredients):
• Post-Patent Companies registrations begin in the

1970’s

• Traditional Distribution accessing active ingredients

and obtaining registrations

• Chinese and Indian companies have been and will

continue to obtain active ingredients registrations. Additionally, MUP’s and EP’s

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POST PATENT MARKET DYNAMICS

• Global Dynamics:
• Traditional sources of post patent active

ingredients have been in Asia

• Supply quality
• Supply reliability
• Will impact of US Tariffs and changing

environmental regulatory schemes push synthesis back to the US?

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CURRENT OVERVIEW & TRENDS

• Current and future trends and associated challenges:
• Resistance
• Access to multiple TGAI’s; Implication for post-patent

manufacturers

• New Synthetic Auxin Traits
• Biologicals / Biostimulants
• Adjuvants – New Technology & “in can” applications
• Precision Agriculture
• Regulatory Pressure
• Organic Markets
• H2O

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RESISTANCE

• Herbicide Resistant Weeds by MOA Worldwide1:
• 23 Herbicide Groups
• Dominated by ALS Inhibitors, Photosystem II Inhibitors, ACCase Inhibitors, EPSP

Synthase Inhibitors

• Trends:
• R&D pipelines shrinking
• Innovation in formulations
• Adjuvants
• Chemistry rotation
• Pre-Emergent Chemistries

1 – www.weedscience.org/Summary/SOASummary

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ACCESS TO MULTIPLE A.I.’S

• Single largest trend and challenge:
• As the number of active ingredients become post-patent,

generic companies expand access to multiple active ingredients with diverse modes of action.

• Formulate with actives in new and multiple classes
• Pre and post-emergence maize and soybean herbicides
• Seed Treatment Market
• How to formulate three, four, five or more different active

ingredients into the same formulation?

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ACCESS TO MULTIPLE A.I.’S

• TRENDS:
• Suspension Concentrates & Suspoemulsion’s:
• Compatibility
• Multiple actives with varying degrees of water solubility and

hydrophobicity

• ID suitable wetting agents and dispersing agents

dependent upon each active ingredient

• Minimize active ingredient crystal growth
• Correct viscosity modifier (s)
• Suspensibility and long term storage stability

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ACCESS TO MULTIPLE A.I.’S

• TRENDS:
• Seed Treatment Suspension Concentrates
• ST formulations are unique and different from crop SC’s.
• Seed Treatment Suspension Concentrates for Seed

Treatment Custom Blends:

• Single and Multiple active formulations blended together in

Custom Blends:

• Formulate individual products to be compatible in multi-

component custom blends

• Stabilize and maintain dispersion of actives

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ACCESS TO MULTIPLE A.I.’S

• TRENDS:
• EC’s:
• Multiple actives with varying degrees of solvent solubility
• Solvent identification / co-solvents
• Suitable emulsifiers
• Stable with a.i.’s
• Good emulsion performance
• Tank mix compatibility with other products
• Glyphosate
• Liquid Fertilizers

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NEW SYNTHETIC AUXIN TRAITS

• Bayer, BASF and Corteva Application Guidelines:
• http://www.xtendimaxapplicationrequirements.com/Pages

/default.aspx

• http://agro.basf.us/campaigns/engenia/tankmixselector/
• https://www.enlist.com/en/approved-tank-mixes/enlist-

duo.html

• TRENDS:
• Post-patent product approval for tank mixes
• Enhance current formulations to adhere to label criteria

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BIOLOGICALS

• Growing market opportunity
• Including natural compounds, micronutrients,

microorganisms or fermentation products

• EPA Registered control products
• Non-registered Biostimulants
• TRENDS:
• Enhance synergies between synthetics and biologicals
• Formulation innovations

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ADJUVANTS

• TRENDS:
• Enhance biological performance without building new

formulations.

• Further innovation with DRT’s
• Class specific adjuvants?
• New and improved chemistry above and beyond standard

NI’s and COC’s?

• Cost effective

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PRECISION AGRICULTURE

• GPS and other technology

into farming

• Multiple resources for field

data mapping available

• TRENDS:
• Targeted nutrient and pest

control products application technologies

• Formulations
• Adjuvants

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REGULATORY PRESSURES

• Maintain yields with less active ingredients and label

restrictions.

• Current issues:
• Neonicotinoid bans and reductions – Canada & EU
• Glyphosate litigation pressures
• Off target movement of active ingredients
• Application restrictions
• TRENDS:
• Increase efficacy of formulations
• Combine biologicals with synthetics for pest control
• Conventional Seeds

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ORGANIC MARKETS

• Emerging market
• Pesticides
• Adjuvants
• TRENDS:
• Improve stability and performance of current formulations
• Improve existing formulations with actives such as Copper
• Incorporate Biologicals
• New 40 CFR inert chemistry w/ organic certification
• How can CPDA become more involved in working with

state regulatory agencies to assist members with new products and issues?

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H2O

• Global agriculture accounts 70% of

worldwide water use1

• Worldwide decreased access to

irrigation water

• Poor water quality – No easy solution
• TRENDS:
• Water conditioning agents
• Soil surfactants
• Effluent water quality improvement

1 – World Bank Group

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TREND SUMMARY

• More effective use of inert chemistry within the current on the

40 CFR list

• New inert chemistry outside of what is on the 40 CFR
• Increase biological performance with lower label rates
• New encapsulation or slow release technology
• More robust and functional wetting agents and dispersants
• New or alternative viscosity modifiers
• New or alternative solvents
• Crystal inhibitors
• Compatibility agents
• Film formers, stickers, penetrants
• New and improved DRT’s
• AMS alternatives

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Thank you

John M. Moyer IV 610-730-4500 jmoyer@ethox.com